Dear Savvy Senior, Can you provide some tips on how to choose a good estate sale company who can sell all the leftover items in my mother’s house?  Inquiring Daughter

Dear Inquiring,
The estate sale business has become a huge industry over the past decade. There are roughly 22,000 estate sale companies that currently operate in the U.S., up nearly 60 percent from just 10 years ago. But not all estate sale companies are alike.
Unlike appraisal, auction and real estate companies, estate sale operators are largely unregulated, with no licensing or standard educational requirements. That leaves the door open for inexperienced, unethical or even illegal operators. Therefore, it’s up to you to decipher a good reputable company from a bad one. Here are some tips to help you choose.
Make a list: Start by asking friends, your real estate agent or attorney for recommendations. You can also search online. Websites like EstateSales.net and EstateSales.org let you find estate sale companies in your area.
Check their reviews: After you find a few companies, check them out on the Better Business Bureau (BBB.org), Angie’s List (AngiesList.com), Yelp (Yelp.com) and other online review sites to eliminate ones with legitimately negative reviews.
Call some companies: Once you identify some estate sale companies, select a few to interview over the phone. Ask them how long they’ve been in business and how many estate sales they conduct each month. Also find out about their staff, the services they provide, if they are insured and bonded and if they charge a flat fee or commission. The national average commission for an estate sale is around 35 percent, but commissions vary by city and region.
You may also want to ask them about visiting their next sale to get a better feel for how they operate. And be sure to get a list of references of their past clients and call them.
Schedule appointments: Set up two or three face-to-face interviews with the companies you felt provided you with satisfactory answers during the phone interviews.
During their visit, show the estate liquidator through the property. Point out any items that will not be included in the sale, and if you have any items where price is a concern, discuss it with them at that time. Many estate companies will give you a quote, after a quick walk through the home.
You also need to ask about their pricing (how do they research prices and is every item priced), how they track what items sell for, what credit cards do they accept, and how and where will they promote and market your sale. EstateSales.net is a leading site used to advertise sales, so check advertising approaches there.
Additionally, ask how many days will it take them to set up for the sale, how long will the sale last, and will they take care of getting any necessary permits to have the sale.
You also need to find out how and when you will be paid, and what types of services they provide when the sale is over. Will they clean up the house and dispose of the unsold items, and is there’s an extra charge for that? Also, make sure you get a copy of their contract and review it carefully before you sign it.
For more information on choosing an estate sale company, see National Estate Sales Association online guide at NESA-USA.com, and click on “Consumer Education” then on “Find the Right Company.

Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of “The Savvy Senior” book.

story and photo by Bobby Anderson, Staff Writer

A cough. A sniffle.
You feel something coming on. But what next?
You can call your doctor and hopefully get an appointment sometime in the next couple weeks.
Or you can get in your car and head to the local urgent care clinic and wait with 20 or 30 others doing the same thing.
What if there was a better way?
That’s what Dr. Mark Prather thought in 2013 when he came up with a unique service model that would eventually become DispatchHealth.
“Really anything you can think of you would get in your car and go to urgent care for but more,” Dispatch Community Engagement Manager Tiffany Traxler said, explaining the service that has recently expanded into the metro.
DispatchHealth is bringing back the house call with a modern technology twist. DispatchHealth gives patients ways to access convenient, high-quality acute care in the comfort of their home at the time of need.
DispatchHealth is redefining the healthcare landscape as an extension of a patient’s healthcare team and offering solutions for simple to complex medical problems all from the comfort of your home.
The concept dates back to 2013 when Prather was running the emergency department in Denver for Centura Health.
“They asked Dr. Prather if he could come up with a system that could be delivered safely in the home for patients who go to the emergency room with urgent needs but not emergent,” Traxler explained. “He knew the need and he knew how to make things mobile.”
“He started going out on calls.”
Working with the ambulance service through the 911 system, Prather helped more than 400 patients in 18 months in the comfort of their own homes.
The total cost savings to the health system was more than $1 million.
But saving patients the time, expense and hassle of an ER visit was priceless.
The model has spread like wildfire to Colorado Springs, Richmond, Phoenix, Las Vegas, Houston, Oklahoma City, Tacoma, Dallas and Springfield.
Blue Cross and Blue Shield – one of Oklahoma’s largest insurers – quickly saw the value.
“Blue Cross and Blue Shield saw what we were doing and the impact we were making,” Traxler said. “For the 65-and-under patient if you have Blue Cross and Blue Shield it’s an urgent care co-pay. For 65 and up all Medicare, Medicaid and Medicare Advantage plans … we bill as an urgent care.”
For some that can mean an urgent care visit in their home for less than $50.
Services include testing such as: blood tests on-site, strep test, flu swab, urinalysis, urine cultures, stool culture, test for blood in stool, pregnancy test, lactate, 12-lead EKG, PT/INR, rapid infectious disease testing and more.
Dispatch also provides medications such as: anti-inflammatories, IV antibiotics, IV fluids, prednisone, lasix, antiemetics, flu medications, laxatives, stool softeners, heartburn prevention, glucose gel, anesthetics, migraine cocktail, antihistamines and more.
IVs can be placed and fluids begun all in your home.
Breathing treatments can also be administered.
AVOID THE BUG
Last year’s influenza outbreak was one of the worst in nearly a decade and the severity of the outbreak was extreme. In fact, The Center for Disease Control and Prevention (CDC) recorded over 20,000 positive flu tests per week at the height of the outbreak.
While most seek treatment at an emergency room (ER) or urgent care clinic, when leaving one’s home the virus can be immediately exposed to others and cause further spread of the flu. Also, ERs and clinics can easily become overwhelmed with a high number of sick patients during flu season, leading to overcrowding, lengthy wait times and even physician burnout.
Adults can infect others one day before their flu symptoms even develop and can pass on the virus up to a full week after becoming sick.
“Flu comes on very, very quickly. If it’s 2 p.m. and you realize you don’t feel well you’re not going to get into your (doctor’s office),” DispatchHealth Market Director Amy Evans said. “With flu if you can get those anti-virals within that first day or two it cuts down on the length of flu.”
“When you’re talking about the elderly population and people with compromised immune systems that 12 hours means something.” To request on-demand urgent care brought to you call 405-213-0190

by Bobby Anderson, Staff Writer

A sociologist, a psychologist and a benedictine nun walk into a room.
Sounds like the beginnings of a good joke.
But for John Karlin, PhD, those are just a few of the cast of characters that helped create his new book: Fear, Religion, Politics: Well I’ll Be Darn!
Karlin spent the last year of his life writing this book that takes a look at the intertwining of three things deeply personal to Americans.
“It was incredible in the sense that how much insight humans have but not realize it,” Karlin said. “In researching this I kept seeing these little lights in other people’s works.”
Karlin was aided by Dr. Melvyn Preisz, Rhonda Bell, Judy Martin, Marsha McMillin, Gerry Lantagne and others in developing his second book. Each brought their own unique talents.
Preisz is a local clinical psychologist who befriended Karlin years ago.
“I agree with Dr. Karlin’s timely and insightful assessments of this unprecedented crisis,” Preisz said. “From my own psychological viewpoint, these enemies of our individual freedoms collude to divide and conquer the good within us, and to continue to attack our personal conscience from a buffet of lies.”
Karlin stresses he has no political motives with this book.
His wish for what readers walk away with is simple.
“Simply an understanding of those undercurrents, a complete, full, intense understanding of … what’s actually happening underneath the surface,” Karlin said. “I just expose those undercurrents, that was my whole concern. I write from a sociological perspective.”
“I’m not the only one who has picked up on this. What I found is pieces of those themes in many, many other works.”
Karlin cites some 120 references in his work, that he says was a labor love performed with dear friends.
“Our intent was to give seniors out there a message that you can do stuff like this. You’re never too old,” the 72-year-old Karlin said. ”Don’t just sit, you’re capable of doing stuff.”
More than 20 years of Karlin’s life have been spent in teaching, largely at Northwestern Oklahoma State in Alva, Oklahoma City University and Phillips University.
While teaching sociology and criminal justice at OCU, Karlin begin his friendship with Preisz.
Preisz introduced him to Lantagne, who introduced Martin, a former Benedictine nun and things began falling into place.
“It was just friends introducing friends,” Karlin said. “It was basically happenstance then realized ‘Gosh, look at all this talent.”
The motives were simple.
“I just didn’t like the way things were going in this country especially politically and socially in terms of the turmoil and discontent,” Karlin said. “I thought there had to be something underneath that. As a sociologist you always know that what’s on the surface isn’t always the whole story.”
“Sometimes in our culture there are some very deep undercurrents that help explain.”
Karlin recalled attending Louisiana State University for his doctorate. A conversation with an old fisherman came to mind.
The fisherman pointed to the Mississippi River and told Karlin to watch it closely.
“It’s just real slow, old man river kind of thing but underneath that is just incredible turmoil,” Karlin said. “The Mississippi in spots is almost a mile deep and a lot of people don’t realize that because the undercurrent is cutting it.”
“There are literally complete trees down there. That’s the way culture and society can be.”
That got Karlin thinking about what’s underneath today’s politics and headlines.
“What’s under that is not good,” he said.
Karlin’s book flows through three sequences with the first being our innate fear of death and how we view our own mortality.
“And how that came to actually produce the phenomena we call religion in society,” Karlin said. “Any religion, it doesn’t matter what it is, came from the fear of death because religion was a way to escape that tension and fear.”
The second sequence evaluated Christianity and the life of Jesus Christ.
“I looked at what (Jesus Christ) was actually trying to accomplish in his own time and he was trying to accomplish something,” Karlin said. “You’ll find that as somewhat of a shocker.”
The third sequence takes things into the political realm.
“That’s where the dream goes awry because a big chunk of our Christian community want to blend religion and politics to the point where they are no longer distinguishable and that’s not good,” Karlin said.
“That’s what has created most of the problems you see in society today. Basically, it’s the drive towards theocracy.”
Karlin’s book is now available on Amazon. He will do a benefit book signing for the Peace House at the Peace Festival at the Civic Center Music Hall November 10 from 10 a.m. to 4 p.m.
The Peace House will get $5 for every book sold.

INTEGRIS assumed operations of Deaconess Hospital and its affiliated family care clinics at midnight, Oct. 1.
Rex Van Meter is the newly named president of INTEGRIS Deaconess, as it is now called. The hospital is considered a campus under the INTEGRIS Baptist Medical Center umbrella.
Van Meter has been a part of executive leadership at INTEGRIS since 2001. He joined as vice president of finance at INTEGRIS Blackwell Hospital and was promoted to president there four years later. In 2012, he was named president of INTEGRIS Canadian Valley Hospital, and has led that facility to successive year-over-year record performances. Van Meter earned a bachelor of accounting from Northwestern Oklahoma State University and a master of health care administration from Trinity University.

by Bobby Anderson, Staff Writer

This fall has been pretty sweet for Belinda Winslow and husband Mike.
In September, she received the blessed news that her 27-year-old daughter was finally cancer free.
October saw her Watermelon Pie creation clean up in the awards category at the Oklahoma State Fair. The pie, an old recipe from her childhood, earned the FAIRest of Them All award as the best overall food creation. The fruity, creamy treat also was named the top overall sweet offering at the fair, dubbed Sweetest of the Sweet.
“We’ve had a good year this year,” Belinda Winslow smiled.
Going up against eclectic creations like deep fried coffee, Frosted Flakes chicken on a stick and Kit-Kat fries, Winslow’s watermelon pie blew away judges at the Great TASTE of a Fair competition which immediately precedes the September fair.
The event, staged to whet appetites and drum up publicity for the fair, was Winslow’s coming out party for her mobile food truck business.
Based out of Moore, the Winslows opened their trailer for business in March 2015 after scores of friends and family kept insisting they bring the watermelon pie to every gathering.
Winslow said some of those invites may have just been for the pie, but it was clear she had something on her hands that people really liked.
“It was a recipe my mom came across and she just loved it and we started making it,” Winslow said. “It just stuck.”
So did the idea of opening her own business. Her and her husband, who runs a full-time paint contracting business, began drawing up a business plan months earlier.
Cost projections outpaced savings for opening a traditional brick-and-mortar business.
“The food truck was the first thing we could think of,” Winslow admitted.
A business on four wheels came with its drawbacks.
Running a business in a trailer meant more prep work. Winslow typically makes her runs to Sam’s Club, Wal-Mart and the Chef Store the Tuesday before an event. Six to seven hours the following day are spent doing prep work, including cutting up some 20 to 25 watermelons by hand.
“It’s hard work, very hard work,” Winslow said of the business. “It’s not something you could just do on a part-time basis. It’s a full-time job.”
“You’ve got to pack it up, move it and have it ready on time.”
The concept also came with advantages.
Being on wheels means that Cutie Pies can be at almost any venue in the state with enough advance notice.
This month the trailer will pull up to Norman and the University of Oklahoma Day of the Dead Celebration. The following day Cutie Pies will be at Integris Baptist with 100 pies for a private event hosted by the radiology department.
Twelves days later you can find watermelon pie at the Luther Pecan Festival.
Outside of the State Fair, Winslow said one of the company’s best events is always the The Old Chicken Farm Vintage Barn Sale in Jones.
It’s a good thing Cutie Pies gets around because it will take you awhile to work through the menu. Watermelon pie may be the star but there’s a talented ensemble cast of banana cream cheesecake, root beer float pie, cherry limeade pie and cotton candy pie.
If sweet isn’t your thing they have savory covered, too, with Winslow’s chicken and corn frito pie.
The twist on the original frito pie includes santa fe chicken layered on Fritos doused in queso cheddar cheese mixed with feta, cilantro and a special chili lime mayo.
Wash it all down with a variety of lemonades – including watermelon, of course.
“This our first year to actually make money,” Winslow said.
And that’s despite a trying year.
Winslow’s daughter battled stage IV ovarian cancer before doctors announced she was cancer-free three days after her last surgery.
Through it all, Winslow has been her daughter’s caregiver, keeping her out of the truck for most events. That’s meant Mike pulling double duty.
“He’s been our savior. He’s saved both of our businesses,” Winslow said of her partner of 20 years.
But it all paid off this fall.
“It was kind of Heaven-sent because (my daughter) finished chemo and we had the fair,” Winslow said. “Right after the fair she had her surgery.”
“But she was still out there.”
All three of Winslow’s kids help in the business including a 21-year-old daughter and a 38-year-old son.
Her two granddaughters pitch in, too.
“They come stay with us every other weekend,” Winslow said. “They love to work on the truck and they hope we have leftovers, which doesn’t happen very often.”
So what’s next? Can she top Watermelon pie?
“I have somethings in the works for next year but I can’t tell you,” Winslow laughed.
You can find out where Cutie Pies Concessions will be next through their Facebook page.

Cutting-edge, non-surgical treatment at OU Medicine targets chronic stuffy nose
An Oklahoma woman is one of the first patients outside of a clinical trial to experience the benefits of a new, non-surgical treatment for her chronic stuffy nose.
Most of us have experienced a head cold so bad that it leaves you so stuffed up you can no longer breathe through your nose. For Denise Crozier, 56, it wasn’t a cold causing her chronic stuffed up nose or the pain and pressure that accompanied it. The Oklahoma City woman suffered from nasal polyps, soft, non-cancerous growths on the lining of the nose or sinuses.
“When you get a lot of inflammation, the lining of the nose becomes very swollen and redundant, and it forms a round structure that basically fills the nasal cavity,” explained Dr. Kibwei McKinney, an ear, nose and throat specialist with OU Medicine.
Surgery had been the first line of defense for patients like Crozier for whom treatment with oral steroids has failed.
“I had four surgeries in Seattle before moving to Oklahoma, and then since I have been here, I’ve had three,” Crozier said.
Each time, the surgery would initially bring relief, but before she knew it, the polyps would be back.
“Each time, she got some temporary relief, but almost like clockwork, it would come back and she would have a return of her symptoms,” McKinney said.
This time, though, McKinney returned from a recent conference with a new treatment option for Crozier a newly-approved, non-surgical treatment. It utilizes a tiny sinus implant. He explained to her that it could be placed without pain during a visit to his office at OU Medicine.
The implant is a small teardrop-shaped device that when deployed appears a bit like a badminton birdie. It’s placed under the guidance of an endoscope.
“I actually have a camera and scope that I look through to see the anatomical structures and then I place the splint with minimal discomfort,” McKinney said. “It basically stints open the cavity and then over time it treats the surrounding tissue with steroids, which are very effective at controlling polyp growth. As the steroid is leached out, the polyps occupying the space begin to melt away and the pressure associated with them also goes away.”
As a nurse, Crozier did her homework and quickly realized that this treatment could offer relief and save her from another trip to the operating room.
“Anything to keep me out of the OR is fantastic,” she remarked.
The device was placed quickly and without pain during an office visit with McKinney.
“They numbed me up, so I really didn’t feel a thing,” Crozier said.
After several months, she returned to McKinney’s office to have the device removed; and just as it had gone into place under endoscopic guidance, it also was removed that way in just a matter of seconds.
Crozier’s eyes watered just a bit, but she said there was no pain and the relief she has experienced has been incredible.
“It’s wide open in there. There are no polyps or anything. It works. It’s great,” she exclaimed, adding that she would easily recommend the procedure to anyone else facing the same battle she has faced with nasal polyps.
Specialists at OU Medicine say the new treatment provides a valuable option for patients unable to take oral steroids, as well as for those who are not good candidates for surgery or for whom repeated surgeries have failed to bring relief.

The holiday season is approaching, and the Oklahoma City Fire Department has a few safety tips for your family and friends. A small fire can double in size every 30-60 seconds. Following these safety messages will provide a safer winter and holiday season. The holiday season is approaching, and the Oklahoma City Fire Department has a few safety tips for your family and friends. A small fire can double in size every 30-60 seconds. Following these safety messages will provide a safer winter and holiday season. Smoke Alarms· Working smoke alarms should be placed inside and outside each bedroom and sleeping area. Install smoke alarms on every level of the home including basements. The Oklahoma City Fire Department has a “Project Life” smoke alarm program. Firefighters will install smoke alarms at no charge for qualifying residents of Oklahoma City. Contact information 405-316-2337, www.smokealarmsokc.com or www.Gratisalarmasokc.com.  Residents outside of Oklahoma City can contact your local fire department or Red Cross. · Test smoke alarms once a month while practicing your escape plan. Practice your escape plan based on your mobility and always have a meeting place outside the home. · Replace batteries once a year. When replacing the 9-volt battery consider upgrading to a 10-year lithium battery smoke alarm.· Replace all smoke alarms after 10 years or before expiration date located on the backside. · People with hearing impairment can contact the Oklahoma Assistive Technology Foundation (OkAT), 888-885-5588 or email abletech@okstate.edu.     OkAT will install smoke alarms with strobe lights and bed shaker for qualifying Oklahoma residents. Apply at www.okabletech.okstate.edu. * According to the National Fire Protection Association (NFPA), “3 out of 5 fire deaths happen in homes with no smoke alarms or the alarms are not working.”Heating Safety·Keep space heaters a minimum of 3-feet away from anything that can burn. The 3-foot clearance must include people and pets. Never use extension cords with space heaters. Plug them directly into the outlet and ensure the space heater is the only item plugged into the outlet. Turn off and unplug when not in use or going to bed. ·Heating systems and chimneys should be inspected and cleaned every year by a qualified professional. Schedule your inspection and cleaning before use.  ·Keep metal fireplace screens or heat-tempered glass secured and in the correct position when in use. Discard cool ashes from the fireplace into a metal container. Keep the metal container at least 10-feet from your home.  ·Never use ovens, stove top, or open burning to heat your home. Open flame heat sources should have a venting system. The use of alternative heating sources inside your home could have deadly consequences caused by carbon monoxide poisoning or fire. ·Always follow the manufacturer’s instruction. ·Install Carbon Monoxide (CO) alarms outside each sleeping area and on every level of the home.      *According to NFPA, “Half of home heating fires are reported during the months of December, January, and February.”Holiday Safety·Don’t block exits with decorations. ·Follow manufacturer’s instruction and do not overload extension cords. ·Keep candles away from children and pets. ·Ask smokers to smoke outside. Wet all cigarette butts before discarding. ·Never leave food cooking on the stovetop unattended. Make sure you are alert when cooking. ·Cut 2 inches off the base of a live Christmas tree before placing in the stand. Add water to your tree stand daily. Don’t put heating sources or candles near the Christmas tree. Always turn off Christmas tree lights before leaving home or going to bed. ·Immediately remove the Christmas tree from inside your home after the holidays or when it is dry.  *According to NFPA, “Two of every five home decoration fires are started by candles.”Additional fire safety information is available at www.nfpa.org/Public-Education.
This is the first of a series of safetey articles provided by  Oklahoma City Fire Department, Oklahoma County Sheriff Department and the Oklahoma City Police Department.

Expanding and strengthening their team and service

SYNERGY HomeCare proudly opened their doors over 5 years ago in Edmond, Oklahoma. Weama Kassem, CEO and President of SYNERGY HomeCare, has always dreamt of having a business that centered around caring for others; specifically, our aging community. Weama has been fortunate enough to attract a team of professionals with the same heartfelt drive and talent. The people Weama has assembled have accomplished some incredible things by always putting their clients’ needs and happiness first. The SYNERGY HomeCare team always refers to each other as “SYNERGY Family” and they work together to create an atmosphere of care and respect for each other and for their clients and families.
Weama opened her second office in December 2016 in Norman, Oklahoma. This enabled the company to reach and connect a larger clientele and reaching beyond Edmond and Oklahoma City. One of the most essential guidelines in opening the new location has been to duplicate their high standard of care. SYNERGY HomeCare does not use contracted caregivers, all are employees who must completed in-house training, along with continued monthly and quarterly training programs. This ensures the caregivers are not only qualified, but it strengthens the support and bonds within the company itself. Each caregiver is a Certified Nursing Assistant and/or a Certified Home Health Aide. They are each insured and bonded by SYNERGY HomeCare and strive to provide excellent care and support to both clients and their families.
SYNERGY HomeCare is very pleased to announce that Jeff Aynes has joined the SYNERGY Home Care Team as our Director of Sales and Marketing. Jeff has been a strong advocate for health care in Oklahoma for many years and will make a great leader on our team. Jeff is a father of two beautiful ladies and grandfather of two beautiful girls. He went to the University of Central Oklahoma and Oklahoma State University where he studied Marketing, Public Relations, and Broadcasting. Jeff is a Past President of Marketing Plus for Healthcare and currently serves as Secretary. He is currently serving as President of the Northside Marketing Alliance, as well as, Secretary. He has served in the community for many years as a member of the Shriner’s, Scottish Rite, Eastern Star, Amaranth, and Masons where he is a Past Master. He has been volunteering with Muscular Dystrophy, Cerebral Palsy Association, and Make Promises Happen Camp for over 25 years. His passion outside of Sales and Marketing is music. He has owned Jammin’ Jeff Entertainment for over 25 years and has performed over 1,800 events. Jeff joins the SYNERGY staff from AllianceHealth Midwest where he served as Director of Marketing for the Behavioral Health Program. Prior to going to AHM, Jeff served for over 5 years at Absolute Senior Care of Oklahoma City and A Premier Senior Home Care of Tulsa as their Director. We are beyond thrilled and honored that Jeff has chosen to join our team and know he is truly a valuable asset that will provide wonderful support to our growing company.
Together, Weama and Jeff, will be able to provide assistance to our aging community, education to our referral partners, knowledge to our team of growing caregivers, and a bright and smiling face to see each time you encounter them. Serving people is what SYNERGY HomeCare does every day and it is truly the drive and passion of both Weama and Jeff. With over 100 caregivers and five years in business, the SYNERGY HomeCare team stands ready to answer specific questions about care.
Whether you are a senior living on your own, with an aging spouse, or you have an aging parent – there are some key things to keep in mind when selecting a home care company. First, is the home care company licensed in the state? Companies are reviewed annually to determine their eligibility, and this is a perfectly normal question to ask a potential company. Ask to see a copy of their business license. Second, ask if the caregivers are employed by the company instead of being contract labor employees. It may seem beneficial to contract our work, but actually you can face many liability and scheduling issues down the road. Ask the provider to include client AND their family members in developing the plan of care. SYNERGY HomeCare has full-time RNS on staff to specifically build a plan of care for each new client and they spend the time you need to sort out every little detail. Lastly, ask for a list of references so you can check in on who you are considering to employ! We are all use to providing references when applying for a job. SYNERGY HomeCare is happy to answer questions like these anytime.
SYNERGY HomeCare is a group of Oklahomans that you can trust. Weama, Jeff, and the whole team are honored to provide care to this amazing community and welcome your call anytime, day or night!

SYNERGY HomeCare is located at 13720 N Bryant Ave. Edmond, OK 73013 405-254-3046
www.synergyhomecareedmond.com

Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
The lymphatic system is a network of vessels and lymph nodes that spans the entire body. It is critical for good health and for the body to function properly. Defects in lymphatic vessels cause lymphedema, a disease characterized by dramatic and painful swelling in the limbs that often leads to infections.
Lymphedema can result from congenital mutations, surgery, radiation treatment for cancer or infection, and there is currently no cure. In addition to lymphedema, defects in the lymphatic system have been linked to a wide range of health consequences: cancer, atherosclerosis, Alzheimer’s disease and obesity.
Sathish Srinivasan, Ph.D., and Boksik Cha, Ph.D., at OMRF previously discovered that a particular pathway—known as the Wnt signaling pathway—regulates the development of the human lymphatic vascular system. In new research, published in the journal Cell Reports, they’ve found “the nuts and bolts of this important pathway.”
“We have identified the signaling molecules that activate this pathway,” said Srinivasan. “We also have learned which cells produce the signaling molecules, how they are sensed by the cells and how they are used in lymphatic development.”
Srinivasan was recruited to OMRF from St. Jude’s Children’s Research Hospital in 2013. His lab at OMRF has already identified several target genes for lymphedema. Srinivasan said that, after further study, this new information could eventually help researchers develop better therapeutic options for lymphedema and associated disorders.
“This signaling pathway has proved difficult to study, because it is complex and so little is known about how it functions normally, let alone when it goes wrong,” said Srinivasan. “Wnt signaling is aggravated and increased in breast cancer and colon cancer, but it is deregulated in diseases like Alzheimer’s and lymphedema.”
Srinivasan said drug companies are interested in finding molecules that can be targeted, either to promote or inhibit Wnt signaling, depending on the disease. “Our goal is to find whether such drugs could be used to treat humans with lymphedema and see if their disease can be managed, made less severe or even cured,” he said.
Other OMRF researchers who contributed to this research were Xin Geng, Ph.D., Riaj Mahamud, Lijuan Chen and Lorin Olson, Ph.D.