OMRF Receives $3.4 Million to Study Muscle Loss in Aging
The National Institutes of Health has awarded the Oklahoma Medical Research Foundation $3.4 million to study age-related muscle atrophy and weakness.
The five-year grant follows a discovery by OMRF scientists Holly Van Remmen, Ph.D., and Jacob Brown, Ph.D., connecting age-related muscle loss called sarcopenia to a missing nerve signal.
Most people begin to experience progressive loss of muscle mass and strength in their 30s or 40s. The condition becomes more pronounced after age 65, leaving older people susceptible to falls and difficulty performing daily tasks.
“It’s just a natural process of aging, and some people lose more muscle mass and strength than others,” said Brown, a scientist in Van Remmen’s lab.
While inactivity is the most common contributor to sarcopenia, Van Remmen’s team has shown another cause: denervation, which is an interruption in communication with the nerves that connect muscles to the spinal cord. (STORY CONTINUES BELOW)

In recent work published in the journal Redox Biology, Van Remmen and Brown found that muscle makes a metabolite during denervation that leads to muscle atrophy. Metabolites are the products of chemical changes within a cell.
With the new grant, the researchers will study whether blocking the production of this metabolite protects against age-related muscle atrophy in research models.
“This is a novel area of research that we hope will lead to new possibilities to design much-needed pharmaceutical interventions,” said Van Remmen, who holds the G.T. Blankenship Chair in Aging Research. “Ultimately, we hope this path of research will extend the time that older adults can remain healthy and active.”
Without current drug options to treat sarcopenia, Van Remmen added that it’s important for older adults to ward off its progression by staying physically active and maintaining a healthy diet.
“Simple strength and resistance training paired with a diet that includes adequate amounts of healthy proteins can make a world of difference in maintaining muscle mass,” she said.
TINSELTOWN TALKS: Adrienne Barbeau – from musicals to monsters
By Nick Thomas

Before “Grease,” the hit 1978 movie, there was “Grease” the musical theater production first performed in Chicago in 1971 before moving to Broadway a year later for over 3,000 performances.
Adrienne Barbeau, who played Rizzo during the first five months of the show’s run, helped commemorate the 50th anniversary of the production as a co-editor of the 2022 book: “Grease, Tell Me More, Tell Me More – Stories from the Broadway Phenomenon That Started It All.” It features personal anecdotes from the Broadway cast and crew.
“It stemmed from a Zoom meeting that the original cast had when the pandemic first shut everything down,” recalled Barbeau from her home in Los Angeles. “The stories everybody told were just so delightful and touching and funny and most of them all new to me because I left the show early on.” (STORY CONTINUES BELOW)

Barbeau and two others involved in the production began assembling the stories.
“We sent out a questionnaire to over 100 actors, musicians, and crew members who had been involved in the show asking them to write down their stories of working on the production,” said Barbeau. “We put it all together in a terrific tribute to the show.”
Despite her strong connection to “Grease” which opened on Valentine’s Day, 1972, to this day Barbeau still has not watched the popular 1978 movie version which has many differences, including some of the music, from the original play.
“I happened to hear one of the songs from the movie a long time back, which was one of my songs,” she recalled. “It was lovely what they had done with it, but it just was not what we had done. So, I decided never to watch the film so I could keep the memory of our show and not cloud it with another version.”
Though her career began in musical theater, Barbeau left “Grease” to co-star in the TV comedy “Maude” throughout the 70s. But in the early 80s, the actress starred in several horror/sci-fi films (“Swamp Thing,” “The Fog,” “Escape from New York,” “Creepshow”) forever cementing her movie status as a horror sex symbol (see www.abarbeau.com).
“I started out in musical theater and comedy, and the transition to more dramatic roles was never by design,” Barbeau explained. “It’s just that somebody offered me something I wanted to do or needed to do to pay bills. I ended up playing strong women who were not victims and they were often interesting and challenging roles.”
“People always say, oh you were a sex symbol,” she adds. “But I like to remind them my first love scene in film was with a swamp monster!”
Nick Thomas teaches at Auburn University at Montgomery, in Alabama, and has written features, columns, and interviews for numerous magazines and newspapers. See https://www.getnickt.org/.
Hospital administrators elected to Oklahoma Hospital Association Board of Directors


RIGHT: Richard Lofgren, MD, chief executive officer, OU Health. Elected to an at-large position.
Three Oklahoma hospital administrators were recently elected to the Oklahoma Hospital Association (OHA) board of directors for the 2023-2025 term.
Elected to at-large positions are Richard Lofgren, MD, chief executive officer, OU Health; Tim Pehrson, president and CEO, INTEGRIS Health; and Krista Roberts, chief executive officer, St. Mary’s Regional Medical Center, Enid.
Tammy Powell, president, SSM Health St. Anthony Hospital – Oklahoma City, enters her second year as chair of the board. Others serving on the board’s executive committee are Denise Webber, chair-elect, president/CEO, Stillwater Medical Center; Jay Johnson, immediate past chair, president/CEO, DRH Health, Duncan; and Daryle Voss, at-large executive committee member and southeast region chair, president and CEO, Mercy Hospital Ardmore. (STORY CONTINUES BELOW)

Continuing their terms as regional chairs on the OHA board are Kandice Allen, northwest region chair, CEO, Share Medical Center, Alva; Jim Gebhart, Oklahoma City region chair, community president, Mercy; Jonas Rabel, northeast region chair, chief hospital executive, INTEGRIS Miami and Grove hospitals; Michael McBride, Tulsa region chair, regional president and chief operating officer, Ascension St. John Medical Center, Tulsa; and Brent Smith, southwest region chairman, Comanche County Memorial Hospital, Lawton.
Continuing as at-large members are Charles Grim, secretary of health, Chickasaw Nation Department of Health, Ada; Richie Splitt, president and CEO, Norman Regional Health System; and Bennett Geister, CEO, Hillcrest Hospital South, Tulsa.
Corey Lively, CEO, Great Plains Regional Medical Center, serves as the American Hospital Association delegate to the OHA board; and Steven Crawford, MD, chair of the department of family and preventive medicine, OU College of Medicine, serves as the physician member.
Hospital systems announce layoffs
Story by Bobby Anderson, RN, Staff Writer
The new year has brought a new round of hospital layoffs as healthcare systems nationwide deal with surging labor costs, shortages, and declining revenues.
Locally, the first two weeks of January saw layoffs from Integris Health as well as OU Health.
Integris announced it was cutting some 200 positions while OU announced an equal number of layoffs.
In a statement, OU health announced the layoffs would coincide with its planned restructuring.
“As part of the redesign, OU Health will move from a holding company to an operating company structure with duplicative services and positions being eliminated,” the statement read. “An estimated 200 positions will be reconfigured to the new structure, which integrates the organization into clinical business.”
Integris Health announced its reduction would be the result of a combination of cuts.
“Financial challenges are multifold, but some include a dramatic rise in expenses due to labor shortages and supply-chain disruptions, and significantly lower patient volumes compared to pre-pandemic days,” the statement read.
Integris laid off 140 positions and cut 60 vacant jobs, according to a spokeswoman.
The healthcare industry has suffered from nursing shortages and the winter’s omicron surge, forcing many organizations to turn to contract workers demanding higher rates.
The loss of Covid subsidies from the federal government also impacted the ability to keep up with rising labor costs.
Many systems find themselves in a counter-intuitive role of both cutting positions while trying to recruit and retain nurses.
OU Health announced its organizational redesign to complete the integration from its historic merger on July 1, 2021.
OU Health was created as the flagship comprehensive, integrated academic health system to improve the care and outcomes for all Oklahomans. As the state’s academic referral health system, OU Health plays the unique role of providing critical specialty services with access to advanced technology and expertise.
“OU Health needs to support and enhance the capabilities of the state’s vital rural and regional hospitals as the flagship academic referral center. All care that can remain in a community should remain local, but if the patient needs a higher level of care, OU Health is here to serve,” said OU Health President and CEO Richard Lofgren, M.D., MPH.
The organizational redesign and operational restructure will enable OU Health to improve efficiencies and grow its impact in the state and region as well as create a highly integrated, modern clinical platform, one that serves even more Oklahomans.
“In order to grow and adapt to industry changes, we need to perform in terms of the quality of our services, patient experience, and the efficiency and effectiveness of our processes,” Lofgren said. “Oklahoma needs the unique specialty and sub-specialty services we provide. We are positioned with dedicated physicians and staff to fully realize our special mission of clinical care, education, and research. We are committed to our role of continuing to improve the care and outcomes for the region and beyond.”
Both health systems are still actively hiring bedside nurses offering both recruitment and retention bonuses.
INTEGRIS Health Celebrates 35 Years of Kidney Transplantation
INTEGRIS Health is celebrating 35 years of kidney transplantation. Surgeons with the INTEGRIS Health Nazih Zuhdi Transplant Institute have performed more than 2200 kidney transplants since the program began.
The INTEGRIS Health Kidney and Pancreas Transplant Center offers superior outcomes for kidney transplants from both living and deceased donors. It consists of one of the largest and most experienced transplant teams in the United States.
E.N. Scott Samara, M.D., is the surgical director of kidney transplant at INTEGRIS Health Baptist Medical Center. He conducted the first kidney transplant at the facility and still practices today. He is proud of what the program has accomplished through the years
“I have been grateful to see over 2000 patients be able to avoid or stop dialysis and live normal productive lives,” says Samara. “In the last 15 years, I have even been able to work with my son, Dr. Shea Samara, and Dr. Jose El-Amm, who is the medical director of kidney transplant and like a son to me, which has been both professionally and personally fulfilling.”
Every ten minutes another person is added to the national transplant waiting list. Of those, 82% are in need of a kidney. There are more than 90,000 people in the United States waiting for a kidney donation. The average wait time for a kidney is three to five years from a deceased donor. With living donation, a patient may be able to receive a transplant much faster. To learn more or schedule an assessment, call 405-949-3816.
FEBRUARY OKLAHOMA CALENDAR OF EVENTS
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TRAVEL/ENTERTAINMENT: B is for Baltimore, Maryland
From Terry “Travels with Terry” Zinn t4z@aol.com
text and photo provided by the Oklahoma Historical Society


You could say that Baltimore is a city designed for Senior leisure. The hop on and off water taxi around the bay is an ideal way to see a lot of the area’s attractions with a minimum of exertion, as it stops at many attractions. The minimal fee is good for the entire day. The small boat captains are eager to answer area questions as to where to eat and museum times. Note, many museums and attractions are closed on Mondays and Tuesdays.
Of course it stops at historic Ft Mc Henry – famous for the inspiration of the Star Spangle Banner composition. (www.nps.gov/fomc) You have to change boats to go the extra distance, but worth the convenience, when you think of the inconvenience of getting a taxi or uber to take you to the far out bay point. The preserved and reconstructed brick fort is informative if you have never visited a fort of this generation. It’s humbling to stand in the area that inspired America’s Anthem.
Once there it’s always good to schedule your visit with a tour by a park ranger for details of the fort. If not, the film is always inspiring, if not a bit nostalgic ,when at the end of the movie, a curtain opens to let you view through a large picture window the Fort in the background as the National Anthem plays.
Back in the downtown area is the Flag House where the American garrison size flag was created. Besides the history of the flag you can take a self-guided tour of a small period house, complete with furniture and staging of the time.
For pure entertainment, although you can’t help but learn something, is the national aquarium centrally located at the base of the Inner Harbor. (www.aqua.org) All levels of this multilevel aquarium is easily accessible with riding the multiple escalators, or if needed there is an elevator. Hosting over 20,000 aquatic animals with a Backtip Reef and Living Seashore, and a couple of large screen animal related movies, and a live dolphin show, make the aquarium one of the Inner Harbors best attraction. Of course they host a extensive gift shop with snack bar.
When you’ve got to eat, Baltimore with its vast seafood menus offers many venues. The off the beaten track funky Little Havana Bar and Grill offers many seafood based foods along with an extensive bar and their famous large Mojito.
Phillips Seafood (www.phillipsseafood.com) is a Baltimore tradition. They offer an upscale indoor or outdoor dining experience with reservations recommended. Their 8 ounce Crab Cake Extreme with Mac and Cheese, made with pure Jumbo Lump Crab with no fillers, is served in a skillet, and guaranteed to fill your Crab Cake desires. ($50.00)
If you plan to visit the Baltimore Museum of Art, be sure you check its times, as it is closed on Monday and Tuesdays. While it was closed the days I was in Baltimore I made sure I dined at Gertrude’s, where the Museum of Art displays culinary arts, under the expert guidance of owner, John Shields, is a must. Shields is a veteran TV host, and author and is called the “Culinary Ambassador of the Chesapeake Bay” with the restaurants opening in 1998. Gertrude’s is Shield’s tribute to his grandmother, Gertie. Shields is a personable entrepreneur and you may want to pickup one of his cookbooks including the 25th anniversary, “Chesapeake Bay Cooking.” Many menu options looked appealing but I chose the Irish Salmon, flown in to Gertrude’s several times a week. This is an example of the attention paid to the high standards that has made John Shield’s reputation.
An evening dining cruise aboard the Spirit of Baltimore, is a relaxing way to see more of the bay’s landscape while enjoying a buffet and beverages served by congenial staff. The cruise departs from the west wall of the harbor and cruises the Inner harbor along the Patapsco river, and includes glimpses of Fort Mc Henry. Come prepared for a casual and enjoyable evening, mixing with other tourist and those celebrating special occasions (www.spiritcruises.com/Baltimore).
While visiting the Fells Point area of the harbor you may want to stop in to the upscale Sagamore Hotel for a respite and beverage, or if your budget allows overnight accommodations. For a budget minded traveler the Days Inn Inner Harbor (www.daysinninnerharbor.com), about 3 blocks away from the harbor, and near the Horseshow Casino Baltimore, Ravens Stadium, and Oriole Park at Camden Yards, can fulfill your travel needs.
As you can guess there is much more to discover in Baltimore than I could cover in just two days, so historic and friendly Baltimore may require repeat visits (http://baltimore.org/).
Husband and Wife Duo Provide Multigenerational Care in Oklahoma City

For physicians Mitch and Kristin Earley, every day is take your spouse to work day. In clinic, they often go by Dr. Mitch and Dr. Kristin to avoid any confusion among patients. He is enthusiastic about men’s health, and she loves women’s health. Together, they provide the whole range of expertise to their patients after recently joining Mercy Clinic Primary Care – Northwest Family in Oklahoma City.
The Earleys met in medical school at Des Moines University’s College of Osteopathic Medicine when Dr. Mitch was going into his third year and Dr. Kristin was entering her first year.
“Our family has taken care of a lot of other families over the years, which has been very rewarding,” said Dr. Mitch.
Combined, Dr. Mitch and Dr. Kristin have over 42 years of experience in medicine. Sometimes patients overlap, which provides a unique experience for those receiving care and their families. As patients grow, Dr. Mitch tends to treat more of the men and Dr. Kristin sees more of the women and children. (STORY CONTINUES BELOS)

“Family medicine is a great field because we have the privilege of caring for multiple generations of families,” said Dr. Kristin. “When you treat the whole family, you have a better understanding of your patients’ health, living and family situation. It completes the picture and allows us to provide personalized and informed support.”
Treating multiple generations of families has also led to some memorable moments. Dr. Mitch said, “I remember one of my patients gave me a hand-drawn picture, and as I tried to figure out what it was, I learned it was multiple generations of family members that either I or my wife had helped take care of in this little girl’s family, which was a fun thing to see.”
Both physicians appreciate providing general family medicine to any patient, regardless of age or gender. Preventive care is also an essential part of their treatment philosophies.
“I’ve wanted to be a physician for as long as I can remember. I was fascinated by how the body worked as a child, and as I pursued my education and career, it developed into an interest about how the whole person works,” said Dr. Kristin. “I want to create a partnership with my patients so we can better their quality of life together.”
In addition to general and men’s health, Dr. Mitch also provides sports medicine expertise to his patients.
“One aspect of family medicine that challenges me is figuring out a diagnosis and then determining the best course of action for a patient,” said Dr. Mitch. “I also really enjoy the diversity of patients that family practice provides. I can practice a variety of skills that helps improve a patient’s life.”
When they are not caring for patients, the Earleys enjoy sports, travel, music, cooking and trying new foods.
Schedule online with Dr. Mitch at https://www.mercy.net/doctor/mitchell-l-earley-do/ and with Dr. Kristin at https://www.mercy.net/doctor/kristin-frady-earley-do/.
SNL CENTENARIANS OF OK
Annie Laurie (Ivey) Whited

Annie Laurie (Ivey) Whited of Noble was manager of the gift & book shop at the OU Continuing Ed Center before retiring in 1984. She attended Crosspointe Church in Norman and was a member of the Army Officers’ Wives Club. Annie’s words of wisdom: “Love the Lord, exercise, eat well and love others!”
Anna Lee Kurtz

Anna Lee Kurtz of Oklahoma City is now a centenarian. She attended and volunteered at Catholic churches wherever she lived, volunteered with Meals on Wheels and the Homeless Shelter. Anna says “Stay active, be positive and always be willing to help others!”
LaVerne Cox Tucker

LaVerne Cox Tucker of Sweetwater actively engages in her hobbies of reading, quilting & crocheting. She resides in the house built at the turn of the century that she moved into as a new bride & is involved with the decisions of the farming & ranching with her son & grandson. The Tucker Home Place was declared an Oklahoma Centennial Farm in 2022. Four generations of Tuckers have farmed the 160 acres. LaVerne’s life advice: “Be honest and be true!”










