INTEGRIS is joining other hospitals and health centers around the country in a national effort to produce a stable supply of generic drugs. The venture is designed to address the growing frustration caused by persistent shortages of simple yet vital medications.
Utah-based not-for-profit generic-drug company Civica Rx is spearheading the initiative. “Drug shortages have become a national crisis, with patient treatments and surgeries canceled, delayed or suboptimal,” says Martin VanTrieste, chief executive officer of Civica Rx. “We thank these organizations for joining us to make essential generic medicines accessible and affordable in hospitals across the country.”
The benefit of the Civica Rx initiative is expected to be two-fold. Hospitals will not only have access to generic drugs that are frequently in short supply, but they will also be able to purchase those medications at a reduced cost. A savings that can then be passed along to patients.
“We are excited to be a partnering member in this venture,” says Tommy, Ibrahim, M.D., chief physician executive at INTEGRIS. “We enjoy a proud tradition of being a leading-edge health care provider known for a pioneering spirit that has paved the way for many medical firsts and technological advancements. We believe this initiative is another example of that. It is an innovative approach to providing quality, accessible, more affordable medicine to the citizens of Oklahoma.”
Civica Rx plans to bring 14 hospital-administered generic drugs to market in 2019. The overall vision is to become a model generic drug company that provides high-quality Food and Drug Administration-approved products at affordable prices.

Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis.
But a new discovery from Oklahoma Medical Research Foundation scientist Rheal Towner, Ph.D., offers new hope in fighting this deadly cancer, which claimed the lives of Sens. John McCain and Ted Kennedy.
In pre-clinical experiments at OMRF, Towner discovered that a protein called ELTD1 is present in the most aggressive glioblastoma tumors. Towner then tested how the tumors would react to an antibody known to counteract the effects of ELTD1.
He found that the compound slowed the process of angiogenesis, the growth of new blood vessels, which is key to tumors’ ability to spread and kill.
“This drug seems just as promising, if not better than, what is currently considered the standard of care,” said Towner. “Few therapies exist for treating glioblastoma, but this could provide a step in the right direction.”
If proven effective in further trials, said Towner, “This could provide overall treatment with fewer side effects and better results than we see in current drugs.”
The new findings were published in the journal NeuroOncology.
Towner will continue to look for ways to use the new treatment in combination with other drugs to boost their effectiveness and better target tumors.
“One problem with drug treatments for tumors is that it’s hard to get the drug to the tumor site,” he said. “If we can regulate that process with targeting ELTD1, we might be able to use it to deliver other drugs directly to the tumor and, hopefully, eliminate it.”
If researchers succeed with this tumor-targeting method, Towner said they will begin testing it on other tumors associated with breast, pancreatic or other cancers.
Funding for this research was provided by National Institute of General Medical Sciences, grant number 5P20GM103636-02, and Institutional Development Award (IDeA) from the NIGMS, grant number 5P20GM103639. The NIGMS is part of the National Institutes of Health.

A chocolate Labrador Retriever named Penney and a passion for old maps led to a unique business opportunity.
“I am nearing retirement and decided if wanted to retire to the country where Penney would have a place to run, I would need to have a small business to make ends meet,” said Mike Howard, owner of Penney’s Territorial Maps.
After collecting old maps for many years, Howard began copying them and hanging them up at work and in his home. One thing led to another, and before long people were requesting them.
“We have about 30 shops in northeast Oklahoma who stock and sell the maps,” Howard said. “I have really been surprised at how well the maps have been received… The business is expanding to other states, and I now have dealers in Texas, Arkansas, Missouri and Kansas. I should be in New Mexico and Colorado by the end of 2019.”
Howard reproduces the old maps that are artificially aged and then sets them in rustic wood frames. Howard said he loves the reaction his customers have to his maps.
“I love hearing all the stories about their family’s history, looking for long lost towns, or pointing out where their land run claim was,” he said. “I have learned so much history about Oklahoma just talking to customers about the maps. I feel customers love the maps because it gives them a link to the past.”
Established in November 2016, Penney’s Territorial Maps joined the Made in Oklahoma Program this year. To learn more about the business, visit www.madeinoklahoma.net/products/penneys-territorial-maps/ or find them on Facebook.

by Bobby Anderson, Staff Writer

Like many, Karyl James, MSN, BSN, RN, Mercy Hospital CNO watched the frequent headlines marking deadly shootings.
And the reports of violence inside health care showed no signs of slowing down.
But what happens if the two scenarios combined? It was a question James and others in the Mercy system really didn’t want to think about, but one they knew they had to answer.
“With all the public shootings going on our safety team in collaboration with nursing said we have to educate and do something about it,” James said recently.
Through planning, discussion and scenarios Code Roscoe was born.
The code is Mercy-wide, so all 45 hospitals in the system use it for any active shooter situation.
Each unit must have at least two identified safe places that can prevent a shooter’s access to people.
“It’s not just nursing it’s registration, it’s all of those individuals. The front door of the hospital is registration so they need a safe place,” James said.
Planning for the unknown is a constant battle. Knowing who might have a gun is another.
A former ER nurse, James is familiar with both.
“Unknown was just kind of second nature for me and personally, I’ve had a gun pointed at me as an ER nurse many years ago,” James said.
It was an eye-opener to say the least.
“Yeah, I’m going to die. It was frightening,” James said of what flashed through her mind all those years ago. “He was not in his right mind and pulled out the revolver. Luckily, I had a police officer right next to me and he grabbed the gun.”
“The worst we can do is say ‘Oh, that will never happen to me because it might.’”
James knows working without a plan would shortchange everyone. That’s why she’s invested in the planning, hoping it will never be put to use.
The first drill that was run pointed out several instances where locking mechanisms didn’t work the way they should have.
The second time the code was called it wasn’t a drill.
“I got that call on a Sunday afternoon and I just froze,” James said of the scenario where the hospital locked down after a suspect in a nearby neighborhood was seen with a gun. “My stomach just sank because there was no drill.”
Out of instinct the first thing James did was call the house supervisor. That wasn’t protocol.
“The first thing you do is turn your phone off and text only,” James said. “I was the administrator on call.”
The house supervisor did answer and whispered to James she and several others were huddled under a table in the nursing administration offices.
“There was no lock on that door so they had the table pushed against the door,” James said. “The larger space you could just walk in. We’ve since put a badge reader on that door.”
Officials also learned the emergency locking button that seals all doors in the emergency department did not work.
“You could literally walk up and push open our ER so we got that fixed,” James said. “It really kind of opened our eyes to a lot of the safety measures we thought we had but really didn’t.”
Mercy has had Code Roscoe in place for nearly three years now. It’s evolved along the way.
“The reason I feel good about it is because the co-workers feel good about it,” James beamed. “After that actual event I went to the hospital after it was all said and done. It was a grueling 45 minutes because that was about how long it took for police to subdue the individual shooting in the neighborhood. I rounded on staff.”
“They knew exactly what to do. They knew where their safe spots were and the locks worked. They felt safer. For me, that’s a win.”
Planning for the unexpected is challenging to say the least.
“There’s always something new and I think you have to be flexible to understand you don’t have everything figured out and you never will,” she said.
“I get shocked every day with something new. Being open to accepting that and training as much as you possibly can for those bigger events – coworkers will figure out what they need to do and what is right to do for their patients and their safety.”

by Major Lesley Norman, Risk Reduction Officer, Oklahoma City Fire Department

At the beginning of the year, we set goals to make positive improvements in your lives. Most people never consider improving safety around their residents. The Oklahoma City Fire Department (OKCFD) has a few safety suggestions for 2019. Ensure the following safety recommendations are completed to provide a safer year for you and your family at home.
Smoke alarms should be installed inside each bedroom/sleeping area and one outside those areas. Smoke alarms should also be installed on every level of the home including basements. The Oklahoma City Fire Department “Project Life” smoke alarm program allows Firefighters to install smoke alarms at no charge for qualifying residents of Oklahoma City. Contact 405-316-2337, www.smokealarmsokc.com or www.Gratisalarmasokc.com to request smoke alarms. Residents outside of Oklahoma City can contact your local fire department or Red Cross. The hearing impaired can contact the Oklahoma Assistive Technology Foundation (OkAT), 888-885-5588 or email [email protected]. OkAT will install smoke alarms with strobe lights and bed shaker for qualifying Oklahoma residents. Apply at www.okabletech.okstate.edu.
Carbon Monoxide alarms should be installed in a central location outside each sleeping area and on every level of the home according to the National Fire Protection Association (NFPA). Carbon Monoxide (CO) is an odorless, colorless, poisonous gas created from incomplete combustion of natural gas, propane, methane or gasoline. Running vehicles and generators also produce CO. Make sure gas appliances are professionally serviced every year to avoid possible CO leaks inside your home.
Fire extinguishers should be located in a kitchen, garage or both, ready to extinguish small fires. If there are smokers in the home, consider additional locations. Small “ABC” extinguishers can be purchased from the local department store and are disposable. Review the manufacturers’ recommendation for a disposal date. Always call 911 or have someone call 911 before extinguishing a fire. When using the extinguisher apply the PASS method for extinguishment, stand six to eight feet from the fire. P – pull the pin, A – aim low at the base of the fire, S – squeeze the lever slowly, S – sweep from side to side. An OKCFD training video is available at https://www.youtube.com/watch?v=w_ZYolzwMX4 or follow instructions provided with the extinguisher.
Fire drills should be practiced monthly while testing your smoke alarm. The OKCFD has a program called “EDITH,” Exit Drills In The Home. The EDITH program’s purpose is to inspire residents to develop an exit plan for their home. The exit plan should include two ways out of every bedroom, a meeting place outside the home, and practicing the fire drill. Practice your exit plan around your mobility and the plan should be shared with everyone sleeping in your home.
Fall prevention measures should include installing grab bars inside your home if you or other family members have a fall risk. Suggested location for grab bars is near toilets and bathtubs. Make sure you have a clear path to the restroom from your sleeping area. Use your walking aid or lift chair on those days you feel weaker than normal. Speak with your physician if your strength starts to fade. Begin this year making fire and fall safety improvements a priority in your life.
* According to the National Fire Protection Association (NFPA), “3 out of 5 fire deaths happen in homes with no smoke alarms or the alarms are not working.”
Additional fire safety information is available at www.nfpa.org/Public-Education.

The stabbing pains in David Key’s armpits awoke him from sleep one night in 2006. “It was excruciating,” said Key, 53, who lives in Oil Center, about 10 miles northeast of Ada.
He cycled through hospitals and clinics, his condition worsening. He developed uncontrollable tremors and neurological problems and gave up his business. After a pair of strokes, he was forced to go on disability. Years passed, yet still he had no answers.
Finally, one physician thought he recognized Key’s condition. A subsequent biopsy of lymph nodes proved the hunch: sarcoidosis, a rare disease that causes lumps of immune cells – known as granulomas – to form in organs throughout the body.
“Unless patients’ first symptoms are in the lungs, they’re usually misdiagnosed,” said Courtney Montgomery, Ph.D., who studies the disease in her lab at the Oklahoma Medical Research Foundation.
Scientists know little about what triggers sarcoidosis. It seems to start in the immune system, eliciting rampant inflammation. The tumor-like lumps can appear in the eyes, liver, heart, skin and brain and, most often, in the lungs.
The disease can strike anyone, but it disproportionately affects African Americans. And, said Montgomery, it can be fatal.
“The most common causes of death are cardiac conditions,” she said. Heart complications claimed the disease’s two most famous victims – NFL Hall of Famer Reggie White and comedian Bernie Mac – at the ages of 43 and 50, respectively.
For Key, doctors have largely managed to control his symptoms through steroids and long list of other medications for the tremors, pain, depression and neurological issues. Still, he continues to experience near-constant pain in his chest. “Sometimes, I can swear I’m having a heart attack,” he said.
Last year, in an effort to help Montgomery and her OMRF scientific team better understand the disease, Key traveled to Oklahoma City to participate in a research study of sarcoidosis at the foundation. After filling out questionnaires detailing his disease and medication history, he donated blood for the researchers to analyze.
“By studying what’s going on at a genetic level in patients with active disease, we hope to identify environmental triggers that initiate sarcoidosis,” Montgomery said. Ultimately, that work might point scientists to an effective treatment.
Key understands that volunteering in OMRF’s research study likely won’t help directly. Still, he said, “If it can help somebody down the road, it’s worth it.”
For more information about sarcoidosis or to participate in research studies of the disease at the Oklahoma Medical Research Foundation, call (405) 271-2504 or email [email protected].

by Bryan Painter

Muskogee – A lot of people say they are thankful for what time has taught them. However, Kelly Wiedel, who ranches with husband Bart in eastern Oklahoma, has a lifetime of experiences to back that up.
There are simple things she has learned.
Take for instance haying.
“I’ll never forget the day when my father-in-law Jim Wiedel said I had tractor driving in my blood because I asked him if I could rake again,” Kelly Wiedel said.
She also won’t forget what she learned one day when she was out haying.
“When raking hay with a tractor without a cab, stay away from bumble bees,” she said.
Wiedel has painted countless feet of pipe fence and gateways.
“From that I have learned to always paint with the wind at my back,” she said.
There are also things she’s learned that weren’t so simple, such as the first time her husband was ever involved in a vehicle accident. She was a passenger.
“It caused me to get vertigo and after time with it not going away and many different tests and scans of my head,” she said, “we found out that I had a brain aneurism and had to have brain surgery. So the wreck was a blessing because it saved my life.”
Perhaps it was all those experiences and more that led her to place a sign in their dining room that reads, “It may not be the easy way, but it’s the Cowboy Way.”
On a Sunday morning
Kelly was only 6 years old when she met this lanky boy named Bart at church on a Sunday in the early 1970s. Her family had just moved to the area and as it turned out, she grew up living roughly 10 miles from his family’s cow/calf and haying operation.
Kelly and Bart married in 1984 and started out with a small cow/calf operation near Muskogee. Three years later they became partners with his parents and together the families had 400 momma cows.
In between then and now, they have purchased more land and cattle. They have taken on the management of another 1,000-acre ranch.
Beverly Delmedico has known Kelly and Bart for several years.
“I don’t know of a couple that is closer together than Bart and Kelly,” she said. “They do absolutely everything together. They are just something else. I love Bart and Kelly both.”
Very proud of their family
Wiedel has another sign hanging on the wall, “Home is where the herd is.”
While they are proud of their ranch, they are extremely proud of their family. Others have recognized the Wiedels as well.
Kelly and Bart’s family received the Oklahoma Farm Bureau Women’s Leadership Committee’s District Six Farm and Ranch Family Recognition during the organization’s 77th annual meeting on Nov. 17.
They have three children, James Robert Wiedel, Jared Jay Wiedel and Lacy Miller, along with six grandchildren.
So, Kelly Wiedel says this about agriculture.
“It has given me a life to work beside my husband and raise our children in a way of life that has made them want to continue to live their lives in agriculture,” she said. “Our two sons have cattle of their own and work with us in the hay field. Our daughter and her husband have their own cattle operation about 45 miles away. We hope that our children and grandchildren have learned that hard work will make them better people.”
There is that word again, “learned.”
Life on an agricultural operation provides its own forms of continuing education.
There are the enjoyable lessons.
“I am most happy on the ranch when it is spring time and all the baby calves are running around,” she said.
Then, there are the challenging lessons.
“We went through a bad drought and had to bale cornstalks to provide hay for our cattle, because we sold more hay than our fields made because of the drought,” she said.
A key part of that comment is, “We went through…” They didn’t stop, they didn’t turn back. They put on their work gloves and they “went through.”
So how does Wiedel summarize the lessons learned so far in life?
Kelly Wiedel said, “It takes a person who is willing to put in a lot of time and hard work to make a ranch successful.”

Brightmusic Chamber Ensemble presents fine classical music in an intimate, family-friendly setting. All concerts will take place at 7:30 pm on Tuesday evenings at the beautiful and historic St. Paul’s Cathedral in downtown Oklahoma City at 127 NW 7th Street (at Robinson). Bright Music website, www.brightmusic.org, contains more detailed information about this concert, including the musicians who will be appearing. Season passes are available online, and individual tickets are available at the door for $20. Admission is free for children and students with student ID and for active-duty military service personnel with ID.
“Reeds-A-Plenty”
Experience the Richness
Tuesday, March 19, 2019, 7:30 pm at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson).
Experience the exquisite richness of woodwinds as the Brightmusic Chamber Ensemble presents a diverse sampling of 18th- through 20th-century works for reeds in its fourth concert of the 2018-19 season Tuesday evening, March 19, 2019. On the program are worthy works by Saint-Saëns and Glinka, as well as three of the worthiest French composers and a Czech you’ve probably never heard of. This is a rare opportunity to hear these delightful but less frequently performed works, some by composers who are best known for their compositions for the wind ensemble. Plenty of charm! Plenty of delight! Plenty of reeds!
The works on the program are:
Francois Devienne, Trio No. 5 in B-flat Major (for flute, clarinet & bassoon), Mikhail Glinka, Trio Pathétique in D Minor (for clarinet, bassoon & piano), Florent Schmitt, A Tour d’Anches (“Reeds in Turn”) (for oboe, clarinet, bassoon & piano), Clemence de Grandval, Trio de Salon, op. 8 (for oboe, bassoon & piano), Lukasš Hurnik, Fusion Music for Oboe, Clarinet, Bassoon & Piano, and Camille Saint-Saens, Caprice on Danish and Russian Airs (for flute, oboe, clarinet & piano).
Musicians appearing:
Parthena Owens, Flute, Lisa Harvey-Reed, Oboe, Chad Burrow, Clarinet, Rodney Ackmann, Bassoon , Ruirui Ouyang, Piano and Sallie Pollack on the Piano.
The performance will take place at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson). Individual concert admission is $20 per ticket. Children, students and active-duty military personnel are admitted free with ID. More information about this concert is available on Brightmusic’s website at http://www.brightmusic.org.