Thursday, January 29, 2026

Centerpiece to be added to Oklahoma Memorial

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With the installation of a twenty-four foot Blue Light Centerpiece this week, the Oklahoma Law Enforcement Memorial added the final piece to the newly repaired and renovated memorial plaza. The Oklahoma Law Enforcement Memorial is the oldest state law enforcement memorial in the United States, dedicated on May 15, 1969. A few years ago it was discovered the memorial was sinking after almost fifty years of withstanding Oklahoma weather and rain water flowing over and apparently under it. Donations were made and the work to repair and renovate the memorial started on December 15th of last year when the memorial stones were taken up and stored. The renovated memorial was for the most part completed and was rededicated during the Fiftieth Annual Memorial Service on May 18th of this year. The center piece was the only part not ready by the service.
This Sunday, November 4th at 5:30 p.m. during the Oklahoma Chapter of the Concerns of Police Survivor’s Annual Blue Light Ceremony the perpetual Blue Light Center Piece will officially be turned on as a constant reminder of the service and sacrifices of our law enforcement officers. The memorial is located on the west grounds of the Oklahoma Department of Public Safety Headquarters, 3600 M. L. King Avenue in Oklahoma City. The public is encouraged to attend.
The names of over eight hundred officers who have died in the line of duty in Oklahoma, both before and after statehood, are engraved on the memorial. See the memorial’s web site at www.oklemem.com for more information on the memorial and Oklahoma’s fallen officers.

Significant Women in Oklahoma Agriculture: Brenda Schulz

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Brenda Schulz of Grant, Okla. is being recognized as a Significant Woman in Oklahoma Agriculture.

story and photos by Bryan Painter

GRANT – The cliche is that time flies.
Cattlewoman Brenda Schulz, who ranches near Grant in southeastern Oklahoma’s Choctaw County, won’t argue that point.
However, two 100-year floods in 25 years is more like time sprinting rather than just marching on.
“Some of our toughest times have come from floods,” Schulz said. “Along with the wonderful aspects of having your farm and ranch in the fertile ground of the Red River comes the possibility of flooding. Curt and I have survived not one, but two, of the so called ‘100 year floods.’”
Guess what Schulz thanks for making it through those two experiences? Her cows.
Thanks to the cows
The first of those two floods Schulz is referring to came in 1990.
The May Monthly Summary that year from the Oklahoma Climatological Survey reported that the agricultural-related floods losses exceeded $57 million.
“We had leased farm ground that completely flooded,” Schulz said. “We survived, mainly due to the diversification our cattle provided. Our cattle pastures were up on the prairies around Soper, Oklahoma at this time.”
Then came the floods of 2015.
Gary McManus, state climatologist with the Oklahoma Climatological Survey, said that after being really dry for the first four months of the year, 2015’s “Super El Nino” ended up inundating far southeastern Oklahoma in May and June, and then again in November and December.
“That area near Grant in Choctaw County ended with their wettest year on record, with most of that rain falling within a select few weeks during those four months,” McManus said. “In other words, it was way too much water, concentrated into very short time frames, for the local rivers and reservoirs to handle.”
Schulz said the Red River overflowed its banks and half of their ranch flooded in May. She’s lived in Oklahoma long enough to have seen droughts turn dreams to powder. So she doesn’t curse the rains, she just respects them.
“After the water receded enough to flow within its banks again, areas north and west of us received a lot more rain and the Red River overflowed its banks once again in June,” she said. “We were not able to grow grain crops on our farm ground that year, it was too late in the season and the cows needed it for pasture. The cows have helped us survive those trying times.”
A small world
Schulz witnessed/experienced agriculture from a lot of different geographical viewpoints before landing in Oklahoma in 1984.
Not only did she grow up in North Dakota, she studied animal science at the University of Minnesota and worked with a veterinarian in Colorado where she met her husband Curt. They married in 1983 and a year later moved to Choctaw County, where his parents Delvin and Delores Schulz farmed and ranched.
“We started a beef cow herd as soon as we could,” Brenda Schulz said. “I loved being back around cows and horses. Curtis was custom farming and spraying. We rented farm ground and raised corn and soybeans.”
That was the start.
Today, 34 years after settling down in Choctaw County, they raise Angus cattle, corn, small grains, hay and pecans on 1,500 acres along the banks and in the bottoms of the Red River, south of Grant.
Schulz believes it was meant for her to live here, farm here and ranch here. Why?
Even though she was raised in North Dakota, Choctaw County is within 45 miles of her father Tom Secrest’s birthplace. Her grandfather was a sharecropper cotton farmer around Deport, Texas.
“He decided to settle his young family in east Texas when my grandparents’ wagon broke down, crossing Red River slate shoals,” she said. “These shoals are within 10 miles to the east of Stoneybroke Ranch, which is Curtis’ and my farm and ranch. It’s really a small world. I believe I have come back to my roots.”
Those roots are extending as daughter Kylee and son-in-law Keith Edge (superintendent of Boswell Schools), along with grandsons Kollin, 16, Kamden, 14 and Kolson, 12, take care of their cow/calf operation. They also help out at Stoneybroke Ranch with projects ranging from laying water lines to checking cattle.
Listen close
Cattle and horses aren’t something Schulz just tends to, she cares for them. That was evident as a child when she was around her parents breeding operation of Paints and Quarter Horses. It was evident in what she studied in college and then in the job she took working for the veterinarian. It was evident in how she gives credit to cattle bringing their operation through the floods.
It’s still evident today, especially if you listen real close during certain times of the year.
“In the spring, the cows are calving and all the babies are testing their legs, running and playing,” she said, adding that they tag and vaccinate every calf within 24 hours of birth. “I get to talk to and check the cows for new calves.”
Yes, “talk to.” What do you say?
Schulz said she would softly say something like, “You sure had a pretty baby, didn’t you? Good Mama!”
It is an enjoyable experience like that, that makes time fly at a comfortable pace.

Soul searching: Seniors publish new book

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A group of senior friends published a new book that takes a look at the undercurrent behind today’s political climate.

by Bobby Anderson, Staff Writer

A sociologist, a psychologist and a benedictine nun walk into a room.
Sounds like the beginnings of a good joke.
But for John Karlin, PhD, those are just a few of the cast of characters that helped create his new book: Fear, Religion, Politics: Well I’ll Be Darn!
Karlin spent the last year of his life writing this book that takes a look at the intertwining of three things deeply personal to Americans.
“It was incredible in the sense that how much insight humans have but not realize it,” Karlin said. “In researching this I kept seeing these little lights in other people’s works.”
Karlin was aided by Dr. Melvyn Preisz, Rhonda Bell, Judy Martin, Marsha McMillin, Gerry Lantagne and others in developing his second book. Each brought their own unique talents.
Preisz is a local clinical psychologist who befriended Karlin years ago.
“I agree with Dr. Karlin’s timely and insightful assessments of this unprecedented crisis,” Preisz said. “From my own psychological viewpoint, these enemies of our individual freedoms collude to divide and conquer the good within us, and to continue to attack our personal conscience from a buffet of lies.”
Karlin stresses he has no political motives with this book.
His wish for what readers walk away with is simple.
“Simply an understanding of those undercurrents, a complete, full, intense understanding of … what’s actually happening underneath the surface,” Karlin said. “I just expose those undercurrents, that was my whole concern. I write from a sociological perspective.”
“I’m not the only one who has picked up on this. What I found is pieces of those themes in many, many other works.”
Karlin cites some 120 references in his work, that he says was a labor love performed with dear friends.
“Our intent was to give seniors out there a message that you can do stuff like this. You’re never too old,” the 72-year-old Karlin said. ”Don’t just sit, you’re capable of doing stuff.”
More than 20 years of Karlin’s life have been spent in teaching, largely at Northwestern Oklahoma State in Alva, Oklahoma City University and Phillips University.
While teaching sociology and criminal justice at OCU, Karlin begin his friendship with Preisz.
Preisz introduced him to Lantagne, who introduced Martin, a former Benedictine nun and things began falling into place.
“It was just friends introducing friends,” Karlin said. “It was basically happenstance then realized ‘Gosh, look at all this talent.”
The motives were simple.
“I just didn’t like the way things were going in this country especially politically and socially in terms of the turmoil and discontent,” Karlin said. “I thought there had to be something underneath that. As a sociologist you always know that what’s on the surface isn’t always the whole story.”
“Sometimes in our culture there are some very deep undercurrents that help explain.”
Karlin recalled attending Louisiana State University for his doctorate. A conversation with an old fisherman came to mind.
The fisherman pointed to the Mississippi River and told Karlin to watch it closely.
“It’s just real slow, old man river kind of thing but underneath that is just incredible turmoil,” Karlin said. “The Mississippi in spots is almost a mile deep and a lot of people don’t realize that because the undercurrent is cutting it.”
“There are literally complete trees down there. That’s the way culture and society can be.”
That got Karlin thinking about what’s underneath today’s politics and headlines.
“What’s under that is not good,” he said.
Karlin’s book flows through three sequences with the first being our innate fear of death and how we view our own mortality.
“And how that came to actually produce the phenomena we call religion in society,” Karlin said. “Any religion, it doesn’t matter what it is, came from the fear of death because religion was a way to escape that tension and fear.”
The second sequence evaluated Christianity and the life of Jesus Christ.
“I looked at what (Jesus Christ) was actually trying to accomplish in his own time and he was trying to accomplish something,” Karlin said. “You’ll find that as somewhat of a shocker.”
The third sequence takes things into the political realm.
“That’s where the dream goes awry because a big chunk of our Christian community want to blend religion and politics to the point where they are no longer distinguishable and that’s not good,” Karlin said.
“That’s what has created most of the problems you see in society today. Basically, it’s the drive towards theocracy.”
Karlin’s book is now available on Amazon. He will do a benefit book signing for the Peace House at the Peace Festival at the Civic Center Music Hall November 10 from 10 a.m. to 4 p.m.
The Peace House will get $5 for every book sold.

SAVVY SENIOR: How to Choose a Good Estate Sale Company

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Dear Savvy Senior, Can you provide some tips on how to choose a good estate sale company who can sell all the leftover items in my mother’s house?  Inquiring Daughter

Dear Inquiring,
The estate sale business has become a huge industry over the past decade. There are roughly 22,000 estate sale companies that currently operate in the U.S., up nearly 60 percent from just 10 years ago. But not all estate sale companies are alike.
Unlike appraisal, auction and real estate companies, estate sale operators are largely unregulated, with no licensing or standard educational requirements. That leaves the door open for inexperienced, unethical or even illegal operators. Therefore, it’s up to you to decipher a good reputable company from a bad one. Here are some tips to help you choose.
Make a list: Start by asking friends, your real estate agent or attorney for recommendations. You can also search online. Websites like EstateSales.net and EstateSales.org let you find estate sale companies in your area.
Check their reviews: After you find a few companies, check them out on the Better Business Bureau (BBB.org), Angie’s List (AngiesList.com), Yelp (Yelp.com) and other online review sites to eliminate ones with legitimately negative reviews.
Call some companies: Once you identify some estate sale companies, select a few to interview over the phone. Ask them how long they’ve been in business and how many estate sales they conduct each month. Also find out about their staff, the services they provide, if they are insured and bonded and if they charge a flat fee or commission. The national average commission for an estate sale is around 35 percent, but commissions vary by city and region.
You may also want to ask them about visiting their next sale to get a better feel for how they operate. And be sure to get a list of references of their past clients and call them.
Schedule appointments: Set up two or three face-to-face interviews with the companies you felt provided you with satisfactory answers during the phone interviews.
During their visit, show the estate liquidator through the property. Point out any items that will not be included in the sale, and if you have any items where price is a concern, discuss it with them at that time. Many estate companies will give you a quote, after a quick walk through the home.
You also need to ask about their pricing (how do they research prices and is every item priced), how they track what items sell for, what credit cards do they accept, and how and where will they promote and market your sale. EstateSales.net is a leading site used to advertise sales, so check advertising approaches there.
Additionally, ask how many days will it take them to set up for the sale, how long will the sale last, and will they take care of getting any necessary permits to have the sale.
You also need to find out how and when you will be paid, and what types of services they provide when the sale is over. Will they clean up the house and dispose of the unsold items, and is there’s an extra charge for that? Also, make sure you get a copy of their contract and review it carefully before you sign it.
For more information on choosing an estate sale company, see National Estate Sales Association online guide at NESA-USA.com, and click on “Consumer Education” then on “Find the Right Company.

Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of “The Savvy Senior” book.

INTEGRIS Deaconess Announces New President

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Rex Van Meter, president of INTEGRIS Deaconess.

INTEGRIS assumed operations of Deaconess Hospital and its affiliated family care clinics at midnight, Oct. 1.
Rex Van Meter is the newly named president of INTEGRIS Deaconess, as it is now called. The hospital is considered a campus under the INTEGRIS Baptist Medical Center umbrella.
Van Meter has been a part of executive leadership at INTEGRIS since 2001. He joined as vice president of finance at INTEGRIS Blackwell Hospital and was promoted to president there four years later. In 2012, he was named president of INTEGRIS Canadian Valley Hospital, and has led that facility to successive year-over-year record performances. Van Meter earned a bachelor of accounting from Northwestern Oklahoma State University and a master of health care administration from Trinity University.

Rhoades Named Oklahoma State Department of Health Chief Medical Officer

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Dr. Edd Rhoades as Chief Medical Officer.

Oklahoma State Department of Health (OSDH) Interim Commissioner Tom Bates has appointed Dr. Edd Rhoades as Chief Medical Officer for the agency. Dr. Rhoades has been with the agency for 40 years and is currently serving as the Medical Director for Family Health Services.
“Dr. Rhoades has served the state and this agency with integrity in a number of key positions over the years and it is appropriate that he should be the first person to fill this important role,” said Commissioner Bates. “The establishment of a Chief Medical Officer aligns with the public health structure of many other states and will provide guidance to our core mission.”
The Oklahoma State Board of Health approved creation of the position at their Sept. 14 meeting, following a recommendation that was included in a corrective action plan provided to the legislature in January. The Chief Medical Officer will advise agency leadership on medical and public health issues and provide medical oversight and consultation to agency service areas and county health departments. Under the current organizational structure, the Office of the Commissioner continues to focus on improving the financial operation and organization of the agency to ensure efficient delivery of core services.
A graduate of the University of Oklahoma School of Medicine, Dr. Rhoades also holds a Masters of Public Health in Health Administration from the University of Oklahoma College of Public Health. He is a Diplomate of the American Board of Pediatrics and has received numerous awards for his work in maternal and child health and environmental protection. Among his honors are the Joan K. Leavitt, M.D. Award from the Oklahoma Public Health Association and the Mike Synar Environmental Excellence Award.
“I’m looking forward to working with Commissioner Bates and the senior leadership team to provide guidance for the agency as we continue to focus on issues that will improve the health of all Oklahomans,” said Dr. Rhoades. “I’m honored to have this opportunity to share my experiences and promote the great work being done by all of our public health professionals.

Social Security Announces 2.8 Percent Benefit Increase for 2019

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Social Security and Supplemental Security Income (SSI) benefits for more than 67 million Americans will increase 2.8 percent in 2019, the Social Security Administration announced today.
The 2.8 percent cost-of-living adjustment (COLA) will begin with benefits payable to more than 62 million Social Security beneficiaries in January 2019. Increased payments to more than 8 million SSI beneficiaries will begin on December 31, 2018. (Note: some people receive both Social Security and SSI benefits). The Social Security Act ties the annual COLA to the increase in the Consumer Price Index as determined by the Department of Labor’s Bureau of Labor Statistics.
Some other adjustments that take effect in January of each year are based on the increase in average wages. Based on that increase, the maximum amount of earnings subject to the Social Security tax (taxable maximum) will increase to $132,900 from $128,400.
Social Security and SSI beneficiaries are normally notified by mail in early December about their new benefit amount. This year, for the first time, most people who receive Social Security payments will be able to view their COLA notice online through their my Social Security account. People may create or access their my Social Security account online at www.socialsecurity.gov/myaccount.
Information about Medicare changes for 2019, when announced, will be available at www.medicare.gov. For Social Security beneficiaries receiving Medicare, Social Security will not be able to compute their new benefit amount until after the Medicare premium amounts for 2019 are announced. Final 2019 benefit amounts will be communicated to beneficiaries in December through the mailed COLA notice and my Social Security’s Message Center.
The Social Security Act provides for how the COLA is calculated. To read more, please visit www.socialsecurity.gov/cola.

SYNERGY HomeCare

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Weama Kassem, CEO and President of SYNERGY HomeCare with Jeff Aynes who recently joined the SYNERGY Home Care Team as their Director of Sales and Marketing.

Expanding and strengthening their team and service

SYNERGY HomeCare proudly opened their doors over 5 years ago in Edmond, Oklahoma. Weama Kassem, CEO and President of SYNERGY HomeCare, has always dreamt of having a business that centered around caring for others; specifically, our aging community. Weama has been fortunate enough to attract a team of professionals with the same heartfelt drive and talent. The people Weama has assembled have accomplished some incredible things by always putting their clients’ needs and happiness first. The SYNERGY HomeCare team always refers to each other as “SYNERGY Family” and they work together to create an atmosphere of care and respect for each other and for their clients and families.
Weama opened her second office in December 2016 in Norman, Oklahoma. This enabled the company to reach and connect a larger clientele and reaching beyond Edmond and Oklahoma City. One of the most essential guidelines in opening the new location has been to duplicate their high standard of care. SYNERGY HomeCare does not use contracted caregivers, all are employees who must completed in-house training, along with continued monthly and quarterly training programs. This ensures the caregivers are not only qualified, but it strengthens the support and bonds within the company itself. Each caregiver is a Certified Nursing Assistant and/or a Certified Home Health Aide. They are each insured and bonded by SYNERGY HomeCare and strive to provide excellent care and support to both clients and their families.
SYNERGY HomeCare is very pleased to announce that Jeff Aynes has joined the SYNERGY Home Care Team as our Director of Sales and Marketing. Jeff has been a strong advocate for health care in Oklahoma for many years and will make a great leader on our team. Jeff is a father of two beautiful ladies and grandfather of two beautiful girls. He went to the University of Central Oklahoma and Oklahoma State University where he studied Marketing, Public Relations, and Broadcasting. Jeff is a Past President of Marketing Plus for Healthcare and currently serves as Secretary. He is currently serving as President of the Northside Marketing Alliance, as well as, Secretary. He has served in the community for many years as a member of the Shriner’s, Scottish Rite, Eastern Star, Amaranth, and Masons where he is a Past Master. He has been volunteering with Muscular Dystrophy, Cerebral Palsy Association, and Make Promises Happen Camp for over 25 years. His passion outside of Sales and Marketing is music. He has owned Jammin’ Jeff Entertainment for over 25 years and has performed over 1,800 events. Jeff joins the SYNERGY staff from AllianceHealth Midwest where he served as Director of Marketing for the Behavioral Health Program. Prior to going to AHM, Jeff served for over 5 years at Absolute Senior Care of Oklahoma City and A Premier Senior Home Care of Tulsa as their Director. We are beyond thrilled and honored that Jeff has chosen to join our team and know he is truly a valuable asset that will provide wonderful support to our growing company.
Together, Weama and Jeff, will be able to provide assistance to our aging community, education to our referral partners, knowledge to our team of growing caregivers, and a bright and smiling face to see each time you encounter them. Serving people is what SYNERGY HomeCare does every day and it is truly the drive and passion of both Weama and Jeff. With over 100 caregivers and five years in business, the SYNERGY HomeCare team stands ready to answer specific questions about care.
Whether you are a senior living on your own, with an aging spouse, or you have an aging parent – there are some key things to keep in mind when selecting a home care company. First, is the home care company licensed in the state? Companies are reviewed annually to determine their eligibility, and this is a perfectly normal question to ask a potential company. Ask to see a copy of their business license. Second, ask if the caregivers are employed by the company instead of being contract labor employees. It may seem beneficial to contract our work, but actually you can face many liability and scheduling issues down the road. Ask the provider to include client AND their family members in developing the plan of care. SYNERGY HomeCare has full-time RNS on staff to specifically build a plan of care for each new client and they spend the time you need to sort out every little detail. Lastly, ask for a list of references so you can check in on who you are considering to employ! We are all use to providing references when applying for a job. SYNERGY HomeCare is happy to answer questions like these anytime.
SYNERGY HomeCare is a group of Oklahomans that you can trust. Weama, Jeff, and the whole team are honored to provide care to this amazing community and welcome your call anytime, day or night!

SYNERGY HomeCare is located at 13720 N Bryant Ave. Edmond, OK 73013 405-254-3046
www.synergyhomecareedmond.com

 

A Doctor is Born: Physician Partners with Baby He Delivered 33 Years Ago

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David Kallenberger, M.D., and Crysten Cheatwood, D.O., are physician partners who practice obstetrics and gynecology at INTEGRIS Baptist Medical Center in Oklahoma City. But what makes their partnership so extraordinary, is that they share a professional and personal bond very few will ever experience.
Cheatwood has known Kallenberger her entire life – literally. In fact, he was the one who physically brought her into this world, as the physician who delivered her as a newborn. “I could not have imagined 33 years ago when I delivered Crysten that she one day would be working with me,” admits Kallenberger. “This is indeed a full circle moment for me.”
“He was my grandmother’s OBGYN then he was my mother’s doctor, so I was familiar with his name and reputation very early on,” says Cheatwood. “I can remember being young enough that my mom would make me stay in the changing room during her exams.”
“I also saw Dr. Kallenberger at all of my mom’s prenatal visits when she was pregnant with my sister. He could tell I was curious so he was always asking me questions and volunteering information regarding my mom’s pregnancy. He made it a point to include me in all of the conversations.”
Kallenberger was equally impressed with young Cheatwood. “She made an impression on me at a very young age. She would ask questions that were very inquisitive and profound for a 12 year old. She was always probing for more information.”
Cheatwood remembers being fascinated by medicine and almost obsessed with her mother’s pregnancy. “I attended every doctor’s appointment. I even read the “What to Expect When You’re Expecting” book with my mom. I was completely invested.”
The day her sister, Hannah, was born, Cheatwood was in the delivery room. That is when her fate was sealed. “I was standing with my dad at the head of the bed when Dr. K walked into the room. He said, ‘Crissy… do you want to deliver this baby?’ Wondering if he was actually serious, I nodded my head yes. He said, ‘go over to the sink and wash up to your elbows, we’ll help you with some gloves.’ He told me where to put my hands and then put his hands over mine. And then he talked me through the whole thing!”
From that moment on, Cheatwood knew exactly what she wanted to be when she grew up. She wanted to be an OBGYN just like her newfound idol, “Dr. K.”
“She was a natural,” says Kallenberger recalling her sister’s birth. “She was not shocked, she just jumped right in without question and working with my hands literally delivered her sister. It was an amazing experience. In a way, a doctor was also born that day.”
Cheatwood shadowed Kallenberger several times during high school, college and medical school. She did a couple rotations with him again during her residency training. Now, with her medical degree in hand, she is Kallenberger’s newest partner.
Cheatwood remembers the moment he made her the offer to come work with him. “I was speechless initially, again wondering if he was actually serious. And then I nodded my head yes. It was wildly similar to the reaction I had when he asked if I wanted to deliver my sister all those years ago.”
“I feel like I’ve been shadowing him for 22 years,” laughs Cheatwood. “He has afforded me a tremendous amount of encouragement and exposure. He is a phenomenal teacher and an exceptional physician. I hope to continue following in his footsteps.”
Kallenberger has no doubt that Cheatwood will tread her own path, and is beyond proud of the physician she has become. “It is somewhat surreal working with her but I have worked with her so many times over the years as a mentor or as faculty that it feels natural.”
“I don’t know that this is necessarily a passing of the torch,” continues Kallenberger. “But I do want to groom her to be able to take over my practice one day when I decide to retire. It is comforting to know that someone with her compassion and skill set will be available to take care of my patients in the same way that I have tried to do over the last 42 years.”
Kallenberger estimates that he has delivered more than 15,000 babies in his lifetime. While he says some of them have grown up to be doctors, he says Cheatwood is the first he’s ever had the privilege to call partner.
“The transition we’ve made from student/teacher to colleagues has been interesting and entertaining,” Cheatwood jokes. “A few days after I started here, he told me to call him David now. I still can’t do it without laughing a little bit. I’ve heard people talk about their “work wife” or “work husband.” We definitely have a “work father/daughter” relationship. I have so much respect for him. He’s been such an advocate for me as a new physician. Even though I’m working beside him now, I will always look up to him.”

New findings cast light on lymphatic system, key player in human health

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Oklahoma Medical Research Foundation scientist Satish Srinivasan, Ph.D.

Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
The lymphatic system is a network of vessels and lymph nodes that spans the entire body. It is critical for good health and for the body to function properly. Defects in lymphatic vessels cause lymphedema, a disease characterized by dramatic and painful swelling in the limbs that often leads to infections.
Lymphedema can result from congenital mutations, surgery, radiation treatment for cancer or infection, and there is currently no cure. In addition to lymphedema, defects in the lymphatic system have been linked to a wide range of health consequences: cancer, atherosclerosis, Alzheimer’s disease and obesity.
Sathish Srinivasan, Ph.D., and Boksik Cha, Ph.D., at OMRF previously discovered that a particular pathway—known as the Wnt signaling pathway—regulates the development of the human lymphatic vascular system. In new research, published in the journal Cell Reports, they’ve found “the nuts and bolts of this important pathway.”
“We have identified the signaling molecules that activate this pathway,” said Srinivasan. “We also have learned which cells produce the signaling molecules, how they are sensed by the cells and how they are used in lymphatic development.”
Srinivasan was recruited to OMRF from St. Jude’s Children’s Research Hospital in 2013. His lab at OMRF has already identified several target genes for lymphedema. Srinivasan said that, after further study, this new information could eventually help researchers develop better therapeutic options for lymphedema and associated disorders.
“This signaling pathway has proved difficult to study, because it is complex and so little is known about how it functions normally, let alone when it goes wrong,” said Srinivasan. “Wnt signaling is aggravated and increased in breast cancer and colon cancer, but it is deregulated in diseases like Alzheimer’s and lymphedema.”
Srinivasan said drug companies are interested in finding molecules that can be targeted, either to promote or inhibit Wnt signaling, depending on the disease. “Our goal is to find whether such drugs could be used to treat humans with lymphedema and see if their disease can be managed, made less severe or even cured,” he said.
Other OMRF researchers who contributed to this research were Xin Geng, Ph.D., Riaj Mahamud, Lijuan Chen and Lorin Olson, Ph.D.

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