Tuesday, February 3, 2026

What will be on your Thanksgiving plate?

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What will be on your Thanksgiving plate? Norman Regional Hospital Auxiliary

Ham and dressing, gravy, green beans. Maybe a little turkey and hot rolls.

Derald Fendley

We’ll be eating off the same menu but my favorite is cornbread dressing.

Jan Fendley

The usual turkey and dressing but also rutabagas and red cabbage.

Jonnina Benson

Turkey and dressing with candied yams, and pumpkin pie with lots of whipped cream.

Dixie Hurd

November is National Diabetes Month

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In recognition of November being National Diabetes Month, the Oklahoma State Department of Health (OSDH) is supporting efforts to bring awareness to the impact of diabetes on Oklahoma and its economy.
Oklahoma ranks eighth in the nation for percent of adults diagnosed with diabetes. Data from the Centers for Disease Control and Prevention (CDC) indicate more than one million Oklahomans have prediabetes, and two out of three are unaware they are at risk. Without proper intervention, it is estimated that 15-30 percent of them will develop Type 2 diabetes within five years, leaving them to pay more than double their current health care costs.
“Historically, the prevalence of diabetes has been higher in Oklahoma than in the United States as a whole,” said OSDH Diabetes Program Coordinator Rita Reeves. “The most current information from the CDC indicates the prevalence of Type 2 and Type 1 are increasing among young people.”
Average medical expenses for people diagnosed with diabetes are about $13,700 per year. Patients have a higher rate of being out of the workplace and receiving disability. Nearly 95 percent of cases are Type 2, which can be prevented or delayed through a lifestyle intervention with the CDC’s National Diabetes Prevention Program. There are 21 programs in Oklahoma that offer guidance from a lifestyle coach to help set goals and adjust factors such as eating healthier, reducing stress and getting more physical activity.
Screening is the first step in preventing and managing diabetes. An online risk test to determine a person’s chance of having prediabetes is available at http://ow.ly/I9Dd30mr37O/ .
Those who have already been diagnosed with diabetes are encouraged to talk with their health care provider, and ask for a referral to an accredited self-management program, which can be found at http://ow.ly/AgvJ30mr39W .

Bringing house calls back: Dispatch comes to you

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Amy Evans and Tiffany Traxler are helping bring an exciting new health care delivery option right to your door with Dispatch Health.

story and photo by Bobby Anderson, Staff Writer

A cough. A sniffle.
You feel something coming on. But what next?
You can call your doctor and hopefully get an appointment sometime in the next couple weeks.
Or you can get in your car and head to the local urgent care clinic and wait with 20 or 30 others doing the same thing.
What if there was a better way?
That’s what Dr. Mark Prather thought in 2013 when he came up with a unique service model that would eventually become DispatchHealth.
“Really anything you can think of you would get in your car and go to urgent care for but more,” Dispatch Community Engagement Manager Tiffany Traxler said, explaining the service that has recently expanded into the metro.
DispatchHealth is bringing back the house call with a modern technology twist. DispatchHealth gives patients ways to access convenient, high-quality acute care in the comfort of their home at the time of need.
DispatchHealth is redefining the healthcare landscape as an extension of a patient’s healthcare team and offering solutions for simple to complex medical problems all from the comfort of your home.
The concept dates back to 2013 when Prather was running the emergency department in Denver for Centura Health.
“They asked Dr. Prather if he could come up with a system that could be delivered safely in the home for patients who go to the emergency room with urgent needs but not emergent,” Traxler explained. “He knew the need and he knew how to make things mobile.”
“He started going out on calls.”
Working with the ambulance service through the 911 system, Prather helped more than 400 patients in 18 months in the comfort of their own homes.
The total cost savings to the health system was more than $1 million.
But saving patients the time, expense and hassle of an ER visit was priceless.
The model has spread like wildfire to Colorado Springs, Richmond, Phoenix, Las Vegas, Houston, Oklahoma City, Tacoma, Dallas and Springfield.
Blue Cross and Blue Shield – one of Oklahoma’s largest insurers – quickly saw the value.
“Blue Cross and Blue Shield saw what we were doing and the impact we were making,” Traxler said. “For the 65-and-under patient if you have Blue Cross and Blue Shield it’s an urgent care co-pay. For 65 and up all Medicare, Medicaid and Medicare Advantage plans … we bill as an urgent care.”
For some that can mean an urgent care visit in their home for less than $50.
Services include testing such as: blood tests on-site, strep test, flu swab, urinalysis, urine cultures, stool culture, test for blood in stool, pregnancy test, lactate, 12-lead EKG, PT/INR, rapid infectious disease testing and more.
Dispatch also provides medications such as: anti-inflammatories, IV antibiotics, IV fluids, prednisone, lasix, antiemetics, flu medications, laxatives, stool softeners, heartburn prevention, glucose gel, anesthetics, migraine cocktail, antihistamines and more.
IVs can be placed and fluids begun all in your home.
Breathing treatments can also be administered.
AVOID THE BUG
Last year’s influenza outbreak was one of the worst in nearly a decade and the severity of the outbreak was extreme. In fact, The Center for Disease Control and Prevention (CDC) recorded over 20,000 positive flu tests per week at the height of the outbreak.
While most seek treatment at an emergency room (ER) or urgent care clinic, when leaving one’s home the virus can be immediately exposed to others and cause further spread of the flu. Also, ERs and clinics can easily become overwhelmed with a high number of sick patients during flu season, leading to overcrowding, lengthy wait times and even physician burnout.
Adults can infect others one day before their flu symptoms even develop and can pass on the virus up to a full week after becoming sick.
“Flu comes on very, very quickly. If it’s 2 p.m. and you realize you don’t feel well you’re not going to get into your (doctor’s office),” DispatchHealth Market Director Amy Evans said. “With flu if you can get those anti-virals within that first day or two it cuts down on the length of flu.”
“When you’re talking about the elderly population and people with compromised immune systems that 12 hours means something.” To request on-demand urgent care brought to you call 405-213-0190

Significant Women in Oklahoma Agriculture: Brenda Schulz

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Brenda Schulz of Grant, Okla. is being recognized as a Significant Woman in Oklahoma Agriculture.

story and photos by Bryan Painter

GRANT – The cliche is that time flies.
Cattlewoman Brenda Schulz, who ranches near Grant in southeastern Oklahoma’s Choctaw County, won’t argue that point.
However, two 100-year floods in 25 years is more like time sprinting rather than just marching on.
“Some of our toughest times have come from floods,” Schulz said. “Along with the wonderful aspects of having your farm and ranch in the fertile ground of the Red River comes the possibility of flooding. Curt and I have survived not one, but two, of the so called ‘100 year floods.’”
Guess what Schulz thanks for making it through those two experiences? Her cows.
Thanks to the cows
The first of those two floods Schulz is referring to came in 1990.
The May Monthly Summary that year from the Oklahoma Climatological Survey reported that the agricultural-related floods losses exceeded $57 million.
“We had leased farm ground that completely flooded,” Schulz said. “We survived, mainly due to the diversification our cattle provided. Our cattle pastures were up on the prairies around Soper, Oklahoma at this time.”
Then came the floods of 2015.
Gary McManus, state climatologist with the Oklahoma Climatological Survey, said that after being really dry for the first four months of the year, 2015’s “Super El Nino” ended up inundating far southeastern Oklahoma in May and June, and then again in November and December.
“That area near Grant in Choctaw County ended with their wettest year on record, with most of that rain falling within a select few weeks during those four months,” McManus said. “In other words, it was way too much water, concentrated into very short time frames, for the local rivers and reservoirs to handle.”
Schulz said the Red River overflowed its banks and half of their ranch flooded in May. She’s lived in Oklahoma long enough to have seen droughts turn dreams to powder. So she doesn’t curse the rains, she just respects them.
“After the water receded enough to flow within its banks again, areas north and west of us received a lot more rain and the Red River overflowed its banks once again in June,” she said. “We were not able to grow grain crops on our farm ground that year, it was too late in the season and the cows needed it for pasture. The cows have helped us survive those trying times.”
A small world
Schulz witnessed/experienced agriculture from a lot of different geographical viewpoints before landing in Oklahoma in 1984.
Not only did she grow up in North Dakota, she studied animal science at the University of Minnesota and worked with a veterinarian in Colorado where she met her husband Curt. They married in 1983 and a year later moved to Choctaw County, where his parents Delvin and Delores Schulz farmed and ranched.
“We started a beef cow herd as soon as we could,” Brenda Schulz said. “I loved being back around cows and horses. Curtis was custom farming and spraying. We rented farm ground and raised corn and soybeans.”
That was the start.
Today, 34 years after settling down in Choctaw County, they raise Angus cattle, corn, small grains, hay and pecans on 1,500 acres along the banks and in the bottoms of the Red River, south of Grant.
Schulz believes it was meant for her to live here, farm here and ranch here. Why?
Even though she was raised in North Dakota, Choctaw County is within 45 miles of her father Tom Secrest’s birthplace. Her grandfather was a sharecropper cotton farmer around Deport, Texas.
“He decided to settle his young family in east Texas when my grandparents’ wagon broke down, crossing Red River slate shoals,” she said. “These shoals are within 10 miles to the east of Stoneybroke Ranch, which is Curtis’ and my farm and ranch. It’s really a small world. I believe I have come back to my roots.”
Those roots are extending as daughter Kylee and son-in-law Keith Edge (superintendent of Boswell Schools), along with grandsons Kollin, 16, Kamden, 14 and Kolson, 12, take care of their cow/calf operation. They also help out at Stoneybroke Ranch with projects ranging from laying water lines to checking cattle.
Listen close
Cattle and horses aren’t something Schulz just tends to, she cares for them. That was evident as a child when she was around her parents breeding operation of Paints and Quarter Horses. It was evident in what she studied in college and then in the job she took working for the veterinarian. It was evident in how she gives credit to cattle bringing their operation through the floods.
It’s still evident today, especially if you listen real close during certain times of the year.
“In the spring, the cows are calving and all the babies are testing their legs, running and playing,” she said, adding that they tag and vaccinate every calf within 24 hours of birth. “I get to talk to and check the cows for new calves.”
Yes, “talk to.” What do you say?
Schulz said she would softly say something like, “You sure had a pretty baby, didn’t you? Good Mama!”
It is an enjoyable experience like that, that makes time fly at a comfortable pace.

SYNERGY HomeCare

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Weama Kassem, CEO and President of SYNERGY HomeCare with Jeff Aynes who recently joined the SYNERGY Home Care Team as their Director of Sales and Marketing.

Expanding and strengthening their team and service

SYNERGY HomeCare proudly opened their doors over 5 years ago in Edmond, Oklahoma. Weama Kassem, CEO and President of SYNERGY HomeCare, has always dreamt of having a business that centered around caring for others; specifically, our aging community. Weama has been fortunate enough to attract a team of professionals with the same heartfelt drive and talent. The people Weama has assembled have accomplished some incredible things by always putting their clients’ needs and happiness first. The SYNERGY HomeCare team always refers to each other as “SYNERGY Family” and they work together to create an atmosphere of care and respect for each other and for their clients and families.
Weama opened her second office in December 2016 in Norman, Oklahoma. This enabled the company to reach and connect a larger clientele and reaching beyond Edmond and Oklahoma City. One of the most essential guidelines in opening the new location has been to duplicate their high standard of care. SYNERGY HomeCare does not use contracted caregivers, all are employees who must completed in-house training, along with continued monthly and quarterly training programs. This ensures the caregivers are not only qualified, but it strengthens the support and bonds within the company itself. Each caregiver is a Certified Nursing Assistant and/or a Certified Home Health Aide. They are each insured and bonded by SYNERGY HomeCare and strive to provide excellent care and support to both clients and their families.
SYNERGY HomeCare is very pleased to announce that Jeff Aynes has joined the SYNERGY Home Care Team as our Director of Sales and Marketing. Jeff has been a strong advocate for health care in Oklahoma for many years and will make a great leader on our team. Jeff is a father of two beautiful ladies and grandfather of two beautiful girls. He went to the University of Central Oklahoma and Oklahoma State University where he studied Marketing, Public Relations, and Broadcasting. Jeff is a Past President of Marketing Plus for Healthcare and currently serves as Secretary. He is currently serving as President of the Northside Marketing Alliance, as well as, Secretary. He has served in the community for many years as a member of the Shriner’s, Scottish Rite, Eastern Star, Amaranth, and Masons where he is a Past Master. He has been volunteering with Muscular Dystrophy, Cerebral Palsy Association, and Make Promises Happen Camp for over 25 years. His passion outside of Sales and Marketing is music. He has owned Jammin’ Jeff Entertainment for over 25 years and has performed over 1,800 events. Jeff joins the SYNERGY staff from AllianceHealth Midwest where he served as Director of Marketing for the Behavioral Health Program. Prior to going to AHM, Jeff served for over 5 years at Absolute Senior Care of Oklahoma City and A Premier Senior Home Care of Tulsa as their Director. We are beyond thrilled and honored that Jeff has chosen to join our team and know he is truly a valuable asset that will provide wonderful support to our growing company.
Together, Weama and Jeff, will be able to provide assistance to our aging community, education to our referral partners, knowledge to our team of growing caregivers, and a bright and smiling face to see each time you encounter them. Serving people is what SYNERGY HomeCare does every day and it is truly the drive and passion of both Weama and Jeff. With over 100 caregivers and five years in business, the SYNERGY HomeCare team stands ready to answer specific questions about care.
Whether you are a senior living on your own, with an aging spouse, or you have an aging parent – there are some key things to keep in mind when selecting a home care company. First, is the home care company licensed in the state? Companies are reviewed annually to determine their eligibility, and this is a perfectly normal question to ask a potential company. Ask to see a copy of their business license. Second, ask if the caregivers are employed by the company instead of being contract labor employees. It may seem beneficial to contract our work, but actually you can face many liability and scheduling issues down the road. Ask the provider to include client AND their family members in developing the plan of care. SYNERGY HomeCare has full-time RNS on staff to specifically build a plan of care for each new client and they spend the time you need to sort out every little detail. Lastly, ask for a list of references so you can check in on who you are considering to employ! We are all use to providing references when applying for a job. SYNERGY HomeCare is happy to answer questions like these anytime.
SYNERGY HomeCare is a group of Oklahomans that you can trust. Weama, Jeff, and the whole team are honored to provide care to this amazing community and welcome your call anytime, day or night!

SYNERGY HomeCare is located at 13720 N Bryant Ave. Edmond, OK 73013 405-254-3046
www.synergyhomecareedmond.com

 

Centerpiece to be added to Oklahoma Memorial

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With the installation of a twenty-four foot Blue Light Centerpiece this week, the Oklahoma Law Enforcement Memorial added the final piece to the newly repaired and renovated memorial plaza. The Oklahoma Law Enforcement Memorial is the oldest state law enforcement memorial in the United States, dedicated on May 15, 1969. A few years ago it was discovered the memorial was sinking after almost fifty years of withstanding Oklahoma weather and rain water flowing over and apparently under it. Donations were made and the work to repair and renovate the memorial started on December 15th of last year when the memorial stones were taken up and stored. The renovated memorial was for the most part completed and was rededicated during the Fiftieth Annual Memorial Service on May 18th of this year. The center piece was the only part not ready by the service.
This Sunday, November 4th at 5:30 p.m. during the Oklahoma Chapter of the Concerns of Police Survivor’s Annual Blue Light Ceremony the perpetual Blue Light Center Piece will officially be turned on as a constant reminder of the service and sacrifices of our law enforcement officers. The memorial is located on the west grounds of the Oklahoma Department of Public Safety Headquarters, 3600 M. L. King Avenue in Oklahoma City. The public is encouraged to attend.
The names of over eight hundred officers who have died in the line of duty in Oklahoma, both before and after statehood, are engraved on the memorial. See the memorial’s web site at www.oklemem.com for more information on the memorial and Oklahoma’s fallen officers.

Former OPEA worker finds hope and new purpose on cancer journey

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Just a few years ago Nancy Hughes could lift mountains of paperwork, rearrange office furniture and stand on her feet for hours at a time. As executive assistant at the Oklahoma Public Employees Association, the petite fiery redhead put in long hours at her job helping give state employees a voice in government.
Back in 2003, Nancy learned she had breast cancer. She underwent a mastectomy, rounds of chemotherapy and the cancer went into remission. In 2014, however, it came back with a vengeance.
“I first noticed something was wrong when I bent over to pick up something,” she said. “I felt something pull, and had trouble walking. After about a month I went to a chiropractor about my back. He took x-rays, and they showed either severe osteoporosis or the cancer was back and in my bones.”
A trip to her oncologist revealed the cancer had indeed spread.
“I had no idea breast cancer could come back like that,” Nancy said. “This time I was scared. During the time I was cancer-free, I had been participating in the Oklahoma American Cancer Society’s Making Strides Against Breast Cancer walk, and the Relay For Life. I liked being a beacon of hope for others that this disease could be beat.”
So once again she began the treatments, hoping for a positive result.
“This time it was radiation to my hip, spine and right arm,” she said. “It helped with the pain I was having but I do not remember much about that time. I lost control of my body functions, could barely walk and did not eat much. My employer offered me six months of leave to keep my insurance and then social security kicked in, so I took it. I could no longer do my job and was actually a liability to them.”
More than four years after her cancer re-occurrence, the disease has been relentless.
“When it came back, it had spread throughout my bones,” Nancy said. “My right arm fractured, and I had to wear a brace for two years to keep it stable. The bone was almost clear and looked like Swiss cheese. I had the option of getting surgery to put a rod in to stabilize it, but there was a possibility I could lose all the use of that arm. Even having limited use was better than losing it all, so I chose to not have the surgery.”
Using the services offered at the Oklahoma American Cancer Society has been a godsend, Nancy says. The organization offers wigs, scarves, and turbans, all free of charge to cancer patients. They also provide free rides to and from treatment in the Road to Recovery Program.
“Helping people like Nancy is at the heart of what we do every day,” said Jennifer Redman, OKACS program manager. “Not only do we have an entire wig room, but transportation is consistently named as one of the top needs for cancer patients. Our volunteer driver program ensures patients complete their treatment and we can increase the number of cancer survivors. We always need more volunteer drivers and have our own fleet of vehicles. So if you have some time to volunteer, we can always use the help.”
While each day is a struggle, Nancy refuses to let the disease dampen the positive attitude that has carried her through life.
“When I wake up every morning, it is a gift of life,” she said. “I could choose to wallow in pity and feel sorry for myself, but what does that do? I choose to enjoy each day and hope a cure will be found in my lifetime. Sometimes the dark side will come through. Like a day or so ago I realized once my hair is gone this time, I will most likely be bald the rest of my life. That sucks. But I must play the cards I am dealt, so I will save a few bucks on shampoo and conditioner! It’s all about re-framing the negatives and finding the positives.”
Nancy says her family is her foundation. Her husband Mike, their two daughters and four grandsons all pitch in to make life as normal as possible. And throughout her journey, she continually finds new ways to reinvent herself and help others.
“Sharing my story with the Oklahoma American Cancer Society and others is so important,” Nancy said. “I want everyone to know the big ‘C’ word is not always a death sentence. It does not always return like it did for me. Stay hopeful, happy and enjoy what you can. Don’t dwell on the horrible parts, just try to look for the good in everything. Believe me, it is there.”

INTEGRIS Deaconess Announces New President

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Rex Van Meter, president of INTEGRIS Deaconess.

INTEGRIS assumed operations of Deaconess Hospital and its affiliated family care clinics at midnight, Oct. 1.
Rex Van Meter is the newly named president of INTEGRIS Deaconess, as it is now called. The hospital is considered a campus under the INTEGRIS Baptist Medical Center umbrella.
Van Meter has been a part of executive leadership at INTEGRIS since 2001. He joined as vice president of finance at INTEGRIS Blackwell Hospital and was promoted to president there four years later. In 2012, he was named president of INTEGRIS Canadian Valley Hospital, and has led that facility to successive year-over-year record performances. Van Meter earned a bachelor of accounting from Northwestern Oklahoma State University and a master of health care administration from Trinity University.

A Doctor is Born: Physician Partners with Baby He Delivered 33 Years Ago

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David Kallenberger, M.D., and Crysten Cheatwood, D.O., are physician partners who practice obstetrics and gynecology at INTEGRIS Baptist Medical Center in Oklahoma City. But what makes their partnership so extraordinary, is that they share a professional and personal bond very few will ever experience.
Cheatwood has known Kallenberger her entire life – literally. In fact, he was the one who physically brought her into this world, as the physician who delivered her as a newborn. “I could not have imagined 33 years ago when I delivered Crysten that she one day would be working with me,” admits Kallenberger. “This is indeed a full circle moment for me.”
“He was my grandmother’s OBGYN then he was my mother’s doctor, so I was familiar with his name and reputation very early on,” says Cheatwood. “I can remember being young enough that my mom would make me stay in the changing room during her exams.”
“I also saw Dr. Kallenberger at all of my mom’s prenatal visits when she was pregnant with my sister. He could tell I was curious so he was always asking me questions and volunteering information regarding my mom’s pregnancy. He made it a point to include me in all of the conversations.”
Kallenberger was equally impressed with young Cheatwood. “She made an impression on me at a very young age. She would ask questions that were very inquisitive and profound for a 12 year old. She was always probing for more information.”
Cheatwood remembers being fascinated by medicine and almost obsessed with her mother’s pregnancy. “I attended every doctor’s appointment. I even read the “What to Expect When You’re Expecting” book with my mom. I was completely invested.”
The day her sister, Hannah, was born, Cheatwood was in the delivery room. That is when her fate was sealed. “I was standing with my dad at the head of the bed when Dr. K walked into the room. He said, ‘Crissy… do you want to deliver this baby?’ Wondering if he was actually serious, I nodded my head yes. He said, ‘go over to the sink and wash up to your elbows, we’ll help you with some gloves.’ He told me where to put my hands and then put his hands over mine. And then he talked me through the whole thing!”
From that moment on, Cheatwood knew exactly what she wanted to be when she grew up. She wanted to be an OBGYN just like her newfound idol, “Dr. K.”
“She was a natural,” says Kallenberger recalling her sister’s birth. “She was not shocked, she just jumped right in without question and working with my hands literally delivered her sister. It was an amazing experience. In a way, a doctor was also born that day.”
Cheatwood shadowed Kallenberger several times during high school, college and medical school. She did a couple rotations with him again during her residency training. Now, with her medical degree in hand, she is Kallenberger’s newest partner.
Cheatwood remembers the moment he made her the offer to come work with him. “I was speechless initially, again wondering if he was actually serious. And then I nodded my head yes. It was wildly similar to the reaction I had when he asked if I wanted to deliver my sister all those years ago.”
“I feel like I’ve been shadowing him for 22 years,” laughs Cheatwood. “He has afforded me a tremendous amount of encouragement and exposure. He is a phenomenal teacher and an exceptional physician. I hope to continue following in his footsteps.”
Kallenberger has no doubt that Cheatwood will tread her own path, and is beyond proud of the physician she has become. “It is somewhat surreal working with her but I have worked with her so many times over the years as a mentor or as faculty that it feels natural.”
“I don’t know that this is necessarily a passing of the torch,” continues Kallenberger. “But I do want to groom her to be able to take over my practice one day when I decide to retire. It is comforting to know that someone with her compassion and skill set will be available to take care of my patients in the same way that I have tried to do over the last 42 years.”
Kallenberger estimates that he has delivered more than 15,000 babies in his lifetime. While he says some of them have grown up to be doctors, he says Cheatwood is the first he’s ever had the privilege to call partner.
“The transition we’ve made from student/teacher to colleagues has been interesting and entertaining,” Cheatwood jokes. “A few days after I started here, he told me to call him David now. I still can’t do it without laughing a little bit. I’ve heard people talk about their “work wife” or “work husband.” We definitely have a “work father/daughter” relationship. I have so much respect for him. He’s been such an advocate for me as a new physician. Even though I’m working beside him now, I will always look up to him.”

New findings cast light on lymphatic system, key player in human health

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Oklahoma Medical Research Foundation scientist Satish Srinivasan, Ph.D.

Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
The lymphatic system is a network of vessels and lymph nodes that spans the entire body. It is critical for good health and for the body to function properly. Defects in lymphatic vessels cause lymphedema, a disease characterized by dramatic and painful swelling in the limbs that often leads to infections.
Lymphedema can result from congenital mutations, surgery, radiation treatment for cancer or infection, and there is currently no cure. In addition to lymphedema, defects in the lymphatic system have been linked to a wide range of health consequences: cancer, atherosclerosis, Alzheimer’s disease and obesity.
Sathish Srinivasan, Ph.D., and Boksik Cha, Ph.D., at OMRF previously discovered that a particular pathway—known as the Wnt signaling pathway—regulates the development of the human lymphatic vascular system. In new research, published in the journal Cell Reports, they’ve found “the nuts and bolts of this important pathway.”
“We have identified the signaling molecules that activate this pathway,” said Srinivasan. “We also have learned which cells produce the signaling molecules, how they are sensed by the cells and how they are used in lymphatic development.”
Srinivasan was recruited to OMRF from St. Jude’s Children’s Research Hospital in 2013. His lab at OMRF has already identified several target genes for lymphedema. Srinivasan said that, after further study, this new information could eventually help researchers develop better therapeutic options for lymphedema and associated disorders.
“This signaling pathway has proved difficult to study, because it is complex and so little is known about how it functions normally, let alone when it goes wrong,” said Srinivasan. “Wnt signaling is aggravated and increased in breast cancer and colon cancer, but it is deregulated in diseases like Alzheimer’s and lymphedema.”
Srinivasan said drug companies are interested in finding molecules that can be targeted, either to promote or inhibit Wnt signaling, depending on the disease. “Our goal is to find whether such drugs could be used to treat humans with lymphedema and see if their disease can be managed, made less severe or even cured,” he said.
Other OMRF researchers who contributed to this research were Xin Geng, Ph.D., Riaj Mahamud, Lijuan Chen and Lorin Olson, Ph.D.

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