INTEGRIS is joining other hospitals and health centers around the country in a national effort to produce a stable supply of generic drugs. The venture is designed to address the growing frustration caused by persistent shortages of simple yet vital medications.
Utah-based not-for-profit generic-drug company Civica Rx is spearheading the initiative. “Drug shortages have become a national crisis, with patient treatments and surgeries canceled, delayed or suboptimal,” says Martin VanTrieste, chief executive officer of Civica Rx. “We thank these organizations for joining us to make essential generic medicines accessible and affordable in hospitals across the country.”
The benefit of the Civica Rx initiative is expected to be two-fold. Hospitals will not only have access to generic drugs that are frequently in short supply, but they will also be able to purchase those medications at a reduced cost. A savings that can then be passed along to patients.
“We are excited to be a partnering member in this venture,” says Tommy, Ibrahim, M.D., chief physician executive at INTEGRIS. “We enjoy a proud tradition of being a leading-edge health care provider known for a pioneering spirit that has paved the way for many medical firsts and technological advancements. We believe this initiative is another example of that. It is an innovative approach to providing quality, accessible, more affordable medicine to the citizens of Oklahoma.”
Civica Rx plans to bring 14 hospital-administered generic drugs to market in 2019. The overall vision is to become a model generic drug company that provides high-quality Food and Drug Administration-approved products at affordable prices.

Glioblastoma is an aggressive form of brain cancer with no cure. Even with surgery and chemotherapy, patients typically live only 12-18 months after diagnosis.
But a new discovery from Oklahoma Medical Research Foundation scientist Rheal Towner, Ph.D., offers new hope in fighting this deadly cancer, which claimed the lives of Sens. John McCain and Ted Kennedy.
In pre-clinical experiments at OMRF, Towner discovered that a protein called ELTD1 is present in the most aggressive glioblastoma tumors. Towner then tested how the tumors would react to an antibody known to counteract the effects of ELTD1.
He found that the compound slowed the process of angiogenesis, the growth of new blood vessels, which is key to tumors’ ability to spread and kill.
“This drug seems just as promising, if not better than, what is currently considered the standard of care,” said Towner. “Few therapies exist for treating glioblastoma, but this could provide a step in the right direction.”
If proven effective in further trials, said Towner, “This could provide overall treatment with fewer side effects and better results than we see in current drugs.”
The new findings were published in the journal NeuroOncology.
Towner will continue to look for ways to use the new treatment in combination with other drugs to boost their effectiveness and better target tumors.
“One problem with drug treatments for tumors is that it’s hard to get the drug to the tumor site,” he said. “If we can regulate that process with targeting ELTD1, we might be able to use it to deliver other drugs directly to the tumor and, hopefully, eliminate it.”
If researchers succeed with this tumor-targeting method, Towner said they will begin testing it on other tumors associated with breast, pancreatic or other cancers.
Funding for this research was provided by National Institute of General Medical Sciences, grant number 5P20GM103636-02, and Institutional Development Award (IDeA) from the NIGMS, grant number 5P20GM103639. The NIGMS is part of the National Institutes of Health.

As new state leaders are sworn in today, John D. Doak reflects on his eight years as Oklahoma’s insurance commissioner. Doak was elected the state’s 12th insurance commissioner in 2010 and was re-elected for a second term in 2014.
“I’m honored that Oklahomans chose to elect me to represent them, both in terms of insurance company solvency and ensuring fair claims handling,” Doak said. “I’ve been privileged to witness the courage and resilience of Oklahomans in the face of difficult natural disasters. It’s also been a pleasure to work with our state Legislature and governor and to travel to every one of Oklahoma’s 77 counties, meeting and working with the people who live there.”
During his tenure, Doak has tirelessly worked to raise awareness of the Oklahoma Insurance Department (OID) and how it can help Oklahomans. He started a field representative program to reach every corner of the state. He also made it a mission to have boots on the ground as soon as possible after a disaster. Many times Doak himself would visit with storm victims to reassure them that his office was there to help, if needed.
Another issue Doak worked on during his time in office was lowering the rate of uninsured motorists. Oklahoma has one of the highest rates in the country. Just a few months ago, the OID announced it would host the Auto Insurance Verification System which allows law enforcement to verify a driver has insurance in real time.
“One of my proudest accomplishments is that, as I leave the OID, it is now being recognized as a global leader in insurance regulatory issues,” Doak said.
Doak’s recognition that government must be ready to accept new and innovative ideas and products has helped frame that thinking. His belief that the OID should not only to protect consumers but allow the free market process to bring new quality products to consumers is recognized by many leaders worldwide.
More of Doak’s accomplishments include:
*Recovering $27,675,828 for Oklahomans since 2011
*The passage of House Bill 2308 which allows the OID to construct and own an office building
*OID employees earning more than 160 professional designations
*Co-hosting the National Tornado Summit since 2011
*The passage of the Insurance Business Transfer law
*Developing an earthquake education requirement for insurance professionals
*Testifying before a U.S. Senate sub-committee about insurance fraud
*Helping launch the University of Tulsa Cyber District
“I wish the best to the new leaders of our state, Gov. Kevin Stitt, Lt. Gov. Matt Pinnell and Insurance Commissioner Glen Mulready,” Doak said. “Commissioner Mulready has already proven that he is a dedicated public servant with expertise in the insurance industry, and he will continue that tradition in this new role.”

A chocolate Labrador Retriever named Penney and a passion for old maps led to a unique business opportunity.
“I am nearing retirement and decided if wanted to retire to the country where Penney would have a place to run, I would need to have a small business to make ends meet,” said Mike Howard, owner of Penney’s Territorial Maps.
After collecting old maps for many years, Howard began copying them and hanging them up at work and in his home. One thing led to another, and before long people were requesting them.
“We have about 30 shops in northeast Oklahoma who stock and sell the maps,” Howard said. “I have really been surprised at how well the maps have been received… The business is expanding to other states, and I now have dealers in Texas, Arkansas, Missouri and Kansas. I should be in New Mexico and Colorado by the end of 2019.”
Howard reproduces the old maps that are artificially aged and then sets them in rustic wood frames. Howard said he loves the reaction his customers have to his maps.
“I love hearing all the stories about their family’s history, looking for long lost towns, or pointing out where their land run claim was,” he said. “I have learned so much history about Oklahoma just talking to customers about the maps. I feel customers love the maps because it gives them a link to the past.”
Established in November 2016, Penney’s Territorial Maps joined the Made in Oklahoma Program this year. To learn more about the business, visit www.madeinoklahoma.net/products/penneys-territorial-maps/ or find them on Facebook.

The stabbing pains in David Key’s armpits awoke him from sleep one night in 2006. “It was excruciating,” said Key, 53, who lives in Oil Center, about 10 miles northeast of Ada.
He cycled through hospitals and clinics, his condition worsening. He developed uncontrollable tremors and neurological problems and gave up his business. After a pair of strokes, he was forced to go on disability. Years passed, yet still he had no answers.
Finally, one physician thought he recognized Key’s condition. A subsequent biopsy of lymph nodes proved the hunch: sarcoidosis, a rare disease that causes lumps of immune cells – known as granulomas – to form in organs throughout the body.
“Unless patients’ first symptoms are in the lungs, they’re usually misdiagnosed,” said Courtney Montgomery, Ph.D., who studies the disease in her lab at the Oklahoma Medical Research Foundation.
Scientists know little about what triggers sarcoidosis. It seems to start in the immune system, eliciting rampant inflammation. The tumor-like lumps can appear in the eyes, liver, heart, skin and brain and, most often, in the lungs.
The disease can strike anyone, but it disproportionately affects African Americans. And, said Montgomery, it can be fatal.
“The most common causes of death are cardiac conditions,” she said. Heart complications claimed the disease’s two most famous victims – NFL Hall of Famer Reggie White and comedian Bernie Mac – at the ages of 43 and 50, respectively.
For Key, doctors have largely managed to control his symptoms through steroids and long list of other medications for the tremors, pain, depression and neurological issues. Still, he continues to experience near-constant pain in his chest. “Sometimes, I can swear I’m having a heart attack,” he said.
Last year, in an effort to help Montgomery and her OMRF scientific team better understand the disease, Key traveled to Oklahoma City to participate in a research study of sarcoidosis at the foundation. After filling out questionnaires detailing his disease and medication history, he donated blood for the researchers to analyze.
“By studying what’s going on at a genetic level in patients with active disease, we hope to identify environmental triggers that initiate sarcoidosis,” Montgomery said. Ultimately, that work might point scientists to an effective treatment.
Key understands that volunteering in OMRF’s research study likely won’t help directly. Still, he said, “If it can help somebody down the road, it’s worth it.”
For more information about sarcoidosis or to participate in research studies of the disease at the Oklahoma Medical Research Foundation, call (405) 271-2504 or email [email protected].

What brings you joy in your life? Salvation Army Central Oklahoma Area Command

What really brings me joy is when my three boys have success in their personal life. Rick Dimit

The fact every day I can come here and have an opportunity to be Jesus’ hands extended. Dee Watts

Staying active … and playing pinball. Hugh Osborn

Seeing my friends every day and having my family close and working here brings me joy. Deanna Waltens

By Darlene Franklin

“Why should I be afraid?” Israel’s greatest warrior king, David, asked in Psalm 27.
These past few months, I could have given him a few reasons from the “disease that stalks you in darkness” (Psalm 91:6, NLT) category. It started with a pulmonary embolism that could have taken my life and progressed to a succession of less threatening but still uncomfortable and debilitating ailments, most recently the need for cataract surgery.
Given my propensity to anxiety, I decided to proactively arm myself with encouragements not to give in to fear. When I opened my Bible, I discovered that every time it tells me to not be afraid, it also gives a reason.
If often also gives additional instruments. “Just” do this instead. As I adjust my attitude, my fear level drops.
“Just stand still and watch the Lord rescue you today.” (Exodus 14:13 NLT bold face mine and also in the paragraphs below)
In the words of the Desiderata by Max Ehrmann, “No doubt the universe is unfolding exactly as it should.” Given time, most issues will resolve themselves.
Yes, there are times I’m supposed to get to work or even go on the offensive. But I start by standing still. I’m not in control, and why do I want to be? God is so much more powerful than I am on every level.
“The Lord himself will fight for you. Just stay calm.” (Exodus 14:14 NLT) The phrase “stay calm” follows on the heels of “standing still” in the Bible, suggests the two work hand in hand. “Stand” involves physical action, to maintain an upright position while on one’s feet, without wavering. In this case, “stay” works more like “to be.” I can stand still because I am calm.
“Still” implies calm. I am undisturbed by outside forces, not showing or even feeling strong emotion, e.g., fear.
“Just open your eyes and see how the wicked are punished.” (Psalm 91:8 NLT.)
Take a look at the larger picture. When the doctor told me, I had blood clots in my lungs—not one but two—I was unaware that that I had already passed the first test to survival. I hadn’t died in a heart attack as soon as they developed.
Recently, I spent eight hours in emergency room because of chest pain which turned out to be nothing worse than gastric difficulties. Over the long hours I spent watching the ER fill, empty, and fill again with new patients, I opened my eyes to those in much worse shape than me. I could afford to wait while newborn babies sick from pneumonia cried feebly and accident victims hovered on the brink of life and death.
“Just remember what the Lord your God did.” (Deuteronomy 7:18-21 NLT)
Remember the past. Was I frightened the last time I went through a similar experience? When the doctor warned me that the surgery was very serious, implying “and you could die.” Of course! I was afraid, but at peace—and I survived.
The more often something like that happens, the easier it becomes to remember God’s in control. Whether I live or die, I can trust him. The heart and mind connect what I’m learning from my Bible study and what’s happening in my life more clearly. Past experience increases my confidence that God has a purpose behind the current trial that’s tempting me to fear.
“Just have faith.” (Mark 5:36 NLT)
This guideline feels obvious—except the person who was told to have faith had every reason to doubt. Jairus, a leader in his synagogue, had come to Jesus when his daughter was deathly ill. Before they reached the house, he received word that his child had died.
Jesus’ response to the news? “Just have faith.” Minutes later He raised the girl from the dead. But if I had been Jairus in that moment, I would have felt like screaming, “I had faith. I came to you.” Undercurrent: You failed me.
Jesus encouraged Jairus to continue in the same faith he’d started out with. To trust God even in his bleakest moment. And sometimes I’ll be called on to trust in the face of massive disappointment, impossibility, and personal pain.
The next time fear comes knocking at the door, let’s remember these five principles so we can face those challenges with courage. God is on our side, and He’s always more powerful than what’s happening.

by Bobby Anderson, Staff Writer

Like many, Karyl James, MSN, BSN, RN, Mercy Hospital CNO watched the frequent headlines marking deadly shootings.
And the reports of violence inside health care showed no signs of slowing down.
But what happens if the two scenarios combined? It was a question James and others in the Mercy system really didn’t want to think about, but one they knew they had to answer.
“With all the public shootings going on our safety team in collaboration with nursing said we have to educate and do something about it,” James said recently.
Through planning, discussion and scenarios Code Roscoe was born.
The code is Mercy-wide, so all 45 hospitals in the system use it for any active shooter situation.
Each unit must have at least two identified safe places that can prevent a shooter’s access to people.
“It’s not just nursing it’s registration, it’s all of those individuals. The front door of the hospital is registration so they need a safe place,” James said.
Planning for the unknown is a constant battle. Knowing who might have a gun is another.
A former ER nurse, James is familiar with both.
“Unknown was just kind of second nature for me and personally, I’ve had a gun pointed at me as an ER nurse many years ago,” James said.
It was an eye-opener to say the least.
“Yeah, I’m going to die. It was frightening,” James said of what flashed through her mind all those years ago. “He was not in his right mind and pulled out the revolver. Luckily, I had a police officer right next to me and he grabbed the gun.”
“The worst we can do is say ‘Oh, that will never happen to me because it might.’”
James knows working without a plan would shortchange everyone. That’s why she’s invested in the planning, hoping it will never be put to use.
The first drill that was run pointed out several instances where locking mechanisms didn’t work the way they should have.
The second time the code was called it wasn’t a drill.
“I got that call on a Sunday afternoon and I just froze,” James said of the scenario where the hospital locked down after a suspect in a nearby neighborhood was seen with a gun. “My stomach just sank because there was no drill.”
Out of instinct the first thing James did was call the house supervisor. That wasn’t protocol.
“The first thing you do is turn your phone off and text only,” James said. “I was the administrator on call.”
The house supervisor did answer and whispered to James she and several others were huddled under a table in the nursing administration offices.
“There was no lock on that door so they had the table pushed against the door,” James said. “The larger space you could just walk in. We’ve since put a badge reader on that door.”
Officials also learned the emergency locking button that seals all doors in the emergency department did not work.
“You could literally walk up and push open our ER so we got that fixed,” James said. “It really kind of opened our eyes to a lot of the safety measures we thought we had but really didn’t.”
Mercy has had Code Roscoe in place for nearly three years now. It’s evolved along the way.
“The reason I feel good about it is because the co-workers feel good about it,” James beamed. “After that actual event I went to the hospital after it was all said and done. It was a grueling 45 minutes because that was about how long it took for police to subdue the individual shooting in the neighborhood. I rounded on staff.”
“They knew exactly what to do. They knew where their safe spots were and the locks worked. They felt safer. For me, that’s a win.”
Planning for the unexpected is challenging to say the least.
“There’s always something new and I think you have to be flexible to understand you don’t have everything figured out and you never will,” she said.
“I get shocked every day with something new. Being open to accepting that and training as much as you possibly can for those bigger events – coworkers will figure out what they need to do and what is right to do for their patients and their safety.”