Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis.
But a new discovery from Oklahoma Medical Research Foundation scientist Rheal Towner, Ph.D., offers new hope in fighting this deadly cancer, which claimed the lives of Sens. John McCain and Ted Kennedy.
In pre-clinical experiments at OMRF, Towner discovered that a protein called ELTD1 is present in the most aggressive glioblastoma tumors. Towner then tested how the tumors would react to an antibody known to counteract the effects of ELTD1.
He found that the compound slowed the process of angiogenesis, the growth of new blood vessels, which is key to tumors’ ability to spread and kill.
“This drug seems just as promising, if not better than, what is currently considered the standard of care,” said Towner. “Few therapies exist for treating glioblastoma, but this could provide a step in the right direction.”
If proven effective in further trials, said Towner, “This could provide overall treatment with fewer side effects and better results than we see in current drugs.”
The new findings were published in the journal NeuroOncology.
Towner will continue to look for ways to use the new treatment in combination with other drugs to boost their effectiveness and better target tumors.
“One problem with drug treatments for tumors is that it’s hard to get the drug to the tumor site,” he said. “If we can regulate that process with targeting ELTD1, we might be able to use it to deliver other drugs directly to the tumor and, hopefully, eliminate it.”
If researchers succeed with this tumor-targeting method, Towner said they will begin testing it on other tumors associated with breast, pancreatic or other cancers.
Funding for this research was provided by National Institute of General Medical Sciences, grant number 5P20GM103636-02, and Institutional Development Award (IDeA) from the NIGMS, grant number 5P20GM103639. The NIGMS is part of the National Institutes of Health.

WALK BY FAITH, By Lisa Sydnor

Volunteers are the life-blood of non-profits. They may serve as board or advisory council members, in janitorial or maintenance positions, clerical, fundraisin, communications or as stockers in a food pantry. In other words, any position within the organization. On April 19, 2018, the Independent Sector, in partnership with IMPLAN, announced that the latest value of a volunteer hour is $25.69 – up 2.2% from 2017. That figure, estimated from data collected in 2017, shows the incredible contributions volunteers make to our communities and our country. Currently, 63 million Americans volunteer about 8 billion hours of their time and talent to improve people’s lives and the natural world. With the new value of volunteer time, these Americans are contributing approximately $197.5 billion to our nation.
When someone says, “I am JUST as volunteer”, they are truly missing the significant impact they have on the nonprofit world.
RSVP – Retired and Senior Volunteer Program – has served Oklahoma County since 1973. In 2017, 130 nonprofits in Oklahoma County were the beneficiaries of 136,700 service hours from 707 volunteers; a financial impact of $2.9 million.
Beth Patterson, Executive Director of RSVP of Central Oklahoma, said that the need for more volunteers is critical to help local nonprofits meet their missions and the needs of their clients. RSVP recruits and trains senior volunteers for agencies, such as; American Red Cross, Ronald McDonald House, Project 66 in Edmond, City Care’s Whiz Kids (tutoring), Upward Transitions Travelers Aid at Will Rogers World Airport, and RSVP Provide-A-Ride.
In 1994, RSVP started Provide-A-Ride, a service providing low-income seniors free transportation to medical appointments. RSVP volunteer drivers, age 55 and older, utilize their own vehicles, choose their own schedules, select the geographic areas they want to serve, receive free supplemental accident and liability insurance, and mileage reimbursement. In 2017, 85 volunteer drivers provided 7,476 rides or 261,660 miles driven to medical appointments for 367 seniors.
Provide-A-Ride participants must be 60+ and schedule rides in advance. Maintaining their independence and dignity, being self-sufficient, keeping medical appointments and becoming friends with the drivers are a few of the benefits participants receive through the program. For the drivers, knowing that they performed a much needed and valued service for someone, ensuring that they get their prescriptions filled and alleviating often burdensome transportation costs is what it is all about.
This program is so successful because of the people; that personal touch. One example is RSVP volunteer driver Pat Nebgen, “I do this to give added meaning to my life; to give back; to share my day with someone. The smiles, hugs and lively conversations are added benefits.” Pat began volunteering at RSVP after the death of his wife of 47 years. And, because of Don Blanding, who began volunteering in January 2017; “I enjoy driving and love that I can help seniors live more independently. I greatly enjoy being a part of RSVP. The elderly seniors that we serve are truly dependent on someone else for transportation to their medical appointments. They are always so appreciative of the help they receive. It makes me feel good to see how thankful they are.”
Some participants have shared their thoughts and appreciation:
· Provide-A-Ride volunteers are angels on wheels. Thank you for your kindness in my time of need. Angie G.
· The volunteer drivers are so friendly and courteous. I feel like I’ve made new friends. Now I look forward to my appointments because of them. Mildred M.
· RSVP Provide-A-Ride has made all the difference in ensuring I get the proper care my doctors want me to have. Jerri B.
· I am 91 and have macular degeneration so I can’t drive anymore. Provide-A-Ride volunteer drivers are my eyes on the road now, and I am so grateful. Ida Jean K.
· Provide-A-Ride is a bright cheery ride for those of us who are not able to drive anymore. Nan G.
· I don’t know what I would do for rides to my doctors without Provide-A-Ride. Loretta A.
· If I didn’t have Provide-A-Ride I wouldn’t be able to go to my medical appointments. Deborah M.
· I’ve lost my husband and children, and I don’t have family close enough to help me. Bless you for caring for us! Billie B.
If you are struggling with having reliable and affordable transportation to medical appointments, call RSVP to learn of your options. If you are looking for an avenue by which to give back to the community, what better way than to provide reliable, free transportation for fellow seniors. This is truly a win/win situation and the bonus is making new friends.
RSVP will recognize approximately 300 volunteers at the Annual Volunteer Recognition Luncheon on April 17, 2019, at the Oklahoma State Fairgrounds Bennett Event Center. Sponsorships are available. To learn more about becoming a Provide-A-Ride participant, find out more about local volunteer opportunities with RSVP, or become a sponsor for the volunteer recognition, call 405-605-3106 or email beth.patterson@rsvpokc.org.
RSVP is a part of the Corporation for National Service and a United Way of Central Oklahoma partner agency.

by Bobby Anderson, Staff Writer

Like many, Karyl James, MSN, BSN, RN, Mercy Hospital CNO watched the frequent headlines marking deadly shootings.
And the reports of violence inside health care showed no signs of slowing down.
But what happens if the two scenarios combined? It was a question James and others in the Mercy system really didn’t want to think about, but one they knew they had to answer.
“With all the public shootings going on our safety team in collaboration with nursing said we have to educate and do something about it,” James said recently.
Through planning, discussion and scenarios Code Roscoe was born.
The code is Mercy-wide, so all 45 hospitals in the system use it for any active shooter situation.
Each unit must have at least two identified safe places that can prevent a shooter’s access to people.
“It’s not just nursing it’s registration, it’s all of those individuals. The front door of the hospital is registration so they need a safe place,” James said.
Planning for the unknown is a constant battle. Knowing who might have a gun is another.
A former ER nurse, James is familiar with both.
“Unknown was just kind of second nature for me and personally, I’ve had a gun pointed at me as an ER nurse many years ago,” James said.
It was an eye-opener to say the least.
“Yeah, I’m going to die. It was frightening,” James said of what flashed through her mind all those years ago. “He was not in his right mind and pulled out the revolver. Luckily, I had a police officer right next to me and he grabbed the gun.”
“The worst we can do is say ‘Oh, that will never happen to me because it might.’”
James knows working without a plan would shortchange everyone. That’s why she’s invested in the planning, hoping it will never be put to use.
The first drill that was run pointed out several instances where locking mechanisms didn’t work the way they should have.
The second time the code was called it wasn’t a drill.
“I got that call on a Sunday afternoon and I just froze,” James said of the scenario where the hospital locked down after a suspect in a nearby neighborhood was seen with a gun. “My stomach just sank because there was no drill.”
Out of instinct the first thing James did was call the house supervisor. That wasn’t protocol.
“The first thing you do is turn your phone off and text only,” James said. “I was the administrator on call.”
The house supervisor did answer and whispered to James she and several others were huddled under a table in the nursing administration offices.
“There was no lock on that door so they had the table pushed against the door,” James said. “The larger space you could just walk in. We’ve since put a badge reader on that door.”
Officials also learned the emergency locking button that seals all doors in the emergency department did not work.
“You could literally walk up and push open our ER so we got that fixed,” James said. “It really kind of opened our eyes to a lot of the safety measures we thought we had but really didn’t.”
Mercy has had Code Roscoe in place for nearly three years now. It’s evolved along the way.
“The reason I feel good about it is because the co-workers feel good about it,” James beamed. “After that actual event I went to the hospital after it was all said and done. It was a grueling 45 minutes because that was about how long it took for police to subdue the individual shooting in the neighborhood. I rounded on staff.”
“They knew exactly what to do. They knew where their safe spots were and the locks worked. They felt safer. For me, that’s a win.”
Planning for the unexpected is challenging to say the least.
“There’s always something new and I think you have to be flexible to understand you don’t have everything figured out and you never will,” she said.
“I get shocked every day with something new. Being open to accepting that and training as much as you possibly can for those bigger events – coworkers will figure out what they need to do and what is right to do for their patients and their safety.”

INTEGRIS is joining other hospitals and health centers around the country in a national effort to produce a stable supply of generic drugs. The venture is designed to address the growing frustration caused by persistent shortages of simple yet vital medications.
Utah-based not-for-profit generic-drug company Civica Rx is spearheading the initiative. “Drug shortages have become a national crisis, with patient treatments and surgeries canceled, delayed or suboptimal,” says Martin VanTrieste, chief executive officer of Civica Rx. “We thank these organizations for joining us to make essential generic medicines accessible and affordable in hospitals across the country.”
The benefit of the Civica Rx initiative is expected to be two-fold. Hospitals will not only have access to generic drugs that are frequently in short supply, but they will also be able to purchase those medications at a reduced cost. A savings that can then be passed along to patients.
“We are excited to be a partnering member in this venture,” says Tommy, Ibrahim, M.D., chief physician executive at INTEGRIS. “We enjoy a proud tradition of being a leading-edge health care provider known for a pioneering spirit that has paved the way for many medical firsts and technological advancements. We believe this initiative is another example of that. It is an innovative approach to providing quality, accessible, more affordable medicine to the citizens of Oklahoma.”
Civica Rx plans to bring 14 hospital-administered generic drugs to market in 2019. The overall vision is to become a model generic drug company that provides high-quality Food and Drug Administration-approved products at affordable prices.

A chocolate Labrador Retriever named Penney and a passion for old maps led to a unique business opportunity.
“I am nearing retirement and decided if wanted to retire to the country where Penney would have a place to run, I would need to have a small business to make ends meet,” said Mike Howard, owner of Penney’s Territorial Maps.
After collecting old maps for many years, Howard began copying them and hanging them up at work and in his home. One thing led to another, and before long people were requesting them.
“We have about 30 shops in northeast Oklahoma who stock and sell the maps,” Howard said. “I have really been surprised at how well the maps have been received… The business is expanding to other states, and I now have dealers in Texas, Arkansas, Missouri and Kansas. I should be in New Mexico and Colorado by the end of 2019.”
Howard reproduces the old maps that are artificially aged and then sets them in rustic wood frames. Howard said he loves the reaction his customers have to his maps.
“I love hearing all the stories about their family’s history, looking for long lost towns, or pointing out where their land run claim was,” he said. “I have learned so much history about Oklahoma just talking to customers about the maps. I feel customers love the maps because it gives them a link to the past.”
Established in November 2016, Penney’s Territorial Maps joined the Made in Oklahoma Program this year. To learn more about the business, visit www.madeinoklahoma.net/products/penneys-territorial-maps/ or find them on Facebook.

By Darlene Franklin

“Why should I be afraid?” Israel’s greatest warrior king, David, asked in Psalm 27.
These past few months, I could have given him a few reasons from the “disease that stalks you in darkness” (Psalm 91:6, NLT) category. It started with a pulmonary embolism that could have taken my life and progressed to a succession of less threatening but still uncomfortable and debilitating ailments, most recently the need for cataract surgery.
Given my propensity to anxiety, I decided to proactively arm myself with encouragements not to give in to fear. When I opened my Bible, I discovered that every time it tells me to not be afraid, it also gives a reason.
If often also gives additional instruments. “Just” do this instead. As I adjust my attitude, my fear level drops.
“Just stand still and watch the Lord rescue you today.” (Exodus 14:13 NLT bold face mine and also in the paragraphs below)
In the words of the Desiderata by Max Ehrmann, “No doubt the universe is unfolding exactly as it should.” Given time, most issues will resolve themselves.
Yes, there are times I’m supposed to get to work or even go on the offensive. But I start by standing still. I’m not in control, and why do I want to be? God is so much more powerful than I am on every level.
“The Lord himself will fight for you. Just stay calm.” (Exodus 14:14 NLT) The phrase “stay calm” follows on the heels of “standing still” in the Bible, suggests the two work hand in hand. “Stand” involves physical action, to maintain an upright position while on one’s feet, without wavering. In this case, “stay” works more like “to be.” I can stand still because I am calm.
“Still” implies calm. I am undisturbed by outside forces, not showing or even feeling strong emotion, e.g., fear.
“Just open your eyes and see how the wicked are punished.” (Psalm 91:8 NLT.)
Take a look at the larger picture. When the doctor told me, I had blood clots in my lungs—not one but two—I was unaware that that I had already passed the first test to survival. I hadn’t died in a heart attack as soon as they developed.
Recently, I spent eight hours in emergency room because of chest pain which turned out to be nothing worse than gastric difficulties. Over the long hours I spent watching the ER fill, empty, and fill again with new patients, I opened my eyes to those in much worse shape than me. I could afford to wait while newborn babies sick from pneumonia cried feebly and accident victims hovered on the brink of life and death.
“Just remember what the Lord your God did.” (Deuteronomy 7:18-21 NLT)
Remember the past. Was I frightened the last time I went through a similar experience? When the doctor warned me that the surgery was very serious, implying “and you could die.” Of course! I was afraid, but at peace—and I survived.
The more often something like that happens, the easier it becomes to remember God’s in control. Whether I live or die, I can trust him. The heart and mind connect what I’m learning from my Bible study and what’s happening in my life more clearly. Past experience increases my confidence that God has a purpose behind the current trial that’s tempting me to fear.
“Just have faith.” (Mark 5:36 NLT)
This guideline feels obvious—except the person who was told to have faith had every reason to doubt. Jairus, a leader in his synagogue, had come to Jesus when his daughter was deathly ill. Before they reached the house, he received word that his child had died.
Jesus’ response to the news? “Just have faith.” Minutes later He raised the girl from the dead. But if I had been Jairus in that moment, I would have felt like screaming, “I had faith. I came to you.” Undercurrent: You failed me.
Jesus encouraged Jairus to continue in the same faith he’d started out with. To trust God even in his bleakest moment. And sometimes I’ll be called on to trust in the face of massive disappointment, impossibility, and personal pain.
The next time fear comes knocking at the door, let’s remember these five principles so we can face those challenges with courage. God is on our side, and He’s always more powerful than what’s happening.

WESTVILLE – A number of years ago, Terry and Pam Lamb began sharing a mustard recipe with friends and family. Now, they’ve created a business out of it.
“After being asked to bottle our lemon dill mustard so friends and family could share it with others, we decided to look into making it a business,” Terry Lamb said. “We had no experience in producing a food product. We looked to our local SCORE office for assistance. They suggested we market more than one product. We started playing with flavors and came up with over 10 we felt would be marketable and decided to start marketing three.”
Partnering with Pam’s mother, Vienna Willard, the Lambs converted their shop into a commercial kitchen. After approval from the Oklahoma State Department of Health, Tajour Specialty Products was ready for production.
“We currently manufacture three flavors of mustard,” Terry Lamb said. “Our flavors include lemon dill mustard, rosemary garlic mustard and cranberry orange mustard. We have a number of other flavors developed with the intention of introducing more flavors as our company grows.”
The Lambs chose to incorporate a Hand Up Program, in which they donate 2 percent of every sale to go into an account to help people in their community build local businesses and fight food insecurity.
“We also try to make our products versatile,” he said. “Our mustards can be spread on a cracker with cheese or used on a sandwich. They can also be used as an ingredient in recipes. Our favorite is to make a dressing out of our cranberry orange mustard by mixing it with equal amounts of honey and using it on a salad or as dip. Making deviled eggs using any of our mustards runs a close second.”
Lamb said the goal is to create flavorful, healthy products without added sugar, salt or fat. Tajour Specialty Products was established in November 2017 and started sales in December 2018. The owner is a member of the Cherokee Nation. Tajour Specialty Products recently joined the Made in Oklahoma Program. To learn more about the business, visit www.tajoursp.com, www.madeinoklahoma.net/products/tajour-specialty-products-llc/ or find them on Facebook.

by Bobby Anderson, Staff Writer

On the darkest days, sometimes all it takes is a single ray of light to turn everything around.
For the last 20 years, Louise Colbaugh, 90, has shined in the Oklahoma City metro, volunteering at metro hospitals.
Colbaugh is closing in on three years volunteering at Community Hospital in south Oklahoma City but before that she gave 17 years at Hillcrest and eventually St. Anthony.
“I enjoyed it,” she said of her decades of unpaid service. “I don’t know. It’s just a way of life after awhile, you get up and go. You don’t sit at home and watch television or whatever.”
Colbaugh stayed home until almost 45, rearing a son and a daughter before heading out into the workforce.
Her son moved on to the paper products industry in Houston. Her daughter is close by in Moore and retired herself.
Her great granddaughter has already graduated college and is going on to pursue her degree as a physician’s assistant.
Attending graduation for her great granddaughter was a moment she’ll never forget.
“Wonderful and proud,” beamed Colbaugh, who also has two younger great grandchildren.
After raising kids and before volunteering she went back to school and studied accounting. She worked in the accounting department at Shepler’s western store.
As her husband’s health faltered, she decided she needed better insurance. She worked at Tinker Air Force Base as a civilian in the accounting department, eventually in the AWACs division.
Numbers were numbers, but only a lot more zeroes were at the end of those military budgets.
Colbaugh and her husband celebrated 51 years of marriage before he passed.
“It was bad,” she said of the end. “He had so many heart surgeries before he died. They tried to do surgery on him again and he never came out of it.”
For most who spend time with a loved one during an extended illness, the hospital would be the last place they would want to spend more time. Too many hours of fear and pain.
Colbaugh ran towards it.
“It’s just a way of life. It’s like another home to me,” Colbaugh said. “It gives you a purpose to get up in the morning. You know you’re going to meet people and you’re going to talk. I just like to do it.”
It’s an opportunity for Colbaugh to pour into others. She has stories to share. She’s felt the same feelings.
“It may be something like getting them a cup of coffee or a warm blanket,” Colbaugh explained. “I enjoy doing it and I enjoy talking to the people. It’s satisfying I can help people.”
“Like I say, it’s a way of life for me now.”
Colbaugh’s journey to Community Hospital began when St. Anthony closed its gift shop. A few of her fellow volunteers made the trip as well.
“Some people they’ll sit home and don’t do anything and then they wonder why they feel so bad,” Colbaugh said. “If they only knew how satisfying it was they would run for it really. That includes men and women. I work with both.”
“And there’s always somebody coming in and they see what you’re doing and they want to volunteer, too, but it’s getting farther and farther in between.”
Community Hospital has two campuses featuring a comprehensive range of medical services offering nursing care in a close-knit, compassionate community.
“You get paid. You get paid with gratitude and the thank-you’s you get,” Colbaugh said. “Men especially say ‘thank you for being a volunteer.’ That just makes me feel good.”
“And Roxy (Kostuck) our manager she is so good to all of us. She has Valentine’s parties and she gave me a 90th birthday party and it was wonderful.”
She immediately used the gift certificate she received to splurge on a cashmere sweater.
Colbaugh typically volunteers every Monday and Tuesday, coming in at 8 a.m. and working until 2 p.m.
She grabs the cart filled with complimentary items and goes room to room checking on patients and their families asking if they need anything.
From there she goes to the surgery waiting room.
“I go in and see what I can do for them,” she said. “And then I come back and Roxy always has something. I wrap a lot of gifts. They give away so much I can’t believe a hospital does that.”
As you might expect, Colbaugh is a big fan of volunteering her time. She’s quick to share her experience when others ask.
“I would tell them they would appreciate coming up here once they started,” Colbaugh said. “It would be good for them and they would get lots of exercise. I think they would love it.”

Brightmusic Chamber Ensemble presents fine classical music in an intimate, family-friendly setting. All concerts will take place at 7:30 pm on Tuesday evenings at the beautiful and historic St. Paul’s Cathedral in downtown Oklahoma City at 127 NW 7th Street (at Robinson). Bright Music website, www.brightmusic.org, contains more detailed information about this concert, including the musicians who will be appearing. Season passes are available online, and individual tickets are available at the door for $20. Admission is free for children and students with student ID and for active-duty military service personnel with ID.
“Reeds-A-Plenty”
Experience the Richness
Tuesday, March 19, 2019, 7:30 pm at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson).
Experience the exquisite richness of woodwinds as the Brightmusic Chamber Ensemble presents a diverse sampling of 18th- through 20th-century works for reeds in its fourth concert of the 2018-19 season Tuesday evening, March 19, 2019. On the program are worthy works by Saint-Saëns and Glinka, as well as three of the worthiest French composers and a Czech you’ve probably never heard of. This is a rare opportunity to hear these delightful but less frequently performed works, some by composers who are best known for their compositions for the wind ensemble. Plenty of charm! Plenty of delight! Plenty of reeds!
The works on the program are:
Francois Devienne, Trio No. 5 in B-flat Major (for flute, clarinet & bassoon), Mikhail Glinka, Trio Pathétique in D Minor (for clarinet, bassoon & piano), Florent Schmitt, A Tour d’Anches (“Reeds in Turn”) (for oboe, clarinet, bassoon & piano), Clemence de Grandval, Trio de Salon, op. 8 (for oboe, bassoon & piano), Lukasš Hurnik, Fusion Music for Oboe, Clarinet, Bassoon & Piano, and Camille Saint-Saens, Caprice on Danish and Russian Airs (for flute, oboe, clarinet & piano).
Musicians appearing:
Parthena Owens, Flute, Lisa Harvey-Reed, Oboe, Chad Burrow, Clarinet, Rodney Ackmann, Bassoon , Ruirui Ouyang, Piano and Sallie Pollack on the Piano.
The performance will take place at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson). Individual concert admission is $20 per ticket. Children, students and active-duty military personnel are admitted free with ID. More information about this concert is available on Brightmusic’s website at http://www.brightmusic.org.