Monday, December 29, 2025

What is Metabolic Syndrome?

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by Dr. C.V Ramana

Metabolic syndrome is a combination of risk factors that increase the likelihood of developing heart disease, diabetes, and stroke. These risk factors include high blood pressure, high blood sugar levels, excess body fat (particularly around the waist), high triglyceride levels and low levels of good cholesterol. Having only one of these risk factors does not mean that you have metabolic syndrome, however, having one will increase the possibly of developing cardiovascular disease. Having three or more will likely result in a diagnosis of metabolic syndrome. The two critical risk factors for diagnosing metabolic syndrome is excess central body fat and insulin resistance.
The American Heart Association reports that approximately 25 percent of the American population has metabolic syndrome. To diagnose metabolic syndrome your primary care provider will perform tests to look for signs of the disorder. These tests may include a baseline blood pressure measurement, waist circumference measurement, a fasting lipid panel, and a fasting glucose level. Complications of metabolic syndrome include hardening of the arteries, peripheral artery disease, cardiovascular disease, diabetes, heart attack, kidney disease and stroke.
If you think you are at risk for metabolic syndrome, see your primary care provider for an examination and screening. Metabolic syndrome is treatable and the poor outcomes related to living with the disorder for many years are avoidable. Your primary care provider can provide support and encouragement for decreasing your overall body fat by making lifestyle changes. He or she can prescribe medications to reduce high blood pressure, high blood sugar and even high cholesterol. Preventing poor outcomes from metabolic syndrome is certainly possible. Establishing a primary care provider and having regular check ups is the first step in taking control of your health and leading a healthier lifestyle.
You are also welcome to call our Vascular Center to schedule a prompt and free consultation. You can contact us at 405-608-8884. We are a specialized center staffed with highly experienced professionals, including a Vascular/Interventional physician, dedicated to treating vascular disease on an outpatient basis using the latest proven technology to combat this epidemic.
Dr. C.V Ramana is a vascular and interventional radiologist with more than 20 years of practice experience. He has expertise in all areas of vascular and interventional radiology. Dr. Ramana has a Ph.D from Yale University and MD from CWRU in Cleveland, Ohio where he subsequently completed his fellowship in Vascular and Interventional Radiology at the Cleveland Clinic.
Visit Naadi Health at 1 NW 64th Street in Oklahoma City or call (405)-608-8884. www.naadihealthcare.com

New Year, New Life: Naadi patient gets ultimate gift

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The staff at Naadi Healthcare Vascular and Interventional Center helped give June Brown a new lease on life.

story and photo by Bobby Anderson, Staff Writer

June Brown (above left) celebrates new lease on life.

It’s a new year and June Brown is celebrating her new lease on life.
“They said there was really nothing they could do. It was just damaged muscle,” Brown said, recalling a July 2006 injury to her left leg that left her living in pain.
Over the next 13 years, that injury gave way to a vicious cycle of pain, redness and swelling followed by antibiotics.
And building oilfield equipment for a living, that meant Brown spent long days on her feet which just made problems worse.
She managed the best she could until she noticed a hole forming in her leg, about the size of a pencil eraser.
Her doctor put her on another round of antibiotics hoping it would curb the growing infection.
“The doctor was real nice but said he had never seen anything like this and wouldn’t touch it,” Brown remembers.
Finally deciding she had had enough, Brown pressed the issue and sought a second opinion.
Pathology samples showed dead tissue in her leg due to no blood flow.
“It was basically just dying,” she said.
She was horrified and in need of help.
GIFT OF HEALING
That’s when she found Dr. C.V. Ramana and Naadi Healthcare Vascular and Interventional Center.
Dr. Ramana was able to restore blood flow for the first time in more than a decade.
“Within two weeks I was released from wound care. You wouldn’t believe the difference,” Brown said. “It’s got a scar but it’s a totally different leg. I’m just so happy there’s no pain, no nothing.
“I can forget about it.”
Naadi specializes in peripheral vascular disease and venous insufficiency.
From pain in the calf while walking to non-healing wounds, Naadi works on getting people back to their former selves.
“Ultimately, the end goal is if somebody has a really bad wound we don’t want them to lose their limb. We want to save their limb, save their life. People who have amputations have a very high mortality rate,” said Shelby Dudley, a radiology technologist at Naadi.
Naadi Vascular and Interventional Center is the first outpatient center in Oklahoma City dedicated to vascular and interventional radiology.
Interventional radiology (also known as IR) is the minimally invasive, image-guided treatment of medical conditions that once required open surgery.
Breakthroughs in technology and imaging have created new treatment choices for patients. In this new era of medicine, there is no longer one “right way” to handle your condition.
Personalized medicine means doing the right thing for each individual patient. More than ever, it’s imperative for you to know and understand all of the available options to treat your condition or disease. In many cases, there is a minimally invasive approach that could dramatically reduce your pain, risk and recovery time.
“A lot of people have pain in their legs and they think it’s normal and it’s not,” Dudley said. “A lot of people have peripheral vascular disease and they don’t know. It’s a misdiagnosed disease. This can be treated and there are things that can be done to prevent it.”
Controlling diabetes and blood pressure, exercise and maintaining a healthy diet are some of the biggest modifiable risk factors that can help prevent peripheral artery disease.
After the injury, Brown resigned herself to her current condition. She didn’t know things could be better.
Not until she visited Naadi and Dr. Ramana.
“He was great. He was real sweet and real concerned,” Brown said of Dr. Ramana. “He was patient with me. He didn’t try to push. He let me go at my own pace. I appreciated that. He made it to where I would understand what was going on to help relieve some of my anxiety.”
“His staff is really sweet. You couldn’t ask for better, more concerned people that want to make sure you’re comfortable, relaxed and healthy.”
Patients are able to self-refer to Naadi. Taking her health into her own hands was the best gift Brown could have given herself.
“That’s something I hope we can make a change in the culture,” Ramana said. “People see all of that as a normal part of growing old and kind of accept that and don’t think there is anything they can do to impact that.”
“One of the nice things about being in a facility like this is you get to see those patients over and over and you get to see how you’ve impacted their lives,” Ramana said. “It’s very rewarding.”
And now Brown has a new lease on life.

Visit Naadi Health at 1 NW 64th Street in Oklahoma City or call (405)-608-8884. www.naadihealthcare.com

Trauma One Re-Verified as Level 1 Trauma Center

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The trauma center at OU Medicine has been re-verified as a Level 1 Trauma Center by the American College of Surgeons.
In 2001, the Trauma One Center, at both OU Medical Center and The Children’s Hospital, was designated as Oklahoma’s only Level 1 Trauma Center, the highest national ranking a trauma center can receive. The verification process by the American College of Surgeons validates that trauma centers have all resources necessary for any type of trauma care.
“Earning verification from the American College of Surgeons is gratifying because it reflects the commitment and hard work that our healthcare professionals deliver day in and day out,” said OU Medical Center President Kris Gose. “The process validates that we have all resources in place to provide optimal trauma care at any time.”
As a Level 1 Trauma Center, Trauma One offers comprehensive care that can handle the most critical emergencies. Trauma One provides 24-hour coverage by general surgeons, and quick availability of care in specialties such as orthopedic surgery, neurosurgery, anesthesiology, emergency medicine, radiology, internal medicine, plastic surgery, oral and maxillofacial surgery and more.
Operating rooms and trauma surgeons are available 365 days a year, and the air ambulance Medi Flight can be dispatched in minutes to airlift patients to Trauma One. A multidisciplinary team of physicians, nurses, specialists and other health care professionals are always on site, using advanced technology to treat the most severe and critical injuries. Level 1 Trauma Centers provide total care for every aspect of injury, from prevention through rehabilitation.
In addition to serving people across Oklahoma, Trauma One, because of its location in the geographic center of the state, is ideally positioned for regional access as well. An injured person’s best chance for survival is when treatment occurs within an hour of the event. Paramedics, ambulance systems and other hospitals across the state play key roles in transporting patients to Trauma One within an hour.
“The Trauma One Center has been able to save countless lives in its nearly 20-year existence,” said Roxie Albrecht, M.D., medical director of Trauma One. “As part of a tertiary care center, it is important that we participate in continuous assessment of our program. Our aim is to always provide the highest level of care to people when they need it the most.”
The verification of Trauma One was conducted by the Verification Review Committee, a subcommittee of the Committee on Trauma of the American College of Surgeons. Verified trauma centers must meet the essential criteria that ensure trauma care capability and institutional performance, as outlined by the American College of Surgeons’ Committee on Trauma in its manual Resources for Optimal Care of the Injured Patient. There are five categories of verification in the program. In addition to submitting documentation, Trauma One had an on-site review by a team of experienced site reviewers.
Level 1 Trauma Centers like OU’s Trauma One also provide public education and prevention information to people across the state. OU’s primary areas of advocacy are: ATV Ride Safe Oklahoma, which provides classes to increase awareness of ATV safety guidelines; Stop the Bleed, a course that teaches how to save someone’s life by controlling bleeding; and concussion education for coaches, game officials, athletes and parents about the nature of concussion and head injury.

Local Business Wins National Awards

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Laura Lynn’s Home Care Named as Provider and Employer of Choice

Laura Lynn’s Home Care announced today that it has received both the 2019 Best of Home Care® – Provider of Choice and Employer of Choice Awards from Home Care Pulse. These awards are granted only to the top-ranking home care providers, based on client and caregiver satisfaction scores gathered by Home Care Pulse.
Laura Lynn’s Home Care is now ranked among a small handful of home care providers across the country who have proven their ability to provide an exceptional working experience to employees and the highest quality care to clients.
“We want to congratulate Laura Lynn’s Home Care on receiving both the Best of Home Care – Provider of Choice Award and the Best of Home Care – Employer of Choice Award,” says Erik Madsen, CEO of Home Care Pulse.
“Since these awards are based on real, unfiltered feedback from clients and caregivers, Laura Lynn’s Home Care has proven their dedication to providing a great work environment and solid training to employees, while maintaining their focus on client satisfaction. We are pleased to recognize their dedication to quality professionalism and expertise in home care.”
Best of Home Care providers have contracted with Home Care Pulse to gather feedback from their clients and caregivers via live phone interviews each month. Because Home Care Pulse is an independent company, it is able to collect honest and unbiased feedback.
“These awards confirm what we have always believed. Our team of caregivers is the absolute best you can get. We’re so proud of their hard work, their compassion and the care they provide to the families we serve,” says Laura Hicks, CEO and founder of Laura Lynn’s Home Care.
“Our goal at Home Care Pulse is to empower home care businesses to deliver the best home care possible,” says Erik Madsen, CEO of Home Care Pulse. “We are happy to recognize Laura Lynn’s Home Care as a Best of Home Care award-winning provider and celebrate their accomplishments in building a team of happy, qualified caregivers who provide outstanding care for their clients.”
For more information about Laura Lynn’s Home Care, visit LauraLynnsHomeCare.com or call (405) 418-2961.
Established in 2002 by Laura Lynn Hicks, Laura Lynn’s Home Care is a licensed home care agency and has become Oklahoma’s premier provider of private-duty services. Laura Lynn’s Home Care provides in-home assistance delivered by a team of Certified Home Health Aides. Laura Lynn’s Home Care clients are able to remain in the comfort of their homes, while receiving long-term care or post-operative assistance.

 

IS GRANDMA STARVING? THE ANSWER MAY SURPRISE YOU

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Kevin Morefield and Zella Classen of Valir Pace deliver food and pre-packaged to meals to 74-year-old Sharon Gibson at her Oklahoma City home. Half of all seniors are at risk for malnutrition. Gibson has battled malnutrition and a variety of health issues, but she says she is living life again and enjoying it thanks to Pace.

When you hear the word “malnutrition,” you probably think of people in impoverished countries, but the fact is, one in every two older adults is at risk of becoming malnourished.
An elderly Oklahoma City woman was that one in two. Sharon Gibson said she was wasting away. Doctors had given up hope and so had she.
“It was just all overwhelming and I was to the point where I didn’t care whether I lived or died,” the 74-year-old said.
Malnutrition in older adults is a hidden and growing epidemic and a costly one. The estimated price tag of the increased health care costs for disease-associated malnutrition in older U.S. adults tops $51 Billion a year. Hunger is not the sole cause. Sometimes it’s about eating the wrong foods and sometimes medical conditions like cancer, diabetes and Alzheimer’s are to blame.
Gibson had been diagnosed with Chronic Obstructive Pulmonary Disease, which left her constantly out of breath. She also had digestive issues that impacted her ability to eat, as well as trouble standing, which made it difficult to cook.
“I was very sick physically, emotionally. I couldn’t eat. My digestive system was shot. My lungs were shot – my whole bone structure. I couldn’t even stand up straight,” she explained. That was before Gibson found Valir Pace, a non-profit program that provides all-inclusive care to older adults.
“A lot of participants have come to me when I’m doing their initial assessment and they say, ‘you know, sometimes I have to pay my medicine, you know, pay for medicine and sometimes I have to decide if I want to eat or what I’m going to buy to eat and that’s so heartbreaking,” said Zella Classen, MA, RD/LD, director of Food and Nutrition at Valir Pace.
At Pace, Classen and the entire nutrition team spend their days preparing, serving and packing meals for delivery to participants. They know malnutrition in older adults can lead to a variety of health problems. These include:
• An increased risk of infection due to a weak immune system
• Poor wound healing
• Muscle weakness and decreased bone mass, which increases the risk of falls and fractures
• A higher risk of hospitalization and death
“A lot of times someone will come to me and they may not have been educated on an appropriate diet for them. And remember, as we are get older, we may develop a chronic disease like diabetes or heart disease, and things like that; and they may not have been educated on that. Or if they have been, they really struggle on getting the right foods for that diet because of their limited income. So, we try to work with them on educating and then trying to help solve that problem on getting them the appropriate foods,” Classen said.
Today thanks to Valir Pace, participants have access to two meals a day, as well as delivery of specially prepared meals and groceries to their homes. It’s not just providing food, though. Classen said it is about providing the right food and the right nutritional supplements to optimize health.
Today, Gibson has a very different outlook on life.
“Nutrition is the basis of everything. If you’re not eating, your body isn’t functioning. You can’t do anything else. So, Zella interviewed me and asked really good questions. They got to the root of my digestive problems and set up a plan with me and, slow but sure, I gathered strength,” she said.
Gibson pays nothing for the program – a program she says has literally saved her life.
“They’ve turned my life around. I’m living again. I’m not just existing. I’m not waiting to die. I’m living and enjoying each day,” she said.
To find out if you or a loved one qualifies for the program, visit www.valirpace.org

SAVVY SENIOR: IRS Introduces a Tax Form Created for Older Taxpayers

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Dear Savvy Senior,

A couple months back I read that the IRS will be offering a new senior-friendly tax form this tax season that will be easier to use. What can you tell me about this? Paper Filer

Dear Filer,
It’s true. The Internal Revenue Service (IRS) has created a new federal income-tax form specifically designed for senior taxpayers, age 65 and older, that should make filing a little easier this year, particularly those who don’t file electronically. Here’s what you should know.
Form 1040-SR
Created by the 2018 Bipartisan Budget Act, the new two-page simplified federal income tax form is called the 1040-SR. Similar in style to the old 1040-EZ form that the IRS discontinued last year, the new 1040-SR has larger print and better color contrast that makes it easier to read.
In addition, it also includes a chart to help older taxpayers calculate their standard deduction, which may help ensure that fewer seniors neglect to take the additional standard deduction that they are entitled to. For 2019, the additional deduction for those 65 or older or the blind is $1,300.
The 1040-SR form also has specific lines for retirement income streams such as Social Security benefits, IRA distributions, pensions and annuities, along with earned income from work wages and tips. And, it allows a child tax credit for seniors who are still taking care of a dependent child or grandchild.
You can also report capital gains and losses, as well as interest and dividends on this new form. Any of the tax schedules available to those using the standard form 1040 may also be used with the 1040-SR.
You should also know that the 1040-SR doesn’t put a limit on interest, dividends, or capital gains, nor does it cap overall income like the old 1040-EZ form did. But, if you have to itemize because of state and local taxes or charitable giving, then you will not be able to use the new Form 1040-SR.
Paper Filing Advantage
Seniors who use tax-preparation software to file their taxes will be able to generate a 1040-SR, but the new form will provide the most significant benefit to taxpayers who still fill out and file their returns on paper.
Last year, about 88 percent of the 153 million individual federal tax returns filed to the IRS were filed electronically. About 5 percent were prepared using tax software, then printed out and mailed to the agency, while about 7 percent were prepared on paper.
To use the new 1040-SR tax form for the 2019 filing year, taxpayers, including both spouses if filing jointly, must be at least age 65 before Jan. 1, 2020. You also don’t have to be retired to use the form – older workers can use it too. But early retirees (younger than 65) cannot use 1040-SR.
To see the 2019 draft version of the new 1040-SR form, go to IRS.gov/pub/irs-dft/f1040s–dft.pdf.
Tax Preparation Help
If you need help filing your tax returns this year, consider contacting the Tax Counseling for the Elderly (or TCE) program. Sponsored by the IRS, TEC provides free tax preparation and counseling to middle and low-income taxpayers, age 60 and older. Call 800-906-9887 or visit IRS.treasury.gov/freetaxprep to locate a service near you.
Also check with AARP, a participant in the TCE program that provides free tax preparation at more than 4,800 sites nationwide. To locate an AARP Tax-Aide site call 888-227-7669 or visit AARP.org/findtaxhelp. You don’t have to be an AARP member to use this service.

Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of “The Savvy Senior” book.

MAKE EXERCISE A HABIT FOR BEST HEALTH OUTCOMES

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Joanne Skaggs, M.D., OU Medicine internal medicine physician.

By Joshua Vascil, OU Medicine

When it comes to healthy and effective exercise habits, the amount of time and effort you can put in to the workouts is the key. However, an OU Medicine internal medicine provider says there are some helpful options for those who don’t have much time to work out.
According to the Journal of the American Medical Association, adults should spend 150 to 300 minutes per week of moderate-intensity, or 75 to 150 minutes a week of vigorous-intensity aerobic physical activity. The Journal also recommends adults perform muscle-strengthening activities that involve all major muscle groups two or more days a week.
Joanne Skaggs, M.D., OU Medicine internal medicine physician, says time does matter when it comes to your workout habits, however, if you don’t have much time, she recommends High Intensity Interval Training or HIIT work-outs or simply limiting idle time throughout the day.
“Weight-bearing exercise is key for metabolism and losing weight just as much as aerobic physical activity is,” Skaggs said. “You always want to do a combination.”
Maintaining a routine to ensure that you get the most out of your exercise habits is important, Skaggs said. She recommends marking time for exercise on a calendar. “It forces it to become part of your schedule so that it’s harder to ignore, or at least there is some guilt. Group fitness is also a good way to motivate and become socially engaged in your community.”
For those who can’t find time or can’t make it to a fitness facility or gym regularly, Skaggs suggests trying to limit idle time by incorporating some of these activities in your day:
· Move more
· Sit less
· Park at the back of the parking lot
· Take the stairs when you can
· Incorporate physical activity into family time
· Look for fitness videos online, even if it’s only a 10 minute workout
“I always recommend the rule of 3’s,” Skaggs said. “Three minutes for three days in a row. Increase by three minutes every three days until you are able to reach 30 minutes. It’s much more doable this way.”
Skaggs warns that it’s always important everyone knows their limits and not push too hard, to avoid injury. “Do not go out and try and lift excessively or over exert yourself. Know your body. Do what you can, gradually pushing yourself to maintain a steady, healthy exercise pattern. And, you need to realize that physical fitness and health takes time. You’re not going to lose 50 pounds overnight.”
Before starting a new exercise and fitness regimen, it is important to check with your doctor.
OU Medicine has primary care physicians available at many locations across the Oklahoma City metro. For more information, go to: https://www.oumedicine.com/oumedicine/primary-care

Buck and Brightmusic Barnstorm Chamber Music

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Ensemble performs woman composer Libby Larsen with Mozart, Weber, Schoenberg

Guest pianist Stephen Buck joins the Brightmusic Chamber Ensemble in this season’s third concert, “Rustic Gardens,” Tuesday, January 21, 7:30 p.m at St. Paul’s Cathedral. Brightmusic continues the season featuring female composers with “Barn Dances” by Grammy Award winner Libby Larsen, in addition to works by Weber, Mozart, and Schoenberg. Buck serves on the academic faculty of State University of New York (SUNY) Purchase Conservatory of Music and champions new music.
Cowboy dances inspired American Libby Larsen (b. 1950) to write “Barn Dances” for flute, clarinet, and piano. Larsen named each movement for a dance step “to take a flight of fancy in each movement and to create the musical equivalent of a calendar drawing.” The second movement, Divide the Ring, pays homage to country singer Gene Autry.
“Rustic Gardens” continues with the Quintet for Clarinet and Strings in B-flat major (Op. 34) by German composer Carl Maria von Weber (1786-1826) and the Quartet No. 1 for Flute and Strings in D major (K. 285) by Wolfgang Amadeus Mozart (1756-1791). Weber had his friend, clarinet virtuoso Heinrich Baermann, in mind, with rich technical and melodic passages for the soloist. Mozart likewise wrote his quartet for Dutch surgeon and flutist Ferdinand Dejean. The quartet charms with clear form and texture.
In contrast is the harmonically complex Chamber Symphony No. 1 by Austrian Arnold Schoenberg (1874-1951). The piece marks the end of his conventional (post-Romantic) period and anticipates his evolution to a twelve-tone technique, giving equal emphasis to all notes.
Musicians appearing in this concert are: Stephen Buck (piano), Gregory Lee and Katrin Stamatis (violin), Mark Neumann (viola), Jonathan Ruck (cello), Parthena Owens, (flute), and Chad Burrow (clarinet).
Admission is $20 at the door and free for children, active-duty military, and students with ID.
Brightmusic Chamber Ensemble, Oklahoma City’s own chamber ensemble, presents fine classical chamber music in acoustically-rich St. Paul’s Cathedral at NW 7th and Robinson near downtown Oklahoma City. Free parking is available south of the cathedral. For more information about the ensemble and upcoming concerts, visit www.brightmusic.org

Medical Center Earns OHA Excellence in Quality Awards

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The Oklahoma Hospital Association presented Excellence in Quality awards to four hospitals during its recent annual convention on Nov. 14. This award recognizes exceptional efforts to improve hospital quality and patient care and represents the highest level of professional acknowledgement from the OHA Council on Quality & Patient Safety.
Twenty-three OHA member hospital award application submissions were scored based on their story of identification of a project specific to identified needs within the hospital, creating innovative interventions that incorporate evidence-based best practices, demonstrating measurable and quantifiable results, sustaining/spreading the success within the hospital, and stimulating learning for others.
One award was presented in each of four categories based on hospital size: critical access hospital, 26-100 beds, 101-300 beds, and greater than 300 beds.
INTEGRIS Southwest Medical Center earned the 2019 Excellence in Quality award for a hospital with more than 300 beds.
INTEGRIS Southwest Medical Center, Oklahoma City
Project Title: Blood Culture Collection Performance Improvement Project
Submitted by: Tami Inman, BSN, RN, CIC, infection preventionist
The goals of the awards are to recognize outcomes in quality performance practices, capabilities and results; share best practices, challenges and successes among Oklahoma hospitals; and stimulate innovation, knowledge and learning in achieving quality and safety in health care among member hospitals.

New use for OMRF brain cancer treatment could extend lives

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Dr. James Battiste (left) is leading the clinical trial for OKN-007, an experimental drug that Dr. Rheal Towner (right) helped pioneer to treat brain cancer patients. (Photo courtesy of the Oklahoma Medical Research Foundation)

An experimental brain cancer compound developed at the Oklahoma Medical Research Foundation is being used in a new study that could considerably extend the lives of glioblastoma patients.
In a study at the University of Oklahoma’s Stephenson Cancer Center, the OMRF compound OKN-007 is being combined with Temodar, the current standard-of-care medication for glioblastoma. Researchers hope to learn if it can enhance Temodar’s effectiveness for a longer period of time.
Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis. Only 1 in 20 glioblastoma patients will live five years.
Temodar has been proven to work, but in most cases, patients tend to become resistant to the drug after approximately three months.
In combination, OKN-007 allows Temodar to remain effective for longer with less resistance, thus extending treatment well beyond the three-month window, perhaps indefinitely, said OMRF Vice President of Technology Ventures Manu Nair.
“Several additional months of treatment with Temodar can dramatically prolong the lives of patients and keep them from enduring other grueling treatments that can compromise their immune systems,” said Nair.
OKN-007 had been in trials to determine safety and efficacy since 2013. The compound was developed by OMRF scientists Rheal Towner, Ph.D., and Robert Floyd, Ph.D., as a novel therapeutic that dramatically decreased cell proliferation (spread) and angiogenesis (formation of new blood vessels), and it turned on the process of removing damaged cells so they can’t become cancerous.
“OKN-007 has been promising, but until now, it was only used in very late-stage cancer where patients are out of other options,” said Nair. “By combining it with Temodar, it offers a longer, more effective treatment regimen.”
The new study is led by James Battiste, M.D., Ph.D., medical director of the Comprehensive Brain Tumor Program at the Stephenson Cancer Center.
An estimated 12,000 Americans are diagnosed with glioblastoma each year, according to the American Brain Tumor Foundation. The standard treatment regimen involves surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy. Still, the tumor almost always grows back.
“By combining Temodar and OKN-007 following initial surgery to have the brain tumor removed, we see potential for these patients to added benefit from an existing drug already proven to work, but for a much longer period of time,” said Nair.

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