Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis.
But a new discovery from Oklahoma Medical Research Foundation scientist Rheal Towner, Ph.D., offers new hope in fighting this deadly cancer, which claimed the lives of Sens. John McCain and Ted Kennedy.
In pre-clinical experiments at OMRF, Towner discovered that a protein called ELTD1 is present in the most aggressive glioblastoma tumors. Towner then tested how the tumors would react to an antibody known to counteract the effects of ELTD1.
He found that the compound slowed the process of angiogenesis, the growth of new blood vessels, which is key to tumors’ ability to spread and kill.
“This drug seems just as promising, if not better than, what is currently considered the standard of care,” said Towner. “Few therapies exist for treating glioblastoma, but this could provide a step in the right direction.”
If proven effective in further trials, said Towner, “This could provide overall treatment with fewer side effects and better results than we see in current drugs.”
The new findings were published in the journal NeuroOncology.
Towner will continue to look for ways to use the new treatment in combination with other drugs to boost their effectiveness and better target tumors.
“One problem with drug treatments for tumors is that it’s hard to get the drug to the tumor site,” he said. “If we can regulate that process with targeting ELTD1, we might be able to use it to deliver other drugs directly to the tumor and, hopefully, eliminate it.”
If researchers succeed with this tumor-targeting method, Towner said they will begin testing it on other tumors associated with breast, pancreatic or other cancers.
Funding for this research was provided by National Institute of General Medical Sciences, grant number 5P20GM103636-02, and Institutional Development Award (IDeA) from the NIGMS, grant number 5P20GM103639. The NIGMS is part of the National Institutes of Health.

Brightmusic Chamber Ensemble presents fine classical music in an intimate, family-friendly setting. All concerts will take place at 7:30 pm on Tuesday evenings at the beautiful and historic St. Paul’s Cathedral in downtown Oklahoma City at 127 NW 7th Street (at Robinson). Bright Music website, www.brightmusic.org, contains more detailed information about this concert, including the musicians who will be appearing. Season passes are available online, and individual tickets are available at the door for $20. Admission is free for children and students with student ID and for active-duty military service personnel with ID.
“Reeds-A-Plenty”
Experience the Richness
Tuesday, March 19, 2019, 7:30 pm at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson).
Experience the exquisite richness of woodwinds as the Brightmusic Chamber Ensemble presents a diverse sampling of 18th- through 20th-century works for reeds in its fourth concert of the 2018-19 season Tuesday evening, March 19, 2019. On the program are worthy works by Saint-Saëns and Glinka, as well as three of the worthiest French composers and a Czech you’ve probably never heard of. This is a rare opportunity to hear these delightful but less frequently performed works, some by composers who are best known for their compositions for the wind ensemble. Plenty of charm! Plenty of delight! Plenty of reeds!
The works on the program are:
Francois Devienne, Trio No. 5 in B-flat Major (for flute, clarinet & bassoon), Mikhail Glinka, Trio Pathétique in D Minor (for clarinet, bassoon & piano), Florent Schmitt, A Tour d’Anches (“Reeds in Turn”) (for oboe, clarinet, bassoon & piano), Clemence de Grandval, Trio de Salon, op. 8 (for oboe, bassoon & piano), Lukasš Hurnik, Fusion Music for Oboe, Clarinet, Bassoon & Piano, and Camille Saint-Saens, Caprice on Danish and Russian Airs (for flute, oboe, clarinet & piano).
Musicians appearing:
Parthena Owens, Flute, Lisa Harvey-Reed, Oboe, Chad Burrow, Clarinet, Rodney Ackmann, Bassoon , Ruirui Ouyang, Piano and Sallie Pollack on the Piano.
The performance will take place at St. Paul’s Cathedral, 127 NW 7th Street (at Robinson). Individual concert admission is $20 per ticket. Children, students and active-duty military personnel are admitted free with ID. More information about this concert is available on Brightmusic’s website at http://www.brightmusic.org.

A chocolate Labrador Retriever named Penney and a passion for old maps led to a unique business opportunity.
“I am nearing retirement and decided if wanted to retire to the country where Penney would have a place to run, I would need to have a small business to make ends meet,” said Mike Howard, owner of Penney’s Territorial Maps.
After collecting old maps for many years, Howard began copying them and hanging them up at work and in his home. One thing led to another, and before long people were requesting them.
“We have about 30 shops in northeast Oklahoma who stock and sell the maps,” Howard said. “I have really been surprised at how well the maps have been received… The business is expanding to other states, and I now have dealers in Texas, Arkansas, Missouri and Kansas. I should be in New Mexico and Colorado by the end of 2019.”
Howard reproduces the old maps that are artificially aged and then sets them in rustic wood frames. Howard said he loves the reaction his customers have to his maps.
“I love hearing all the stories about their family’s history, looking for long lost towns, or pointing out where their land run claim was,” he said. “I have learned so much history about Oklahoma just talking to customers about the maps. I feel customers love the maps because it gives them a link to the past.”
Established in November 2016, Penney’s Territorial Maps joined the Made in Oklahoma Program this year. To learn more about the business, visit www.madeinoklahoma.net/products/penneys-territorial-maps/ or find them on Facebook.

by Bryan Painter

Muskogee – A lot of people say they are thankful for what time has taught them. However, Kelly Wiedel, who ranches with husband Bart in eastern Oklahoma, has a lifetime of experiences to back that up.
There are simple things she has learned.
Take for instance haying.
“I’ll never forget the day when my father-in-law Jim Wiedel said I had tractor driving in my blood because I asked him if I could rake again,” Kelly Wiedel said.
She also won’t forget what she learned one day when she was out haying.
“When raking hay with a tractor without a cab, stay away from bumble bees,” she said.
Wiedel has painted countless feet of pipe fence and gateways.
“From that I have learned to always paint with the wind at my back,” she said.
There are also things she’s learned that weren’t so simple, such as the first time her husband was ever involved in a vehicle accident. She was a passenger.
“It caused me to get vertigo and after time with it not going away and many different tests and scans of my head,” she said, “we found out that I had a brain aneurism and had to have brain surgery. So the wreck was a blessing because it saved my life.”
Perhaps it was all those experiences and more that led her to place a sign in their dining room that reads, “It may not be the easy way, but it’s the Cowboy Way.”
On a Sunday morning
Kelly was only 6 years old when she met this lanky boy named Bart at church on a Sunday in the early 1970s. Her family had just moved to the area and as it turned out, she grew up living roughly 10 miles from his family’s cow/calf and haying operation.
Kelly and Bart married in 1984 and started out with a small cow/calf operation near Muskogee. Three years later they became partners with his parents and together the families had 400 momma cows.
In between then and now, they have purchased more land and cattle. They have taken on the management of another 1,000-acre ranch.
Beverly Delmedico has known Kelly and Bart for several years.
“I don’t know of a couple that is closer together than Bart and Kelly,” she said. “They do absolutely everything together. They are just something else. I love Bart and Kelly both.”
Very proud of their family
Wiedel has another sign hanging on the wall, “Home is where the herd is.”
While they are proud of their ranch, they are extremely proud of their family. Others have recognized the Wiedels as well.
Kelly and Bart’s family received the Oklahoma Farm Bureau Women’s Leadership Committee’s District Six Farm and Ranch Family Recognition during the organization’s 77th annual meeting on Nov. 17.
They have three children, James Robert Wiedel, Jared Jay Wiedel and Lacy Miller, along with six grandchildren.
So, Kelly Wiedel says this about agriculture.
“It has given me a life to work beside my husband and raise our children in a way of life that has made them want to continue to live their lives in agriculture,” she said. “Our two sons have cattle of their own and work with us in the hay field. Our daughter and her husband have their own cattle operation about 45 miles away. We hope that our children and grandchildren have learned that hard work will make them better people.”
There is that word again, “learned.”
Life on an agricultural operation provides its own forms of continuing education.
There are the enjoyable lessons.
“I am most happy on the ranch when it is spring time and all the baby calves are running around,” she said.
Then, there are the challenging lessons.
“We went through a bad drought and had to bale cornstalks to provide hay for our cattle, because we sold more hay than our fields made because of the drought,” she said.
A key part of that comment is, “We went through…” They didn’t stop, they didn’t turn back. They put on their work gloves and they “went through.”
So how does Wiedel summarize the lessons learned so far in life?
Kelly Wiedel said, “It takes a person who is willing to put in a lot of time and hard work to make a ranch successful.”

by Bobby Anderson, Staff Writer

On the darkest days, sometimes all it takes is a single ray of light to turn everything around.
For the last 20 years, Louise Colbaugh, 90, has shined in the Oklahoma City metro, volunteering at metro hospitals.
Colbaugh is closing in on three years volunteering at Community Hospital in south Oklahoma City but before that she gave 17 years at Hillcrest and eventually St. Anthony.
“I enjoyed it,” she said of her decades of unpaid service. “I don’t know. It’s just a way of life after awhile, you get up and go. You don’t sit at home and watch television or whatever.”
Colbaugh stayed home until almost 45, rearing a son and a daughter before heading out into the workforce.
Her son moved on to the paper products industry in Houston. Her daughter is close by in Moore and retired herself.
Her great granddaughter has already graduated college and is going on to pursue her degree as a physician’s assistant.
Attending graduation for her great granddaughter was a moment she’ll never forget.
“Wonderful and proud,” beamed Colbaugh, who also has two younger great grandchildren.
After raising kids and before volunteering she went back to school and studied accounting. She worked in the accounting department at Shepler’s western store.
As her husband’s health faltered, she decided she needed better insurance. She worked at Tinker Air Force Base as a civilian in the accounting department, eventually in the AWACs division.
Numbers were numbers, but only a lot more zeroes were at the end of those military budgets.
Colbaugh and her husband celebrated 51 years of marriage before he passed.
“It was bad,” she said of the end. “He had so many heart surgeries before he died. They tried to do surgery on him again and he never came out of it.”
For most who spend time with a loved one during an extended illness, the hospital would be the last place they would want to spend more time. Too many hours of fear and pain.
Colbaugh ran towards it.
“It’s just a way of life. It’s like another home to me,” Colbaugh said. “It gives you a purpose to get up in the morning. You know you’re going to meet people and you’re going to talk. I just like to do it.”
It’s an opportunity for Colbaugh to pour into others. She has stories to share. She’s felt the same feelings.
“It may be something like getting them a cup of coffee or a warm blanket,” Colbaugh explained. “I enjoy doing it and I enjoy talking to the people. It’s satisfying I can help people.”
“Like I say, it’s a way of life for me now.”
Colbaugh’s journey to Community Hospital began when St. Anthony closed its gift shop. A few of her fellow volunteers made the trip as well.
“Some people they’ll sit home and don’t do anything and then they wonder why they feel so bad,” Colbaugh said. “If they only knew how satisfying it was they would run for it really. That includes men and women. I work with both.”
“And there’s always somebody coming in and they see what you’re doing and they want to volunteer, too, but it’s getting farther and farther in between.”
Community Hospital has two campuses featuring a comprehensive range of medical services offering nursing care in a close-knit, compassionate community.
“You get paid. You get paid with gratitude and the thank-you’s you get,” Colbaugh said. “Men especially say ‘thank you for being a volunteer.’ That just makes me feel good.”
“And Roxy (Kostuck) our manager she is so good to all of us. She has Valentine’s parties and she gave me a 90th birthday party and it was wonderful.”
She immediately used the gift certificate she received to splurge on a cashmere sweater.
Colbaugh typically volunteers every Monday and Tuesday, coming in at 8 a.m. and working until 2 p.m.
She grabs the cart filled with complimentary items and goes room to room checking on patients and their families asking if they need anything.
From there she goes to the surgery waiting room.
“I go in and see what I can do for them,” she said. “And then I come back and Roxy always has something. I wrap a lot of gifts. They give away so much I can’t believe a hospital does that.”
As you might expect, Colbaugh is a big fan of volunteering her time. She’s quick to share her experience when others ask.
“I would tell them they would appreciate coming up here once they started,” Colbaugh said. “It would be good for them and they would get lots of exercise. I think they would love it.”

by Bobby Anderson, Staff Writer

A new chapter is unfolding in the Tealridge retirement community history.
Oklahoma Christian University recently sold its Tealridge retirement community located at 2100 NE 140th Street in Edmond to a local group with big plans for this well-known senior living community on the university campus.
The new group owns and manages the Tealridge Assisted Living & Memory Care Community in Edmond as well as the University Village Retirement Community in Tulsa among other communities.
However, leadership is based locally in Edmond.
“With the addition of the Tealridge independent living community, we are now able to offer our residents a full care campus with housing options ranging from independent living apartments to assisted living and even memory care services – all in one location,” said Jon Paden, who leads the new group.
The sale took almost two years to complete given Oklahoma Christian’s desire to find the right buyer and ensure the community continued to be managed and owned by a group with integrity as well as shared values and beliefs.
The new owners are already starting to reinvest in the community with over $1 million funded for building improvements which will include updating all resident apartments, dining and social areas.
“We are excited to build on the great Tealridge reputation for quality in the Edmond community and we are blessed to be able to invest the money and resources needed to really create a special, yet affordable retirement option.” added Paden.
Daily operations will be managed by Melissa Mahaffey the new Executive Director at Tealridge Retirement Community.
While she has extensive senior living management experience, Mahaffey credits her success from a genuine passion for improving the lives of her senior residents.
She also serves on the Oklahoma Assisted Living Federation.
“I am so excited to be a part of the next chapter at Tealridge.” shared Mahaffey. “We have the resources and vision to really create a place that builds on Tealridge’s great reputation while updating things to be on par with the best rental communities in Edmond.”
In addition to the great residents that already call Tealridge home, Mahaffey is building a team focused on placing a strong emphasis on customer service, hospitality and convenience for retirees regardless of what phase of life they are in, Paden added.
To find out more about Tealridge you can go online at tealridge.com.

As new state leaders are sworn in today, John D. Doak reflects on his eight years as Oklahoma’s insurance commissioner. Doak was elected the state’s 12th insurance commissioner in 2010 and was re-elected for a second term in 2014.
“I’m honored that Oklahomans chose to elect me to represent them, both in terms of insurance company solvency and ensuring fair claims handling,” Doak said. “I’ve been privileged to witness the courage and resilience of Oklahomans in the face of difficult natural disasters. It’s also been a pleasure to work with our state Legislature and governor and to travel to every one of Oklahoma’s 77 counties, meeting and working with the people who live there.”
During his tenure, Doak has tirelessly worked to raise awareness of the Oklahoma Insurance Department (OID) and how it can help Oklahomans. He started a field representative program to reach every corner of the state. He also made it a mission to have boots on the ground as soon as possible after a disaster. Many times Doak himself would visit with storm victims to reassure them that his office was there to help, if needed.
Another issue Doak worked on during his time in office was lowering the rate of uninsured motorists. Oklahoma has one of the highest rates in the country. Just a few months ago, the OID announced it would host the Auto Insurance Verification System which allows law enforcement to verify a driver has insurance in real time.
“One of my proudest accomplishments is that, as I leave the OID, it is now being recognized as a global leader in insurance regulatory issues,” Doak said.
Doak’s recognition that government must be ready to accept new and innovative ideas and products has helped frame that thinking. His belief that the OID should not only to protect consumers but allow the free market process to bring new quality products to consumers is recognized by many leaders worldwide.
More of Doak’s accomplishments include:
*Recovering $27,675,828 for Oklahomans since 2011
*The passage of House Bill 2308 which allows the OID to construct and own an office building
*OID employees earning more than 160 professional designations
*Co-hosting the National Tornado Summit since 2011
*The passage of the Insurance Business Transfer law
*Developing an earthquake education requirement for insurance professionals
*Testifying before a U.S. Senate sub-committee about insurance fraud
*Helping launch the University of Tulsa Cyber District
“I wish the best to the new leaders of our state, Gov. Kevin Stitt, Lt. Gov. Matt Pinnell and Insurance Commissioner Glen Mulready,” Doak said. “Commissioner Mulready has already proven that he is a dedicated public servant with expertise in the insurance industry, and he will continue that tradition in this new role.”

The Oklahoma History Center is honored to present Colonial Williamsburg’s Katharine Pittman in a portrayal of America’s “Lady Washington,” Martha Dandridge Custis Washington. The performance will be Thursday, February 7, from 7 to 8:30 p.m. and will take place in the Chesapeake Event Center. Admission costs are $10 for Oklahoma Historical Society members and $20 for nonmembers. There is no reserved seating, so early arrival is recommended. Tickets may be reserved by calling 405-522-0765. The Oklahoma History Center is located at 800 Nazih Zuhdi Drive in Oklahoma City.
Katharine Pittman has been an actor/interpreter for the Colonial Williamsburg Foundation for six years. She is a graduate of Wake Forest University and holds degrees in theater and history, and performed for many years around the country in musicals and operas. However, history was always her passion and, when given the opportunity, Pittman developed the Martha Washington portrayal and became one of the Nation Builders for Colonial Williamsburg.
While in Oklahoma, Pittman will make an appearance at the annual Colonial Day event at the Oklahoma State Capitol and Revolutionary Day in Tulsa.

WESTVILLE – A number of years ago, Terry and Pam Lamb began sharing a mustard recipe with friends and family. Now, they’ve created a business out of it.
“After being asked to bottle our lemon dill mustard so friends and family could share it with others, we decided to look into making it a business,” Terry Lamb said. “We had no experience in producing a food product. We looked to our local SCORE office for assistance. They suggested we market more than one product. We started playing with flavors and came up with over 10 we felt would be marketable and decided to start marketing three.”
Partnering with Pam’s mother, Vienna Willard, the Lambs converted their shop into a commercial kitchen. After approval from the Oklahoma State Department of Health, Tajour Specialty Products was ready for production.
“We currently manufacture three flavors of mustard,” Terry Lamb said. “Our flavors include lemon dill mustard, rosemary garlic mustard and cranberry orange mustard. We have a number of other flavors developed with the intention of introducing more flavors as our company grows.”
The Lambs chose to incorporate a Hand Up Program, in which they donate 2 percent of every sale to go into an account to help people in their community build local businesses and fight food insecurity.
“We also try to make our products versatile,” he said. “Our mustards can be spread on a cracker with cheese or used on a sandwich. They can also be used as an ingredient in recipes. Our favorite is to make a dressing out of our cranberry orange mustard by mixing it with equal amounts of honey and using it on a salad or as dip. Making deviled eggs using any of our mustards runs a close second.”
Lamb said the goal is to create flavorful, healthy products without added sugar, salt or fat. Tajour Specialty Products was established in November 2017 and started sales in December 2018. The owner is a member of the Cherokee Nation. Tajour Specialty Products recently joined the Made in Oklahoma Program. To learn more about the business, visit www.tajoursp.com, www.madeinoklahoma.net/products/tajour-specialty-products-llc/ or find them on Facebook.