Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis.
But a new discovery from Oklahoma Medical Research Foundation scientist Rheal Towner, Ph.D., offers new hope in fighting this deadly cancer, which claimed the lives of Sens. John McCain and Ted Kennedy.
In pre-clinical experiments at OMRF, Towner discovered that a protein called ELTD1 is present in the most aggressive glioblastoma tumors. Towner then tested how the tumors would react to an antibody known to counteract the effects of ELTD1.
He found that the compound slowed the process of angiogenesis, the growth of new blood vessels, which is key to tumors’ ability to spread and kill.
“This drug seems just as promising, if not better than, what is currently considered the standard of care,” said Towner. “Few therapies exist for treating glioblastoma, but this could provide a step in the right direction.”
If proven effective in further trials, said Towner, “This could provide overall treatment with fewer side effects and better results than we see in current drugs.”
The new findings were published in the journal NeuroOncology.
Towner will continue to look for ways to use the new treatment in combination with other drugs to boost their effectiveness and better target tumors.
“One problem with drug treatments for tumors is that it’s hard to get the drug to the tumor site,” he said. “If we can regulate that process with targeting ELTD1, we might be able to use it to deliver other drugs directly to the tumor and, hopefully, eliminate it.”
If researchers succeed with this tumor-targeting method, Towner said they will begin testing it on other tumors associated with breast, pancreatic or other cancers.
Funding for this research was provided by National Institute of General Medical Sciences, grant number 5P20GM103636-02, and Institutional Development Award (IDeA) from the NIGMS, grant number 5P20GM103639. The NIGMS is part of the National Institutes of Health.

Photography and Text by Terry “Travels with Terry” Zinn [email protected]

Most people may only think of Mount Rushmore when they think about South Dakota. While it is not to be missed there are other attractions which need to be recognized.
The entire city of Deadwood is a national historic landmark. In Deadwood
you can ponder the truth at the foot of Wild Bill’s grave in Mount Moriah cemetery (along with Calamity Jane’s), tour Adams Museum and House, pan for gold at the Broken Boot Mine, choose from various guided tours, or take a self-guided walking tour into the past that puts the Wild West into perspective. You may even run into an incarnation of Wild Bill himself, either at the number 10 saloon or on horseback inspecting main street.
And there’s plenty of casinos for your gaming pleasure along with some fine eateries. One such is Kevin Costner’s Diamond Lil’s, where I had a pleasant Martini during sunset over main street. Costner’s memorabilia and costumes from his films are on display throughout the dining room, and if that was not enough finery, the top floor hosts a fine dining restaurant complete with piano and beveled glass décor.
Deadwood, South Dakota, is full of surprises such as Costner’s founded and funded Museum of the Tatanka (Buffalo) Museum right outside of town. Even with expert Lakota interpreters, displays of costumes worn in “Dances With Wolves”, and historic explanatory panels, the best part of Tatanka is the monumental 17 part sculpture of an Indian hunt near a buffalo jump. With wafts of movie theme music and the rustling of Dakota grass, this hill top venue is the pride of South Dakota, itself. Hats off and congratulations to Kevin Costner for giving back to America with the preservation and inspiration found at Tatanka: Story of the Bison interpretive Center and Sculpture. (For more information you may visit http://www.storyofthebison.com.
Up to 60 million Bison once roamed the Great Plains of North America. By the close of the 19th century, it was estimated that less than 1,000 bison survived.
This is their story… “I believe today that this place is bigger than the dream I had for it. What it means to anyone that comes here will be up to them. Tatanka was not designed as the white man’s version of the Native American. Rather it stands as a centerpiece for two cultures, one whose very lives depended on the buffalo and one who saw it as a means to an end. It recognizes and accepts that this is our mutual history. It can also represent the chance to move forward.” Kevin Costner, Attraction Founder/Owner
The badlands is another South Dakota wonder. (www.nps.gov/badl/index.htm) Roaming among the many outcroppings of natural time sculptured stone you are transported to another world. Containing the world’s richest Oligocene epoch fossil beds, dating 37-28 million years old, the evolutionary stories of mammals such as the horse and rhinoceros arise from the 244,000 acres of sharply eroded buttes, pinnacles, and spires.
Hill City calls itself the Heart of the Black Hills. The history of Hill city reaches back into Pennington County’s oldest archives. In 1876, it was the first settlement established in conjunction with the initial discovery of Black Hills gold in French Creek, 13 miles south of where Hill City sits today. Miners came from far and wide to prospect in and around this small mountain town, now referred to as “The Heart of the Hills.” Although the first settlement in the count, it was the second community to develop in the greater Black Hills area, springing up shortly after the town of Custer.
In addition to livening up the local scene in the dark of winter, Open Stage Concerts gives new talent and seasoned acts alike a supportive place to hone their craft. It also helps local promoters find and hire performers for summer shows and festivals. Local and regional singer/songwriters and poets are regulars, but storytellers, dancers, jugglers, and joke tellers are welcome too. The audience’s free-will donations help support their scholarship program and art education grants for local kids.
Open Stage concerts at the High Country Guest Ranch will be held February 9 and 23, and March 9 and 23, with doors open at 5:15 pm with the buffet starting at 5:30 pm.
Other Hill City attractions are the Museum at Black Hills Institute and the Black Hills Institute of geological Research and the South Dakota State Railroad Museum which might quench your curiosity.
While on your way to other South Dakota sights you may wish to explore Deadwood and Hill City.

Mr. Terry Zinn – Travel Editor
Past President: International Food Wine and Travel Writers Association
http://realtraveladventures.com/author/zinn

The stabbing pains in David Key’s armpits awoke him from sleep one night in 2006. “It was excruciating,” said Key, 53, who lives in Oil Center, about 10 miles northeast of Ada.
He cycled through hospitals and clinics, his condition worsening. He developed uncontrollable tremors and neurological problems and gave up his business. After a pair of strokes, he was forced to go on disability. Years passed, yet still he had no answers.
Finally, one physician thought he recognized Key’s condition. A subsequent biopsy of lymph nodes proved the hunch: sarcoidosis, a rare disease that causes lumps of immune cells – known as granulomas – to form in organs throughout the body.
“Unless patients’ first symptoms are in the lungs, they’re usually misdiagnosed,” said Courtney Montgomery, Ph.D., who studies the disease in her lab at the Oklahoma Medical Research Foundation.
Scientists know little about what triggers sarcoidosis. It seems to start in the immune system, eliciting rampant inflammation. The tumor-like lumps can appear in the eyes, liver, heart, skin and brain and, most often, in the lungs.
The disease can strike anyone, but it disproportionately affects African Americans. And, said Montgomery, it can be fatal.
“The most common causes of death are cardiac conditions,” she said. Heart complications claimed the disease’s two most famous victims – NFL Hall of Famer Reggie White and comedian Bernie Mac – at the ages of 43 and 50, respectively.
For Key, doctors have largely managed to control his symptoms through steroids and long list of other medications for the tremors, pain, depression and neurological issues. Still, he continues to experience near-constant pain in his chest. “Sometimes, I can swear I’m having a heart attack,” he said.
Last year, in an effort to help Montgomery and her OMRF scientific team better understand the disease, Key traveled to Oklahoma City to participate in a research study of sarcoidosis at the foundation. After filling out questionnaires detailing his disease and medication history, he donated blood for the researchers to analyze.
“By studying what’s going on at a genetic level in patients with active disease, we hope to identify environmental triggers that initiate sarcoidosis,” Montgomery said. Ultimately, that work might point scientists to an effective treatment.
Key understands that volunteering in OMRF’s research study likely won’t help directly. Still, he said, “If it can help somebody down the road, it’s worth it.”
For more information about sarcoidosis or to participate in research studies of the disease at the Oklahoma Medical Research Foundation, call (405) 271-2504 or email [email protected].

As new state leaders are sworn in today, John D. Doak reflects on his eight years as Oklahoma’s insurance commissioner. Doak was elected the state’s 12th insurance commissioner in 2010 and was re-elected for a second term in 2014.
“I’m honored that Oklahomans chose to elect me to represent them, both in terms of insurance company solvency and ensuring fair claims handling,” Doak said. “I’ve been privileged to witness the courage and resilience of Oklahomans in the face of difficult natural disasters. It’s also been a pleasure to work with our state Legislature and governor and to travel to every one of Oklahoma’s 77 counties, meeting and working with the people who live there.”
During his tenure, Doak has tirelessly worked to raise awareness of the Oklahoma Insurance Department (OID) and how it can help Oklahomans. He started a field representative program to reach every corner of the state. He also made it a mission to have boots on the ground as soon as possible after a disaster. Many times Doak himself would visit with storm victims to reassure them that his office was there to help, if needed.
Another issue Doak worked on during his time in office was lowering the rate of uninsured motorists. Oklahoma has one of the highest rates in the country. Just a few months ago, the OID announced it would host the Auto Insurance Verification System which allows law enforcement to verify a driver has insurance in real time.
“One of my proudest accomplishments is that, as I leave the OID, it is now being recognized as a global leader in insurance regulatory issues,” Doak said.
Doak’s recognition that government must be ready to accept new and innovative ideas and products has helped frame that thinking. His belief that the OID should not only to protect consumers but allow the free market process to bring new quality products to consumers is recognized by many leaders worldwide.
More of Doak’s accomplishments include:
*Recovering $27,675,828 for Oklahomans since 2011
*The passage of House Bill 2308 which allows the OID to construct and own an office building
*OID employees earning more than 160 professional designations
*Co-hosting the National Tornado Summit since 2011
*The passage of the Insurance Business Transfer law
*Developing an earthquake education requirement for insurance professionals
*Testifying before a U.S. Senate sub-committee about insurance fraud
*Helping launch the University of Tulsa Cyber District
“I wish the best to the new leaders of our state, Gov. Kevin Stitt, Lt. Gov. Matt Pinnell and Insurance Commissioner Glen Mulready,” Doak said. “Commissioner Mulready has already proven that he is a dedicated public servant with expertise in the insurance industry, and he will continue that tradition in this new role.”

Brightmusic Chamber Ensemble presents fine classical music in an intimate, family-friendly setting. All concerts will take place at 7:30 pm on Tuesday evenings at the beautiful and historic St. Paul’s Cathedral in downtown Oklahoma City at 127 NW 7th Street (at Robinson). Bright Music website, www.brightmusic.org, contains more detailed information about this concert, including the musicians who will be appearing. Season passes are available online, and individual tickets are available at the door for $20. Admission is free for children and students with student ID and for active-duty military service personnel with ID.
“Reeds-A-Plenty”
Experience the Richness
Tuesday, March 19, 2019, 7:30 pm at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson).
Experience the exquisite richness of woodwinds as the Brightmusic Chamber Ensemble presents a diverse sampling of 18th- through 20th-century works for reeds in its fourth concert of the 2018-19 season Tuesday evening, March 19, 2019. On the program are worthy works by Saint-Saëns and Glinka, as well as three of the worthiest French composers and a Czech you’ve probably never heard of. This is a rare opportunity to hear these delightful but less frequently performed works, some by composers who are best known for their compositions for the wind ensemble. Plenty of charm! Plenty of delight! Plenty of reeds!
The works on the program are:
Francois Devienne, Trio No. 5 in B-flat Major (for flute, clarinet & bassoon), Mikhail Glinka, Trio Pathétique in D Minor (for clarinet, bassoon & piano), Florent Schmitt, A Tour d’Anches (“Reeds in Turn”) (for oboe, clarinet, bassoon & piano), Clemence de Grandval, Trio de Salon, op. 8 (for oboe, bassoon & piano), Lukasš Hurnik, Fusion Music for Oboe, Clarinet, Bassoon & Piano, and Camille Saint-Saens, Caprice on Danish and Russian Airs (for flute, oboe, clarinet & piano).
Musicians appearing:
Parthena Owens, Flute, Lisa Harvey-Reed, Oboe, Chad Burrow, Clarinet, Rodney Ackmann, Bassoon , Ruirui Ouyang, Piano and Sallie Pollack on the Piano.
The performance will take place at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson). Individual concert admission is $20 per ticket. Children, students and active-duty military personnel are admitted free with ID. More information about this concert is available on Brightmusic’s website at http://www.brightmusic.org.

The Oklahoma History Center is honored to present Colonial Williamsburg’s Katharine Pittman in a portrayal of America’s “Lady Washington,” Martha Dandridge Custis Washington. The performance will be Thursday, February 7, from 7 to 8:30 p.m. and will take place in the Chesapeake Event Center. Admission costs are $10 for Oklahoma Historical Society members and $20 for nonmembers. There is no reserved seating, so early arrival is recommended. Tickets may be reserved by calling 405-522-0765. The Oklahoma History Center is located at 800 Nazih Zuhdi Drive in Oklahoma City.
Katharine Pittman has been an actor/interpreter for the Colonial Williamsburg Foundation for six years. She is a graduate of Wake Forest University and holds degrees in theater and history, and performed for many years around the country in musicals and operas. However, history was always her passion and, when given the opportunity, Pittman developed the Martha Washington portrayal and became one of the Nation Builders for Colonial Williamsburg.
While in Oklahoma, Pittman will make an appearance at the annual Colonial Day event at the Oklahoma State Capitol and Revolutionary Day in Tulsa.

What brings you joy in your life? Salvation Army Central Oklahoma Area Command

What really brings me joy is when my three boys have success in their personal life. Rick Dimit

The fact every day I can come here and have an opportunity to be Jesus’ hands extended. Dee Watts

Staying active … and playing pinball. Hugh Osborn

Seeing my friends every day and having my family close and working here brings me joy. Deanna Waltens

A chocolate Labrador Retriever named Penney and a passion for old maps led to a unique business opportunity.
“I am nearing retirement and decided if wanted to retire to the country where Penney would have a place to run, I would need to have a small business to make ends meet,” said Mike Howard, owner of Penney’s Territorial Maps.
After collecting old maps for many years, Howard began copying them and hanging them up at work and in his home. One thing led to another, and before long people were requesting them.
“We have about 30 shops in northeast Oklahoma who stock and sell the maps,” Howard said. “I have really been surprised at how well the maps have been received… The business is expanding to other states, and I now have dealers in Texas, Arkansas, Missouri and Kansas. I should be in New Mexico and Colorado by the end of 2019.”
Howard reproduces the old maps that are artificially aged and then sets them in rustic wood frames. Howard said he loves the reaction his customers have to his maps.
“I love hearing all the stories about their family’s history, looking for long lost towns, or pointing out where their land run claim was,” he said. “I have learned so much history about Oklahoma just talking to customers about the maps. I feel customers love the maps because it gives them a link to the past.”
Established in November 2016, Penney’s Territorial Maps joined the Made in Oklahoma Program this year. To learn more about the business, visit www.madeinoklahoma.net/products/penneys-territorial-maps/ or find them on Facebook.

by Bobby Anderson, Staff Writer

A new chapter is unfolding in the Tealridge retirement community history.
Oklahoma Christian University recently sold its Tealridge retirement community located at 2100 NE 140th Street in Edmond to a local group with big plans for this well-known senior living community on the university campus.
The new group owns and manages the Tealridge Assisted Living & Memory Care Community in Edmond as well as the University Village Retirement Community in Tulsa among other communities.
However, leadership is based locally in Edmond.
“With the addition of the Tealridge independent living community, we are now able to offer our residents a full care campus with housing options ranging from independent living apartments to assisted living and even memory care services – all in one location,” said Jon Paden, who leads the new group.
The sale took almost two years to complete given Oklahoma Christian’s desire to find the right buyer and ensure the community continued to be managed and owned by a group with integrity as well as shared values and beliefs.
The new owners are already starting to reinvest in the community with over $1 million funded for building improvements which will include updating all resident apartments, dining and social areas.
“We are excited to build on the great Tealridge reputation for quality in the Edmond community and we are blessed to be able to invest the money and resources needed to really create a special, yet affordable retirement option.” added Paden.
Daily operations will be managed by Melissa Mahaffey the new Executive Director at Tealridge Retirement Community.
While she has extensive senior living management experience, Mahaffey credits her success from a genuine passion for improving the lives of her senior residents.
She also serves on the Oklahoma Assisted Living Federation.
“I am so excited to be a part of the next chapter at Tealridge.” shared Mahaffey. “We have the resources and vision to really create a place that builds on Tealridge’s great reputation while updating things to be on par with the best rental communities in Edmond.”
In addition to the great residents that already call Tealridge home, Mahaffey is building a team focused on placing a strong emphasis on customer service, hospitality and convenience for retirees regardless of what phase of life they are in, Paden added.
To find out more about Tealridge you can go online at tealridge.com.