Thursday, November 27, 2025

Hospital recognized for reducing tobacco use among patients

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Hospitals Helping Patients Quit (HHPQ), an Oklahoma Hospital Association (OHA) initiative, recognized 11 hospitals and clinic partners at OHA’s recent Connect 22 annual conference that have achieved notable benchmarks in reducing tobacco use in Oklahoma. These visionary hospitals and clinics have implemented a permanent and standard best-practice protocol for identifying, counseling, and referring individuals to the Oklahoma Tobacco Helpline (OTH) for coaching support and nicotine replacement therapy.
OHA recognized these hospital leaders for achieving notable benchmarks in clinical tobacco treatment:

Helpline Referrals 100-499
Great Plains Regional Medical Center, Elk City – 100 referrals

McAlester Regional Health Center – 150 referrals
Cedar Ridge Behavioral Hospital, Oklahoma City– 275 referrals

Helpline Referrals 500-999

AllianceHealth Ponca City – 500 referrals

Stillwater Medical Center – 600 referrals
INTEGRIS Health Edmond – 600 referrals

Helpline Referrals 1000-1999
OU Health, Oklahoma City – 1,000 referrals

Comanche County Memorial Hospital, Lawton – 1,100 referrals

Helpline Referrals 2000 or more

SSM Health St. Anthony Hospital – Oklahoma City – 2,850 referrals

Chickasaw Nation Medical Center, Ada – 5,000 referrals

INTEGRIS Outpatient Clinics – 8,600 referrals
Through effective, health care provider-driven tobacco treatment services, HHPQ partner hospitals and clinics have referred 55,000 patients to the OTH, resulting in an estimated 39,000 years of life saved and $19.5 million dollars in reduced health care costs as well as personal spending on tobacco products.
The Tobacco Settlement Endowment Trust (TSET) supports OHA’s Hospitals Helping Patients Quit and the Oklahoma Tobacco Helpline. For more information the HHPQ initiative, go to https://www.okoha.com/hhpq. For information on the Oklahoma Tobacco Helpline,
http://okhelpline.com.

Inaugural Senior Marathon Includes Walking

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Kirk Wettengel, 63, from Norman, was included in KFOR’s Kevin Ogle, and Linda Cavanaugh’s live television coverage of the Sunday marathon beginning at 6 a.m. each year.

Story by Darl DeVault, contributing editor

Susan Vaughan, 62, was part of a team competing in the Oklahoma City National Memorial & Museum’s largest fundraiser to support its year-round operation.

Seniors 65 or older who like to walk or run can invest in a new experience, the Senior Marathon, on April 29th at the 23rd annual Oklahoma City Memorial Marathon, akin to taking a vacation rather than buying themselves a new toy. Psychologists say it is much better for one’s well-being to invest in experiences rather than purchasing new things to own.
After 22 years of community service to help fund the Oklahoma City National Memorial & Museum, the Oklahoma City Memorial Marathon now provides a new experience.
For the first time, seniors who walk or run before the event can support the downtown museum to help to honor the victims, survivors, rescuers, and those affected by the April 19, 1995 bombing. Mercy is the presenting sponsor of the inaugural event.
Beginning in January, Senior Marathoners who sign up will walk or run 25 miles before race weekend. They can walk as they typically walk or run in their local areas, recording their 1.5 miles weekly. They add up their mileage on a Senior Marathon Running Log available online 2023-Senior-Marathon-Running-Log.pdf (okcmarathon.com) to equal the first 25 miles of a marathon.

Kirk Wettengel, 63, from Norman, was included in KFOR’s Kevin Ogle, and Linda Cavanaugh’s live television coverage of the Sunday marathon beginning at 6 a.m. each year.

This mileage allows them to be a part of one of our nation’s most significant feel-good events for fitness in the lead-up to the “Run to Remember” event Sunday, April 30. The day before the marathon, Saturday, at 8.m., the Senior Marathoners complete their event between the 7 a.m. start to the 5K run and the Kid’s Marathon of a similar style at 9 a.m.
From the marathon starting line at the Oklahoma City National Memorial, seniors can run or walk the last 1.2 miles of their marathon distance directly south to the finish in Scissortail Park to be part of something much bigger than themselves. This allows seniors to feel like “elite” participants because of the on-course support from a massive outpouring of cheering from volunteering OKC residents.
These new Senior Marathoners can feel the camaraderie of attending, interacting, and supporting the Health and Fitness Expo that Saturday at the Oklahoma City Convention Center. The OKC Convention and Visitors Bureau and OU Health present the Expo adjacent to the finish line.
“There’s a generation of Oklahomans who were ever-present on April 19, 1995 … so we want to reconnect both the Memorial and race weekend with the generation that was so key on that day,” said Chris Fleming, Marathon trustee chairman. “The Memorial Marathon is America’s most meaningful marathon, and the new Senior Marathon will now be a part of it.”
Oklahoma City provides walking opportunities on its trail system, but walkers in groups along these trails are a rarity. This specific new goal in April reached with the logging of miles in January, February, and March has the potential to spark groups of seniors socializing as they use the trail system. Officials say the YMCA, senior centers and community agencies will offer senior walking events for those wanting to accumulate 25 miles in a group.
The two-day event some years hosts more than 25,000 runners and walkers from every state and several foreign countries. Aside from this inaugural inclusion of seniors, the event offers a marathon, half marathon, marathon relay (5 member teams), 5K, Kid’s marathon and a wheelchair division.
Costing $30, seniors will receive an event t-shirt, finishing medal and free entry to the Museum with their bib number as they share the experience with their friends and family. Achieving their fitness goal can energize many people to participate in an activity providing good health, a key to aging gracefully.
This is just one of the ways this new facet of the marathon can stimulate Oklahomans and those around the country to enhance their lives at the finish line in Oklahoma City. The marathon weekend is the largest fundraiser for the privately owned and operated Oklahoma City National Memorial & Museum.
The marathon has built a reputation as one of the best in America, praised in many running publications. It also attracts legends of marathoning to speak at the Expo and run at the event. This new form of inclusion has the potential to make the event even more significant as one of the premier marathons in the country. For more info, go online to: *NEW* Senior Marathon – Oklahoma City Memorial Marathon (https://okcmarathon.com/).

VillagesOKC reflects on a year of service to older adults

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VillagesOKC Executive Director addresses attendees at the nonprofit’s Fourth Anniversary Celebration.

By Eddie Roach

As the new year begins, VillagesOKC reflects on a very rewarding 2022 and looks forward to an even bigger and better 2023.
VillagesOKC was established in 2018 as a plan founded on relationships rather than transactions. Like many small towns in Oklahoma, here like-minded members can trust the connections to valuable resources, education and programming. Membership allows for personal responsibility while Empowering Independence for mature adults to age well – in the way they choose.
The combination of internal leadership and external visibility has raised awareness and opportunities for VillagesOKC. Yet its three core values remain unchanged:
* LEARN (growing the brain at any age)
* PLAN (for the bumps in life)
* SERVE (helping others is life-giving)
Highlights of 2022 accomplishments:
LEARN:
* Offered monthly iPhone and iPad technology support
* Participated in monthly Town Hall Lectures
* Held six-week Brain Health Academy
* Continued 12-month Senior Living Truth Series as educational partners
PLAN:
* Updated the Gathering Information for Transitions (GIFT) workbook and expanded the number of facilitators
* Made GIFT registration, scheduling and payment available online
* Videoed GIFT testimonials for informational sharing
* Piloted one-hour workshops for Medical Power of Attorney and Advance Directive
SERVE:
* Launched the Veteran Initiative with pinning of 350 veterans at the Oklahoma History Center
* Expanded Caregiver Ambassadors to 18 faith communities
* Grew an exciting monthly women’s coffee
* Expanded partnership with NewView Oklahoma
* Established partnership with OKC Friday Newspaper, Oklahoma Warriors Honor Flight and Force50 Foundation
In 2023, VillagesOKC will begin LifeSkills Academy, expand The GIFT and Power of Attorney Workshops, expand the Veterans Initiative, double the number of Church and Synagogue connections, and double the VillagesOKC Advisory Board.
VillagesOKC is becoming the magnet, the trusted one source for senior connections in greater Oklahoma City.
To learn more about VillagesOKC, go to their website: https://www.villagesokc.org/ or call (405) 990-6637.

SAVVY SENIOR: A Checklist of What to Do When a Loved One Dies

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Dear Savvy Senior,

What steps need to be taken after a loved one dies? My 71-year-old uncle, who’s divorced with no children, has terminal cancer. He’s asked me to take care of his affairs so I would like to find out what I need to do after he passes away.– Unsure Nephew

Dear Unsure,
I’m very sorry to hear about your uncle. The death of a loved of can bring about a host of different tasks and responsibilities. Here’s a list of some things you can do now, and after his death, that can help keep a sad event from becoming even more difficult.
Before Death Occurs
There are several tasks you can do now while your uncle is still living that will make things easier for you after he dies.
For starters, find out where he keeps all his important papers like his trust and/or will (also make sure it’s updated), birth certificate, Social Security information, life-insurance policies, military discharge papers, financial documents, key or combination to a safe deposit box or a home safe. Also make a list of his digital assets (including usernames and passwords) like his email account, online banking accounts, social media accounts, etc.
If your uncle doesn’t have an advanced directive, help him make one (see CaringInfo.org for free state-specific forms and instructions). An advanced directive includes a living will that specifies his end-of-life medical treatments and appoints a health-care proxy to make medical decisions if he becomes incapacitated. In addition, you should also make a do-not-resuscitate (DNR) order. Your uncle’s doctor can help you with this.
You should also pre-arrange his funeral, memorial service, and burial or cremation.
Immediately After Death
Once your uncle dies, you’ll need to get a legal pronouncement of death. If no doctor is present, you’ll need to contact someone to do this.
If he dies at home under hospice care, call the hospice nurse, who can declare his death and help facilitate the transport of the body.
If he dies at home without hospice care, call your uncle’s doctor. You’ll then need to call the funeral home, mortuary or crematorium to pick up the body. If your uncle is an organ or tissue donor, contact the funeral home or the county coroner immediately.
Within a Few Days
If funeral plans were not pre-arranged, you’ll need to make arrangements and prepare an obituary. If your uncle was in the military or belonged to a fraternal or religious group, you should contact those organizations too, because they may have burial benefits or conduct funeral services.
You should also notify family members, close friends and his employer if he was still working, and make sure his home is secured.
Up to 10 Days After Death
To wind down your uncle’s financial affairs, you’ll need to get multiple copies of his death certificate, which are typically ordered by the funeral home.
If you’re the executor of your uncle’s estate, take his will to the appropriate county or city office to have it accepted for probate. And open a bank account for your uncle’s estate to pay bills, including taxes, funeral costs, etc.
You also need to contact your uncle’s estate attorney if he has one; tax preparer to see if estate or final income taxes should be filed; financial advisor for information on financial holdings; life insurance agent to get claim forms; his bank to locate and close accounts; and Social Security, the VA (if he’s a veteran) and other agencies that provided benefits in order to stop payments.
You should also cancel his credit cards, delete or memorialize his social media accounts and, if relevant, stop household services like utilities, mail, etc. His home and personal belonging will also need to be dealt with in the coming weeks.
Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of “The Savvy Senior” book.

Stitt Appoints Jay Snider of Cyril as 2023-2024 Oklahoma State Poet Laureate

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Oklahoma State Poet Laureate Jay Snider of Cyril.

Jay Snider of Cyril, Oklahoma, has been appointed by Governor J. Kevin Stitt to serve as the 2023-2024 Oklahoma State Poet Laureate. Snider is an award-winning cowboy poet and recording artist who has appeared at national and regional events. He is widely recognized in the Oklahoma cowboy poetry community and is a frequent contributor to programs presented by the Chisholm Trail Heritage Center in Duncan, Oklahoma.
“It is an honor to appoint Jay Snider as the 2023-2024 Oklahoma State Poet Laureate,” said Governor Stitt. “Jay is a creative and talented Oklahoman, who has combined his love for our state and western heritage with his passion for poetry, and I look forward to this cowboy poet carrying on Oklahoma’s tradition and sharing his talent across the state.”
Oklahoma Arts Council Executive Director Amber Sharples said, “Oklahomans everywhere will connect with Jay’s poetry and stories as someone who fully embodies the spirit of the American West and cowboy way of life. Jay has received numerous recognitions throughout his years of writing, recording, and presenting poetry, but perhaps most compelling is how highly he came recommended by many people across the state. We look forward to working with Jay as we offer funding to schools and organizations interested in bringing the Oklahoma State Poet Laureate to their community.”
“It is an extreme honor to have been considered for the appointment of Oklahoma Poet Laureate,” said Snider. “The great state of Oklahoma has a rich history, and much of our heritage has been passed down through generations as oral history and through the writings of great authors. I have been fascinated by the storytellers of the past, the “Old Timers,” if you will. I felt the need to listen to those stories and hopefully keep them alive. Often, when the ‘Old Timers’ are gone, the stories are gone. Poetry has helped keep the old stories alive. Through the Oklahoma Poet Laureate position, I can continue to promote all types of poetry and storytelling in the great state of Oklahoma.”
Among national and regional events featuring Snider, he has appeared at the National Cowboy Poetry Gathering in Nevada, the Texas Cowboy Poetry Gathering, the Arizona Cowboy Poets Gathering, and the Cochise Cowboy Poetry and Music Gathering. Snider was a featured poet at the Red Steagall Cowboy Gathering for many years. In 2001, he was chosen by CowboyPoetry.com as their fifth Lariat Laureate—awarded to poets whose work celebrates and preserves stories honoring Western heritage and the work of ranching and rural life. In 2006, Snider earned Cowboy Poetry Recording of the Year from the Academy of Western Artists for his CD, “Of Horses and Men.” In 2008, he was recognized as Cowboy Poet of the Year by the Academy of Western Artists. His latest album, “The Old Tried and True,” is a compilation of his favorite poems written by cowboy poets of the past.
Born and raised in a ranching and rodeo family in southwestern Oklahoma, Snider rodeoed as a young man. He currently stays busy raising ranch horses and cattle and taking part in team roping.
The tradition of officials conferring poets laureate to make public appearances and promote a greater appreciation of poetry originated hundreds of years ago. A United States Poet Laureate is appointed by the Librarian of Congress—Tulsa resident Joy Harjo, the first Native American and Oklahoman to hold the position, recently completed an unprecedented third term as U.S. Poet Laureate. Oklahoma’s poets laureate tradition dates back to 1923. The appointment of an Oklahoma State Poet Laureate by the Governor of Oklahoma was codified into state law in 1994. The statute calls for an appointment every two years. Joe Kreger of Tonkawa served as the 2021-2022 poet laureate.
The Oklahoma Arts Council serves on behalf of the Office of the Governor to solicit and facilitate recommendations for the honorary position. The agency supports the work of the Oklahoma State Poet Laureate by promoting their work and making grants available to eligible entities to present readings and programs featuring the laureate. Organizations and schools interested in presenting Snider can learn more at https://arts.ok.gov/.

https://stopswithme.com/

Moving a Loved One Into a Nursing Home: How to Prepare

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It’s never easy to move your loved one to a nursing home. It’s a big deal in every family, and it can be a rather difficult process for all the family members. Even when finances are not an issue, the emotional distress and rejections are making it more difficult. It starts from the moment you realize you can no longer take care of your senior family member, and need to seek help. No matter how hard you try, it’s not always possible to dedicate the time and attention they need to feel safe and happy. The next issue is the acceptance of the senior to go to the nursing home. Some of them may refuse to do it at first – and this guide will help you go through all the steps. Here‘s how to prepare for moving a loved one into a nursing home and making it a smooth and pleasant experience for everyone.

Reasons why your loved one may feel better at a nursing home
Many people feel guilty about moving their senior family member to a nursing home. However, they shouldn’t feel that way as many Oklahoma facilities offer a much better and safer lifestyle for seniors. If you’re still not sure if that is the right decision, remember the following benefits your senior can enjoy:
* Constant supervision and care – if your senior loved one has lived alone until now, you know all the moments of worry when you leave their home. In a nursing home, you can have constant care and support, even when you’re not around. This is a lot safe option than leaving them alone when you’re out at work or taking care of the kids, etc.
* You can still participate in their care – moving a loved one to a nursing home doesn’t mean you abandon them. You can still actively participate in their care and be a big part of their daily routines.
* Socialization – with other seniors living at the facility, your loved one can enjoy socialization more than they could do at their own home. The feeling of loneliness is common for seniors, even the ones who live with their families. Spending time with people of similar ages can be very motivating for them, and it can help with the signs of dementia. Living alone has been shown to worsen such conditions, which is why socialization and participating in activities can be very helpful.
If you simply don’t have time to take good care of your senior loved one, a nursing home can be very helpful and beneficial for their physical and mental health. Now let’s see what steps to take before the arrival at a nursing home.

Moving your loved one to a nursing home – ways to prepare for a smooth process
This important life event is something you need to do properly to avoid unpleasant situations and negative feelings with your loved one. Here are some tips that will help you ease the transition and help everyone accept the changes.

Make plans
Planning ahead is the key to making the process predictable and therefore less unpleasant. Depending on the condition of the senior, try to include them in the process as much as possible, but without burdening them with too many details. Decide if they are capable of making certain decisions and participating in the process, so you can do this together and make the transition easier. Talk about the things they’ll bring, communication routine, plan the visits, etc. Ensure they know you’ll still participate in their life as much as possible. Furthermore, Best Cross Country Movers suggest you deal with the moving details as early as possible, so you can prevent common mishaps that happen in this process. Scheduling the move, hiring an expert team, packing – all of these are tasks that require energy and time, so be sure to deal with them as early as possible.

Expect negative feelings
It’s okay for everyone to feel discomfort when it comes to moving to a nursing home. Seniors don’t like change, and moving to such a facility can also bring feelings of abandonment. You should try to stay patient and positive, and tell all the benefits this move will have. Be optimistic no matter what, and always remind yourself that you’re doing this for their good. However, if you notice some behavioral problems that don’t seem to go away, seek help from a specialist.

Get all the necessary information
Prepare for the transition by learning all the details about the nursing home. With about 300 nursing homes in Oklahoma, make sure you pick the one that fits your senior needs and has a convenient location. Don’t be afraid to ask questions, even the ones about small details such as meals, activities, professional staff, other seniors, etc. Knowing more about the facility will give you peace of mind and reassure you you’re doing the right thing.

Provide all the information
One way to get your senior ready for moving into a nursing home is to make a file with all the necessary details about them. This can be the history of their health, necessary medical documentation, and even photos of important people and moments in their life. These details will help the staff in the nursing home to get to know them, start a conversation and ensure they feel more welcome and familiar. Make sure to mention all the details about their physical and mental health that can help the staff react in case they notice anything unusual later on.

Ensure a safe relocation
Moving to a nursing home can be as complex as any other relocation. Make sure you find experts in this field so you can experience minimum stress and worry related to this Oklahoma interstate move. Trust experts with moving tasks so you can focus more on supporting your loved one and helping them pack and travel safely to an

Be understanding
It takes up to 6 months for a senior to adapt after moving your loved one into a nursing home. This period can include different reactions such as loss of appetite, feelings of sadness, and complaining. Try to be as patient and understanding as possible, and stay alert for more serious signs of depression or anxiety. If there are any concerns, make sure you talk to the staff and see if you can seek for mental health specialist at the facility. Being involved and attentive will make the transition a lot easier and safer, with your loved one knowing you’re there even after moving to a nursing facility.
Meta: Learn how to prepare for moving a loved one into a nursing home and make the transition as smooth as it gets, making sure both you and your senior feel good about the changes.

SPECIAL TO SNL: Hormone Replacement: Yes, No, or Maybe?

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Christina fell in love with gerontology largely because of the experiences with her grandmother. (Photo provided)

Christina Sibley, EMT/RMA, Bachelor of Science- Health Studies

Hormone replacement therapy (HRT) has been a subject of debate for decades, with both sides of the fence claiming harms and health/longevity benefits of taking or leaving it. That can leave women, in particular, at a loss when trying to make an informed decision. Why is it so difficult to get a definitive answer?
In short: hormones, and their effects on the body are complicated and studies tend to concentrate on one or two hormones at a time, usually synthetic, like estrogen and progesterone. Results vary across studies, or even in the same study, when data is analyzed using different variables.
The Women’s Health Initiative (WHI) study is an example of this. A report was sent out in 2002 by the WHI that HRT showed increased risk of certain cancers and cardiac events. Because of that release, prescription and use of HRT plummeted shortly after. Their final report in 2013, after reassessment of study data and addition of new data, showed risk results depended greatly on age and/or time HRT was started post menopause.
Many studies, including the WHI study, only look at estrogen alone or in combination with progesterone, usually synthetic or animal based. They generally don’t consider testosterone (T) at all, which women also produce and is widely available in the body prior to menopause, especially surgical. Additionally, there’s much debate over using synthetic HRT vs bio-identical (plant based) HRT, which is not currently FDA approved. The most effective method of delivery (oral, injectable, creams/gels, patches, or implanted pellets) is also debated, further complicating the issue.
Where does that leave us now? The general consensus, according to the WHI, and other studies, is that in otherwise healthy women, benefits outweigh risks, especially if started closer to the beginning of menopause (natural or surgical). The decision should be made on an individual basis, by the patient and their physician, considering the health history and risk factors of that person.
Christina Sibley, with Sibley Insures, is a licensed health insurance agent who specializes in Medicare plans, all types, and Medicare education. Call (405) 655-6098 or visit https://www.sibleyinsures.com/.

TINSELTOWN TALKS: Bill Mumy: More than ‘Lost in Space’

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Bill Mumy and Jimmy Stewart in Dear Brigitte - Twentieth Century Fox
Cover of Bill Mumy’s new book – from publisher
Bill Mumy and Jonathan Harris in Lost in Space – CBS

By Nick Thomas

With a new 400+ page autobiography recently published, Bill Mumy’s “Danger Will Robinson: The Full Mumy – A Memoir” is crammed with fascinating facts and stories recalling his long acting and musical career (see www.NCPBooks.com).
“‘Lost in Space’ is definitely covered and certainly Will Robinson is the character most people identify with me,” said Mumy from Los Angeles. But despite the book’s title, the author examines much more than just the galaxy-wandering Robinson family.
Riveted to his own family’s black and white television screen of the late 50s, 4-year-old Billy longed to emulate his favorite TV adventurers such as Superman, the Lone Ranger, and Zorro, even breaking a leg after leaping fearlessly off his bed in full crusader mode and landing hard unlike his more nimble black-capped hero. But he carried that enthusiasm into his youthful acting career that would soon flourish.
Ironically, Mumy ended up working alongside his Zorro idol – Guy Williams – who would play space dad to the adventurous boy astronaut who ‘saved the day’ on many occasions beginning with the first season of “Lost in Space” in 1965.
Riding high on the success of earlier roles in popular 60s series such as “The Twilight Zone” and “Alfred Hitchcock Presents,” 1965 proved a particularly good year for little Billy, not yet a teenager, that included guest-starring roles in beloved TV classics such as “I Dream of Jeannie,” “Bewitched,” and “The Munsters.”
That year, the young actor also portrayed a key character in the Twentieth Century Fox film “Dear Brigitte” starring Jimmy Stewart.
“(He) was the best overall artist I ever worked with,” recalled Mumy. “He truly was a wonderful man and showed me how you strive to be a good actor and to treat your coworkers well. The vast majority of actors and directors I worked with as a child were very happy with me because I always knew my lines and got things done quickly.”
While he experienced few professional ‘horror stories’ during his career, an exception was Alfred Hitchcock who terrified 7-year-old Billy on the set of “Alfred Hitchcock Presents.” Mumy says the director apparently whispered in his ear during a scene to stop shuffling about or he would nail his feet to the floor!
Beyond acting, Mumy has worn many hats including those of musician, singer, songwriter, author, and voice actor (see www.billmumy.com), but still recognizes the nostalgic value “Lost in Space” has for fans who grew up in the 60s. It’s hardly surprising, therefore, that Mumy included the name of his plucky young space adventurer in the new book’s title.
“Every child has a gift and mine from an early age was being able to easily memorize a script and deliver the dialogue believably,” he says. “I loved being little superhero Will Robinson. As a child actor, he was everything I ever wanted to be.”
Nick Thomas teaches at Auburn University at Montgomery, Ala, and has written features, columns, and interviews for numerous magazines and newspapers. See www.getnickt.org.

https://belmontcove.com/

OMRF receives $469,000 to study hearing loss

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Oklahoma Medical Research Foundation scientist Gaurav Varshney, Ph.D.

An Oklahoma Medical Research Foundation scientist hopes a new, two-year grant will help him pinpoint the genetic variants that can cause age-related hearing loss.
Scientist Gaurav Varshney, Ph.D., will receive $469,000 from the National Institute on Deafness and Other Communication Disorders, a part of the National Institutes of Health.
Varshney’s lab studies human disease through zebrafish. More than 80% of human genes known to be associated with disease have a counterpart gene in the paperclip-sized fish.
In the U.S., hearing loss affects 1 in 8 people ages 12 and older, according to the NIH. The numbers rise as we age, with 1 in 3 experiencing hearing loss among those 65 to 74 years old.
Genetic causes account for up to half of all hearing loss cases, Varshney said. Scientists have narrowed the possible responsible genetic variants to about 100 mutations through genomewide association studies.
One such U.K. study, published in 2019, analyzed the DNA of 250,000 people between 40 and 69 years old with diagnosed and self-reported hearing loss. That study identified 44 regions within the DNA where one or more genetic mutations could cause hearing loss.
Humans and zebrafish share 39 of those 44 regions. Those 39 areas will be the focus of Varshney’s research.
“We want to pinpoint the specific genes within those 39 regions that could be responsible for hearing loss,” he said. “With that information, scientists can design better treatments for the condition.”
Varshney’s lab will use the gene-editing tool CRISPR/Cas9 to turn off individual genes within a given DNA region in the fish. To determine whether that missing gene results in hearing loss, his team will track fish behavior immediately after generating a startling sound. He’ll then repeat this process for genes in all 39 regions.
“Dr. Varshney’s research is a critical step, and it’s representative of how genetic studies often work,” said Patrick Gaffney, M.D., who chairs OMRF’s Genes and Human Disease Research Program. “You narrow the list of potential mutations until one day, hopefully, you can target a specific mutation with a drug therapy. That’s the direction his research is headed.”
Varshney’s grant is 1R21DC020317-01A1.

https://scissortaildermatology.com/

SN&L TEMPLATE 32 PAGE 01-01-23 cartoons

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https://www.harborchase.com/

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