Tuesday, December 2, 2025

INTEGRIS Deaconess Announces New President

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Rex Van Meter, president of INTEGRIS Deaconess.

INTEGRIS assumed operations of Deaconess Hospital and its affiliated family care clinics at midnight, Oct. 1.
Rex Van Meter is the newly named president of INTEGRIS Deaconess, as it is now called. The hospital is considered a campus under the INTEGRIS Baptist Medical Center umbrella.
Van Meter has been a part of executive leadership at INTEGRIS since 2001. He joined as vice president of finance at INTEGRIS Blackwell Hospital and was promoted to president there four years later. In 2012, he was named president of INTEGRIS Canadian Valley Hospital, and has led that facility to successive year-over-year record performances. Van Meter earned a bachelor of accounting from Northwestern Oklahoma State University and a master of health care administration from Trinity University.

Social Security Announces 2.8 Percent Benefit Increase for 2019

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Social Security and Supplemental Security Income (SSI) benefits for more than 67 million Americans will increase 2.8 percent in 2019, the Social Security Administration announced today.
The 2.8 percent cost-of-living adjustment (COLA) will begin with benefits payable to more than 62 million Social Security beneficiaries in January 2019. Increased payments to more than 8 million SSI beneficiaries will begin on December 31, 2018. (Note: some people receive both Social Security and SSI benefits). The Social Security Act ties the annual COLA to the increase in the Consumer Price Index as determined by the Department of Labor’s Bureau of Labor Statistics.
Some other adjustments that take effect in January of each year are based on the increase in average wages. Based on that increase, the maximum amount of earnings subject to the Social Security tax (taxable maximum) will increase to $132,900 from $128,400.
Social Security and SSI beneficiaries are normally notified by mail in early December about their new benefit amount. This year, for the first time, most people who receive Social Security payments will be able to view their COLA notice online through their my Social Security account. People may create or access their my Social Security account online at www.socialsecurity.gov/myaccount.
Information about Medicare changes for 2019, when announced, will be available at www.medicare.gov. For Social Security beneficiaries receiving Medicare, Social Security will not be able to compute their new benefit amount until after the Medicare premium amounts for 2019 are announced. Final 2019 benefit amounts will be communicated to beneficiaries in December through the mailed COLA notice and my Social Security’s Message Center.
The Social Security Act provides for how the COLA is calculated. To read more, please visit www.socialsecurity.gov/cola.

SYNERGY HomeCare

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Weama Kassem, CEO and President of SYNERGY HomeCare with Jeff Aynes who recently joined the SYNERGY Home Care Team as their Director of Sales and Marketing.

Expanding and strengthening their team and service

SYNERGY HomeCare proudly opened their doors over 5 years ago in Edmond, Oklahoma. Weama Kassem, CEO and President of SYNERGY HomeCare, has always dreamt of having a business that centered around caring for others; specifically, our aging community. Weama has been fortunate enough to attract a team of professionals with the same heartfelt drive and talent. The people Weama has assembled have accomplished some incredible things by always putting their clients’ needs and happiness first. The SYNERGY HomeCare team always refers to each other as “SYNERGY Family” and they work together to create an atmosphere of care and respect for each other and for their clients and families.
Weama opened her second office in December 2016 in Norman, Oklahoma. This enabled the company to reach and connect a larger clientele and reaching beyond Edmond and Oklahoma City. One of the most essential guidelines in opening the new location has been to duplicate their high standard of care. SYNERGY HomeCare does not use contracted caregivers, all are employees who must completed in-house training, along with continued monthly and quarterly training programs. This ensures the caregivers are not only qualified, but it strengthens the support and bonds within the company itself. Each caregiver is a Certified Nursing Assistant and/or a Certified Home Health Aide. They are each insured and bonded by SYNERGY HomeCare and strive to provide excellent care and support to both clients and their families.
SYNERGY HomeCare is very pleased to announce that Jeff Aynes has joined the SYNERGY Home Care Team as our Director of Sales and Marketing. Jeff has been a strong advocate for health care in Oklahoma for many years and will make a great leader on our team. Jeff is a father of two beautiful ladies and grandfather of two beautiful girls. He went to the University of Central Oklahoma and Oklahoma State University where he studied Marketing, Public Relations, and Broadcasting. Jeff is a Past President of Marketing Plus for Healthcare and currently serves as Secretary. He is currently serving as President of the Northside Marketing Alliance, as well as, Secretary. He has served in the community for many years as a member of the Shriner’s, Scottish Rite, Eastern Star, Amaranth, and Masons where he is a Past Master. He has been volunteering with Muscular Dystrophy, Cerebral Palsy Association, and Make Promises Happen Camp for over 25 years. His passion outside of Sales and Marketing is music. He has owned Jammin’ Jeff Entertainment for over 25 years and has performed over 1,800 events. Jeff joins the SYNERGY staff from AllianceHealth Midwest where he served as Director of Marketing for the Behavioral Health Program. Prior to going to AHM, Jeff served for over 5 years at Absolute Senior Care of Oklahoma City and A Premier Senior Home Care of Tulsa as their Director. We are beyond thrilled and honored that Jeff has chosen to join our team and know he is truly a valuable asset that will provide wonderful support to our growing company.
Together, Weama and Jeff, will be able to provide assistance to our aging community, education to our referral partners, knowledge to our team of growing caregivers, and a bright and smiling face to see each time you encounter them. Serving people is what SYNERGY HomeCare does every day and it is truly the drive and passion of both Weama and Jeff. With over 100 caregivers and five years in business, the SYNERGY HomeCare team stands ready to answer specific questions about care.
Whether you are a senior living on your own, with an aging spouse, or you have an aging parent – there are some key things to keep in mind when selecting a home care company. First, is the home care company licensed in the state? Companies are reviewed annually to determine their eligibility, and this is a perfectly normal question to ask a potential company. Ask to see a copy of their business license. Second, ask if the caregivers are employed by the company instead of being contract labor employees. It may seem beneficial to contract our work, but actually you can face many liability and scheduling issues down the road. Ask the provider to include client AND their family members in developing the plan of care. SYNERGY HomeCare has full-time RNS on staff to specifically build a plan of care for each new client and they spend the time you need to sort out every little detail. Lastly, ask for a list of references so you can check in on who you are considering to employ! We are all use to providing references when applying for a job. SYNERGY HomeCare is happy to answer questions like these anytime.
SYNERGY HomeCare is a group of Oklahomans that you can trust. Weama, Jeff, and the whole team are honored to provide care to this amazing community and welcome your call anytime, day or night!

SYNERGY HomeCare is located at 13720 N Bryant Ave. Edmond, OK 73013 405-254-3046
www.synergyhomecareedmond.com

 

Soul searching: Seniors publish new book

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A group of senior friends published a new book that takes a look at the undercurrent behind today’s political climate.

by Bobby Anderson, Staff Writer

A sociologist, a psychologist and a benedictine nun walk into a room.
Sounds like the beginnings of a good joke.
But for John Karlin, PhD, those are just a few of the cast of characters that helped create his new book: Fear, Religion, Politics: Well I’ll Be Darn!
Karlin spent the last year of his life writing this book that takes a look at the intertwining of three things deeply personal to Americans.
“It was incredible in the sense that how much insight humans have but not realize it,” Karlin said. “In researching this I kept seeing these little lights in other people’s works.”
Karlin was aided by Dr. Melvyn Preisz, Rhonda Bell, Judy Martin, Marsha McMillin, Gerry Lantagne and others in developing his second book. Each brought their own unique talents.
Preisz is a local clinical psychologist who befriended Karlin years ago.
“I agree with Dr. Karlin’s timely and insightful assessments of this unprecedented crisis,” Preisz said. “From my own psychological viewpoint, these enemies of our individual freedoms collude to divide and conquer the good within us, and to continue to attack our personal conscience from a buffet of lies.”
Karlin stresses he has no political motives with this book.
His wish for what readers walk away with is simple.
“Simply an understanding of those undercurrents, a complete, full, intense understanding of … what’s actually happening underneath the surface,” Karlin said. “I just expose those undercurrents, that was my whole concern. I write from a sociological perspective.”
“I’m not the only one who has picked up on this. What I found is pieces of those themes in many, many other works.”
Karlin cites some 120 references in his work, that he says was a labor love performed with dear friends.
“Our intent was to give seniors out there a message that you can do stuff like this. You’re never too old,” the 72-year-old Karlin said. ”Don’t just sit, you’re capable of doing stuff.”
More than 20 years of Karlin’s life have been spent in teaching, largely at Northwestern Oklahoma State in Alva, Oklahoma City University and Phillips University.
While teaching sociology and criminal justice at OCU, Karlin begin his friendship with Preisz.
Preisz introduced him to Lantagne, who introduced Martin, a former Benedictine nun and things began falling into place.
“It was just friends introducing friends,” Karlin said. “It was basically happenstance then realized ‘Gosh, look at all this talent.”
The motives were simple.
“I just didn’t like the way things were going in this country especially politically and socially in terms of the turmoil and discontent,” Karlin said. “I thought there had to be something underneath that. As a sociologist you always know that what’s on the surface isn’t always the whole story.”
“Sometimes in our culture there are some very deep undercurrents that help explain.”
Karlin recalled attending Louisiana State University for his doctorate. A conversation with an old fisherman came to mind.
The fisherman pointed to the Mississippi River and told Karlin to watch it closely.
“It’s just real slow, old man river kind of thing but underneath that is just incredible turmoil,” Karlin said. “The Mississippi in spots is almost a mile deep and a lot of people don’t realize that because the undercurrent is cutting it.”
“There are literally complete trees down there. That’s the way culture and society can be.”
That got Karlin thinking about what’s underneath today’s politics and headlines.
“What’s under that is not good,” he said.
Karlin’s book flows through three sequences with the first being our innate fear of death and how we view our own mortality.
“And how that came to actually produce the phenomena we call religion in society,” Karlin said. “Any religion, it doesn’t matter what it is, came from the fear of death because religion was a way to escape that tension and fear.”
The second sequence evaluated Christianity and the life of Jesus Christ.
“I looked at what (Jesus Christ) was actually trying to accomplish in his own time and he was trying to accomplish something,” Karlin said. “You’ll find that as somewhat of a shocker.”
The third sequence takes things into the political realm.
“That’s where the dream goes awry because a big chunk of our Christian community want to blend religion and politics to the point where they are no longer distinguishable and that’s not good,” Karlin said.
“That’s what has created most of the problems you see in society today. Basically, it’s the drive towards theocracy.”
Karlin’s book is now available on Amazon. He will do a benefit book signing for the Peace House at the Peace Festival at the Civic Center Music Hall November 10 from 10 a.m. to 4 p.m.
The Peace House will get $5 for every book sold.

Significant Women in Ok Agriculture: Jerri Wilson

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Jerri Wilson of Loco is being recognized as a significant woman in Oklahoma agriculture.

by Bryan Painter

Jerri Wilson at 10 years old showing her home-raised Angus show steer.

LOCO – Cattle and horses over people.
Jerri Wilson, raised near Duncan in southern Oklahoma, made that choice about the time she was still shedding baby teeth.
Horseback at every opportunity, Wilson would carry her lunch around in her saddle bags. Why?
“If it was even mentioned about going to town,” she said, “I became scarce out in the pastures.”
She was born to Billie and (Ed) John E Jackson, Jr. and grew up on the commercial Angus cow-calf ranch in southern Stephens and northern Jefferson counties. Ed Jackson purchased the ranch the year Wilson was born, 1959, and expanded it to 23,000 acres.
Billie and Ed had four daughters. Their names started with J so it was called the 4J ranch.
Wilson was the youngest and grew up following her father around taking care of the cattle.
“The others did not take up much to cattle and the country life,” she said. “I was quite the tomboy, staying out with the cattle all day.”
Wilson’s love for taking care of cattle and the land was not a secret. Everyone could see it.
“Our ranch was far from school,” she said. “I was the first one on and the last one off the school bus for two hours each way and spent many hours looking at cattle and pastures along the way.”
Add those round-trips up from grade school through high school and that’s a lot of miles.
Not long after the bus came to a stop near their house, Wilson was out on her paint pony riding through the cattle and across pastures.
“At branding and shipping time,” she said, “myself, and the other kids on the ranch were in the mix of helping. I thank all of the adults from back then for allowing us to be there because it was what shaped my future.”
More responsibility
As she got older, Wilson’s responsibilities grew. She worked cattle, took care of the cattle and horses, and doctored the sick ones.
Wilson also began showing cattle at the county and state level.
“I really think that was the point that I knew I would always have cattle in my blood,” she said. “At that time, everyone would show home-raised steers. I remember running down to the barn and feeding in the dark before getting on the bus.”
At 13, she showed heifers, but they had to be registered.
“I was fortunate that our neighbor, Mr. Phil Lowery, raised registered Herefords for years,” she said. “I had been riding my pony up the road to help him gather his cattle and I told him I needed to buy one of his heifers to show. He said, ‘Pick one out.’”
Lowery gave her a heifer every year through high school as payment for helping him with his cattle.
“His operation was much different than our commercial herd,’’ Wilson said. “I would ride around in his pickup with him and listen to all the pedigrees.”
Lowery kept little breeding books, with a rubber band around them, on his dusty dash. Wilson studied those little books.
“I built my first herd with those registered Herefords and still have a little Hereford patch for sentimental reasons,” Wilson said.
One of her other passions was livestock judging and grass identification. She went to numerous contests and loved all the aspects of learning.
4-H was a big part of her life, and the horses she took to 4-H and Quarter Horse events were not only for showing.
“They were also my cow horses back on the ranch,” Wilson said.
In high school, she started going to the state high school rodeos. That’s where she met her future husband Bob Wilson. The two married after high school, in June, 1977.
“For a couple of years we lived in Elk City,” she said. “Bob worked there during the oil and gas boom and of course I dragged a few cows along with us.”
As her Dad was getting older, he had heart problems, so Bob and Jerri returned to Ed’s ranch where they lived and worked.
The Wilsons had three daughters, Kristy, Kerri and Kayla.
When Jerri Wilson’s father passed away, the family dispersed the ranch and cattle.
Wilson, 30 years old at the time, and Bob, began their own ranching operation near Loco. They put together enough acreage to get a start, so they bought four loads of commercial Angus bred heifers.
“The timing was not great,” Wilson said. “The cattle market was on a low, so Bob began driving a Peterbilt with a flatbed.”
Bob hauled nationwide for a local wire plant which allowed “us to let the cows pay for themselves.”
“As soon as that was done, he stopped,” she said.
While he was gone, Wilson was feeding cattle and taking care of their first grandson.
“By now our two youngest daughters were beginning to show cattle and loved it,” Wilson said. “It had changed dramatically from my days. Hair products and clipping were much different. There was a lot of learning to do.
“Along the way I bought a couple of Simmental heifers for them to show and liked the way they performed and their temperaments.”
So, from artificial breeding the heifers, and purchasing some purebred and percentage bulls, they started breeding Simmental into their cow herd.
“Now we have a SimAngus cow base and have been breeding them to registered Angus bulls,” she said.
A dusty memory
During the fall of 2010, it seemed the Oklahoma skies had started to dry up.
Rains became a dusty memory.
“We had some really tough years during the drought,” she said. “From 2010 to 2013 we culled our cow herd by a third because there was no pond water. We had some wells dug for them but it is very hard to get water in this area.”
Plus, in February 2011, Bob broke his wrist in a shop accident.
“Then in August, him and his horse parted ways on a large crack in the ground from the drought and he broke his hip,” Wilson said. “It was a very tough year for him.”
A hired hand helped for about three years before moving back to Nebraska. Challenging decisions had to be made.
“At the time, there was not enough water so the calves were taken off at 400 pounds and we sent them to a feedlot which is not what we normally do,” she said. “Normally our calves are left on the cows till they are 500 to 600 pounds.
“In the end it improved our cowherd into productive beautiful cows that I am very proud of. We have been selling a lot of our heifers for breeding or as bred heifers. Steers and heifers not for breeding are sold through National Livestock at the Oklahoma City stockyards or sold at home.”
Over the years, Jerri and Bob have purchased more land and have doubled their size from what they started with, “which has been gratifying to improve those areas.” They have done a lot of clearing brush, sprigging Bermuda and weed spraying to improve the grass for cattle, while yet always being mindful of the wildlife.
They are also mindful of the future. In addition to three children, they have six grandchildren.
“So who knows, maybe some of them will continue in a ranching lifestyle,” Wilson said. “In the cattle business it’s a lot of long days and hard work but it is a lifestyle that I love and have a passion for.”

Centerpiece to be added to Oklahoma Memorial

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With the installation of a twenty-four foot Blue Light Centerpiece this week, the Oklahoma Law Enforcement Memorial added the final piece to the newly repaired and renovated memorial plaza. The Oklahoma Law Enforcement Memorial is the oldest state law enforcement memorial in the United States, dedicated on May 15, 1969. A few years ago it was discovered the memorial was sinking after almost fifty years of withstanding Oklahoma weather and rain water flowing over and apparently under it. Donations were made and the work to repair and renovate the memorial started on December 15th of last year when the memorial stones were taken up and stored. The renovated memorial was for the most part completed and was rededicated during the Fiftieth Annual Memorial Service on May 18th of this year. The center piece was the only part not ready by the service.
This Sunday, November 4th at 5:30 p.m. during the Oklahoma Chapter of the Concerns of Police Survivor’s Annual Blue Light Ceremony the perpetual Blue Light Center Piece will officially be turned on as a constant reminder of the service and sacrifices of our law enforcement officers. The memorial is located on the west grounds of the Oklahoma Department of Public Safety Headquarters, 3600 M. L. King Avenue in Oklahoma City. The public is encouraged to attend.
The names of over eight hundred officers who have died in the line of duty in Oklahoma, both before and after statehood, are engraved on the memorial. See the memorial’s web site at www.oklemem.com for more information on the memorial and Oklahoma’s fallen officers.

FAIRest of them all

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Mike and Belinda Winslow, owners of Cutie Pies Concessions, took first place for their watermelon pie at the State Fair of Oklahoma.

by Bobby Anderson, Staff Writer

This fall has been pretty sweet for Belinda Winslow and husband Mike.
In September, she received the blessed news that her 27-year-old daughter was finally cancer free.
October saw her Watermelon Pie creation clean up in the awards category at the Oklahoma State Fair. The pie, an old recipe from her childhood, earned the FAIRest of Them All award as the best overall food creation. The fruity, creamy treat also was named the top overall sweet offering at the fair, dubbed Sweetest of the Sweet.
“We’ve had a good year this year,” Belinda Winslow smiled.
Going up against eclectic creations like deep fried coffee, Frosted Flakes chicken on a stick and Kit-Kat fries, Winslow’s watermelon pie blew away judges at the Great TASTE of a Fair competition which immediately precedes the September fair.
The event, staged to whet appetites and drum up publicity for the fair, was Winslow’s coming out party for her mobile food truck business.
Based out of Moore, the Winslows opened their trailer for business in March 2015 after scores of friends and family kept insisting they bring the watermelon pie to every gathering.
Winslow said some of those invites may have just been for the pie, but it was clear she had something on her hands that people really liked.
“It was a recipe my mom came across and she just loved it and we started making it,” Winslow said. “It just stuck.”
So did the idea of opening her own business. Her and her husband, who runs a full-time paint contracting business, began drawing up a business plan months earlier.
Cost projections outpaced savings for opening a traditional brick-and-mortar business.
“The food truck was the first thing we could think of,” Winslow admitted.
A business on four wheels came with its drawbacks.
Running a business in a trailer meant more prep work. Winslow typically makes her runs to Sam’s Club, Wal-Mart and the Chef Store the Tuesday before an event. Six to seven hours the following day are spent doing prep work, including cutting up some 20 to 25 watermelons by hand.
“It’s hard work, very hard work,” Winslow said of the business. “It’s not something you could just do on a part-time basis. It’s a full-time job.”
“You’ve got to pack it up, move it and have it ready on time.”
The concept also came with advantages.
Being on wheels means that Cutie Pies can be at almost any venue in the state with enough advance notice.
This month the trailer will pull up to Norman and the University of Oklahoma Day of the Dead Celebration. The following day Cutie Pies will be at Integris Baptist with 100 pies for a private event hosted by the radiology department.
Twelves days later you can find watermelon pie at the Luther Pecan Festival.
Outside of the State Fair, Winslow said one of the company’s best events is always the The Old Chicken Farm Vintage Barn Sale in Jones.
It’s a good thing Cutie Pies gets around because it will take you awhile to work through the menu. Watermelon pie may be the star but there’s a talented ensemble cast of banana cream cheesecake, root beer float pie, cherry limeade pie and cotton candy pie.
If sweet isn’t your thing they have savory covered, too, with Winslow’s chicken and corn frito pie.
The twist on the original frito pie includes santa fe chicken layered on Fritos doused in queso cheddar cheese mixed with feta, cilantro and a special chili lime mayo.
Wash it all down with a variety of lemonades – including watermelon, of course.
“This our first year to actually make money,” Winslow said.
And that’s despite a trying year.
Winslow’s daughter battled stage IV ovarian cancer before doctors announced she was cancer-free three days after her last surgery.
Through it all, Winslow has been her daughter’s caregiver, keeping her out of the truck for most events. That’s meant Mike pulling double duty.
“He’s been our savior. He’s saved both of our businesses,” Winslow said of her partner of 20 years.
But it all paid off this fall.
“It was kind of Heaven-sent because (my daughter) finished chemo and we had the fair,” Winslow said. “Right after the fair she had her surgery.”
“But she was still out there.”
All three of Winslow’s kids help in the business including a 21-year-old daughter and a 38-year-old son.
Her two granddaughters pitch in, too.
“They come stay with us every other weekend,” Winslow said. “They love to work on the truck and they hope we have leftovers, which doesn’t happen very often.”
So what’s next? Can she top Watermelon pie?
“I have somethings in the works for next year but I can’t tell you,” Winslow laughed.
You can find out where Cutie Pies Concessions will be next through their Facebook page.

What will be on your Thanksgiving plate?

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What will be on your Thanksgiving plate? Norman Regional Hospital Auxiliary

Ham and dressing, gravy, green beans. Maybe a little turkey and hot rolls.

Derald Fendley

We’ll be eating off the same menu but my favorite is cornbread dressing.

Jan Fendley

The usual turkey and dressing but also rutabagas and red cabbage.

Jonnina Benson

Turkey and dressing with candied yams, and pumpkin pie with lots of whipped cream.

Dixie Hurd

Rhoades Named Oklahoma State Department of Health Chief Medical Officer

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Dr. Edd Rhoades as Chief Medical Officer.

Oklahoma State Department of Health (OSDH) Interim Commissioner Tom Bates has appointed Dr. Edd Rhoades as Chief Medical Officer for the agency. Dr. Rhoades has been with the agency for 40 years and is currently serving as the Medical Director for Family Health Services.
“Dr. Rhoades has served the state and this agency with integrity in a number of key positions over the years and it is appropriate that he should be the first person to fill this important role,” said Commissioner Bates. “The establishment of a Chief Medical Officer aligns with the public health structure of many other states and will provide guidance to our core mission.”
The Oklahoma State Board of Health approved creation of the position at their Sept. 14 meeting, following a recommendation that was included in a corrective action plan provided to the legislature in January. The Chief Medical Officer will advise agency leadership on medical and public health issues and provide medical oversight and consultation to agency service areas and county health departments. Under the current organizational structure, the Office of the Commissioner continues to focus on improving the financial operation and organization of the agency to ensure efficient delivery of core services.
A graduate of the University of Oklahoma School of Medicine, Dr. Rhoades also holds a Masters of Public Health in Health Administration from the University of Oklahoma College of Public Health. He is a Diplomate of the American Board of Pediatrics and has received numerous awards for his work in maternal and child health and environmental protection. Among his honors are the Joan K. Leavitt, M.D. Award from the Oklahoma Public Health Association and the Mike Synar Environmental Excellence Award.
“I’m looking forward to working with Commissioner Bates and the senior leadership team to provide guidance for the agency as we continue to focus on issues that will improve the health of all Oklahomans,” said Dr. Rhoades. “I’m honored to have this opportunity to share my experiences and promote the great work being done by all of our public health professionals.

New findings cast light on lymphatic system, key player in human health

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Oklahoma Medical Research Foundation scientist Satish Srinivasan, Ph.D.

Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
The lymphatic system is a network of vessels and lymph nodes that spans the entire body. It is critical for good health and for the body to function properly. Defects in lymphatic vessels cause lymphedema, a disease characterized by dramatic and painful swelling in the limbs that often leads to infections.
Lymphedema can result from congenital mutations, surgery, radiation treatment for cancer or infection, and there is currently no cure. In addition to lymphedema, defects in the lymphatic system have been linked to a wide range of health consequences: cancer, atherosclerosis, Alzheimer’s disease and obesity.
Sathish Srinivasan, Ph.D., and Boksik Cha, Ph.D., at OMRF previously discovered that a particular pathway—known as the Wnt signaling pathway—regulates the development of the human lymphatic vascular system. In new research, published in the journal Cell Reports, they’ve found “the nuts and bolts of this important pathway.”
“We have identified the signaling molecules that activate this pathway,” said Srinivasan. “We also have learned which cells produce the signaling molecules, how they are sensed by the cells and how they are used in lymphatic development.”
Srinivasan was recruited to OMRF from St. Jude’s Children’s Research Hospital in 2013. His lab at OMRF has already identified several target genes for lymphedema. Srinivasan said that, after further study, this new information could eventually help researchers develop better therapeutic options for lymphedema and associated disorders.
“This signaling pathway has proved difficult to study, because it is complex and so little is known about how it functions normally, let alone when it goes wrong,” said Srinivasan. “Wnt signaling is aggravated and increased in breast cancer and colon cancer, but it is deregulated in diseases like Alzheimer’s and lymphedema.”
Srinivasan said drug companies are interested in finding molecules that can be targeted, either to promote or inhibit Wnt signaling, depending on the disease. “Our goal is to find whether such drugs could be used to treat humans with lymphedema and see if their disease can be managed, made less severe or even cured,” he said.
Other OMRF researchers who contributed to this research were Xin Geng, Ph.D., Riaj Mahamud, Lijuan Chen and Lorin Olson, Ph.D.

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