Wednesday, February 11, 2026

TRAVEL / ENTERTAINMENT: Entertainment: In the Presence of Greatness – Part Three

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Marilyn Maye in Concert performed most recently at the OKC boat house last year.
Tommy Tune performed a one man show at Lyric’s Plaza Theater.

Photography and Text by Terry “Travels with Terry” Zinn t4z@aol.com

The trip down memory lane continues for the live experiences and recognition of outstanding performers and venues. By recalling our good times and interactions, if only as an audience member, it gives us comfort and enjoyment remembering our past efforts, and gives us hope for more live entertainment experiences in the near future.
If you are a loyal long time reader here, there is no surprise that I am an admirer of the 92 year old, iconic cabaret singer, Marilyn Maye, who performed most recently at the OKC boat house last year, courtesy of Central State University. I have seen her a couple of times in Dallas and other venues. She holds a record number of appearances on the Tonight Show, starring Johnny Carson. Her enthusiasm for life and humorous attitude is only surpassed by her smooth, easy and warm voice. She is a testament and a life affirmation for all seniors.
Another theater veteran, for ever young yet a senior, Tommy Tune (currently 81), who performed a one man show at Lyric’s Plaza Theater. He of course was in the original Broadway cast of “Hello Dolly” and has performed and directed many Broadway shows, including “My One and Only” with Twiggy. His Tony and other theater awards are numerous . This tall Texan’s humor is infectious. His back stage stories are enlightening. His most touching story was how he lost decades of theater memorabilia and souvenirs when hurricane Sandy flooded parts of Manhattan and his storage unit. Fun to see him tap dance in red boots. He presented two nights, I saw both, and noticed each show was a bit different, as he went with spontaneous changes. After the performance he invited fans to accompany him on stage – where he let us be close and personal with photographs and to be in his presence. His optimism, generosity and theater history certainly makes him a person of greatness.
This reminds me of another offering by Lyric Theater of Oklahoma when they featured Chita Rivera. Senior Rivera was awarded the 2018 Tony for Lifetime achievement and was a Kennedy Center Honoree. Always enchanted by her dancing and mischievous personality, it was a pleasure to meet and greet her at an after party. She was gracious, but her handler (her assistant) was less so, bordering on rude. Odd how some personalities don’t recognizance that their assistants can mar the public’s perception and experience. I could list other occasions which were tarnished by their neglect to properly instruct them to be considerate to the fans, to which they owe part of their success.
You never know what’s going to blossom when going to a live theater event. Such was the case many years ago when the Oklahoma BLAC organisation brought in the three woman musical play called, “Blues In The Night.” It was performed as a benefit on the thrust stage of the Stage Center/Oklahoma Theater Center/aka the Mummers Theater. Sadly is was not well attended , and sadly the theater building is now a parking lot. Its headliner was the provocative Chanteuse Eartha Kitt. Best known for her “Santa Baby” recording but in this Oklahoma visit she performed and gave an extensive seminar on her life and even touching on her political activism, during the President Lyndon Johnson era. Even more astonishing was her willingness to pose for me and my camera. I treasure those times and images of the late Eartha Kitt. To her credit I sent her a couple hard copy black and white prints to her NYC address for her signature and she did such and returned to me. The Presence of Greatness.
Another photo opportunity was with Ballet Oklahoma’s performance and celebration of “Rodeo,” and the Ballet from “Oklahoma,” originally choreographed by Agnes de Mille. I was so pleased when I sent de Mille her copies of my photography of a dress rehearsal where she autographed my hard copy black and white photography. Agnes de Mille; truly greatness of the Ballet world.
While its fun to recall meetings with well known celebrities, let’s not forget our relatives and friends which also might fall into the category of greatness for their humanity and friendship.

Mr. Terry Zinn – Travel Editor
Past President: International Food Wine and Travel Writers Association
3110 N.W. 15 Street – Oklahoma City, OK 73107
https://realtraveladventures.com/?s=terry+zinn
https://realtraveladventures.com/?s=zinn
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www.martinitravels.com

Shawnee Nurse receives Daisy Award

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Tress Hindman, RN, was the recipient of The DAISY Award for her compassionate patient care, but also for her kindness and support of the staff.

SSM Health St. Anthony Hospital – Shawnee recently recognized one of its nurses with The DAISY Award for Extraordinary Nurses. The award is part of the DAISY Foundation’s program to recognize nurses that go the extra mile for their patients, family and team members.
Tress Hindman, RN, was the recipient of The DAISY Award for her compassionate patient care, but also for her kindness and support of the staff.
In Hindman’s nomination, the staff stated, “Tress as ‘an angel with hidden wings.’” We are thankful for Tress selflessly taking time out of her busy schedule to be of service to her colleagues in their time of need. She is truly an angel indeed!”
The not-for-profit DAISY Foundation is based in Glen Ellen, CA, and was established by family members in memory of J. Patrick Barnes. Patrick died at the age of 33 in late 1999 from complications of Idiopathic Thrombocytopenic Purpura (ITP), a little known but not uncommon auto-immune disease. The care Patrick and his family received from nurses while he was ill inspired this unique means of thanking nurses for making a profound difference in the lives of their patients and patient families.
Nurses may be nominated by patients, families, and colleagues, and they are chosen by a committee of nurses at St. Anthony Hospital to receive The DAISY Award. Awards are given throughout the year at presentations given in front of the nurse’s colleagues, physicians, patients, and visitors. Each honoree receives a certificate commending her or him for being an “Extraordinary Nurse.” The certificate reads: “In deep appreciation of all you do, who you are, and the incredibly meaningful difference you make in the lives of so many people.” The honoree is also given a beautiful and meaningful sculpture called A Healer’s Touch, hand-carved by artists of the Shona Tribe in Africa.

November election holds major ramifications

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Sen. Clark Jolley is one of the supporters behind State Question 792 which would allow wine to be sold in Oklahoma’s grocery stores.

by Bobby Anderson, Staff Writer

The presidential election isn’t the only thing voters in Oklahoma will have a chance to decide this November.
A penny sales tax for education, the right to farm and selling wine in grocery stores are just a few of the issues that will also be decided when voters go to the polls on November 8.
Seven state questions have made their way to the ballot and several are being hotly contested by the different sides.
Here’s a quick look at both sides of each issue.
State Question 776
This state question involves Oklahoma’s right to exercise the death penalty.
The language allows the Oklahoma Legislature to be expressly empowered to designate any method of execution not prohibited by the United States Constitution.
Opponents argue a state question to amend the constitution is unneeded.
State Question 777
One of the more hotly contested items on the ballot, SQ 777 has been touted as the right to farm bill. Opponents call it the right to harm bill.
Oklahoma Farm Bureau, the Oklahoma Cattleman’s Association and the Oklahoma Pork Council are three of the largest supporters of the question.
“SQ 777 will protect our ability to use science based production methods to humanely produce food and fiber,” said Terry Detrick, president of the American Farmers & Ranchers/Oklahoma Farmers Union. “We are in a daily struggle with adverse weather conditions, burdensome regulations and contrary markets. SQ 777 will lend stability to our industry by encouraging younger generations to be involved in agriculture without worrying about outside influences with an anti-agriculture agenda.”
Opponents of 777 call it a “wolf in sheep’s clothing” and are backed by the Sierra Club and the Humane Society of the United States.
The Edmond City Council formally passed a resolution opposing State Question 777 earlier this year and former University of Oklahoma Coach Barry Switzer has also announced he is in opposition.
State Question 779
Oklahoma has one of the worst-funded education systems in the nation. State Question 779 looks to help remedy this by creating a limited purpose fund to increase funding for public education through a penny sales tax.
The revenue to be used for public education shall be allocated: 69.50% for common school districts, 19.25% for the institutions under the authority of the Oklahoma State Regents for Higher Education, 3.25% for the Oklahoma Department of Career and Technology Education, and 8% for the State Department of Education.
It also requires teacher salary increases funded by this measure raise teacher salaries by at least $5,000 over the salaries paid in the year prior to adoption of this measure.
Opponents don’t like the idea of taxing Oklahomans further under any circumstances
State Question 780
This measure amends existing Oklahoma laws and would change the classification of certain drug possession and property crimes from felony to misdemeanor. It would make possession of a limited quantity of drugs a misdemeanor.
Proponents say it will ease prison overcrowding. Opponents fear lower charges would be less of a deterrent.
State Question 781
This question piggybacks on the above question.
This measure creates the County Community Safety Investment Fund, only if voters approve State Question 780, the Oklahoma Smart Justice Reform Act. Any savings realized by the state would be distributed to counties for community rehab programs.
State Question 790
After the removal of a Ten Commandments statue from the Oklahoma Capitol grounds, this question arose.
If this measure repealing Article 2, Section 5 is passed, the government would still be required to comply with the Establishment Clause of the United States Constitution, which is a similar constitutional provision that prevents the government from endorsing a religion or becoming overly involved with religion.
Oklahoma’s constitution currently prohibits the government from using public money or property for the direct or indirect benefit of any religion or religious institution.
State Question 792
This question would allow the sale of wine in grocery stores and convenience stories while also allowing liquor stores to sell items other than alcoholic beverages in limited amounts.

Sen. Clark Jolley is a supporter for a number of reasons.
“It means tremendously increased convenience for (seniors),” Jolley said. “I think that’s something that will really appreciate and enjoy having.”
The issue is also one of modernization for Jolley, who terms Oklahoma liquor laws as oftentimes “fuddy duddy.”
“For Oklahoma to modernize our laws to really come into conformity with the rest of the country … will have a great impact on us having our young people want to be in Oklahoma,” Jolley said. “I think that’s a huge testament to why we should modernize our laws.”

A promise fulfilled

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Missy Beckett and Stacy Wingfield make a difference in the lives of families through Promise Care Hospice.

story and photo by Bobby Anderson, Staff Writer

Hand-written cards.
The joy of simply being present with loved ones and making their day a little brighter.
The pride that comes with honoring a loved one who gave their life in the service of country.
These simple things have always been foundational for Missy Beckett.
As a registered nurse, Beckett has cared for people from all walks of life, all the while knowing that memories they create will last a lifetime.
It’s this approach that Beckett promised to keep as the director for the aptly named Promise Care Hospice service.
Promise Care is locally and privately owned and Beckett has worked with the owner more than a decade now.
The focus has and always will be personal.
“I want to be small,” Beckett said. “As an RN and the director I want to know everyone. I want to know who my team is talking about. I want to know every single person’s name. I want to know their families. I don’t want ever to be too big to not know why I’m doing this.”
Promise Care is comprised of an expert teams of caregivers consisting of registered nurses, physicians, home healthcare aides, social workers, chaplains, bereavement counselors and trained volunteers.
The palliative care offered eases pain and discomfort for all who experience it.
Social and spiritual support for both patients and their loved ones is bedrock.
Volunteers are often the lifeblood of a quality hospice experience.
That’s where Stacy Wingfield comes in. Promise Care’s volunteer coordinator hand picks those individuals with both the heart and compassion for the role.
Wingfield knows no paycheck could ever be equal both the service volunteers provide and the what they receive in return.
“They’ve gotten a lot of strength,” Wingfield said of her volunteers. “We have training all along the way. You don’t have to have any medical background at all. It’s very interesting the different areas. You could be a florist and want to volunteer to put arrangements together.”
“You could be a masseuse and maybe come do hand massages or an art student who wants to make cards and do crafts. There are so many different avenues.”
One of Wingfields volunteers is an author who comes in after book tours and takes her book into a home and reads while in costume.
“The older you get the more life has thrown at you and the more you do understand where people are coming from,” Wingfield said.
Beckett knew of a woman through healthcare that transportation circumstances had left her homebound. She decided to present her the opportunity to volunteer.
“It has changed her entire outlook on everything to be able to get out and visit and help and spend time with people,” Beckett said. “It’s super important for the patient to have a neutral person to be able to tell their fears. They’re not going to tell their family. Sometime they’ll tell us as a nurse but to have someone who can go in and spend four or five hours at the bedside and just watch TV or read or have a conversation it’s so important.”
“And it’s important for the family to get out of the house and get a break and we really encourage that.”
From the outset, Beckett has brought her staff out into the community when they’re not in patients’ homes.
Once a month you’ll find the Promise Care team working at a homeless shelter serving others.
Every year you’ll find Beckett and staff handing out turkeys with a local law firm.
“Our group is really unique. We like to get out and go do things probably a lot of other businesses don’t do together,” Beckett said.
Remembering the holidays are always packed with events, Beckett was scolded by her staff this year when she suggested they take December off from the shelter serving line.
“They got mad at me,” Beckett laughed. “We like to give back. I think for most of the staff we all have to have a paycheck but I think we’d all do this for free.”
Honoring loved ones is what Promise Care is all about.
And Beckett admits she has a soft spot for veterans.
“I’m a Lawton girl so veterans are near and dear to my heart,” she said. “My dad is buried at the national cemetery. People on our team are veterans so we want to honor them, too.”
It’s those little things along the way that most don’t realize that are actually the big things in life.
And it’s those moments that Beckett promises to make count.

Medicare Fraud Prevention Week:

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Join the Oklahoma Insurance Department for the Summer Senior Fraud Live Events This Summer

In conjunction with the first national Medicare Fraud Prevention Week, the Oklahoma Insurance Department’s (OID) Medicare Assistance Program (MAP) is inviting Medicare beneficiaries to the Summer Senior Fraud Live Events on June 23 and July 14. OID has partnered with MAP, the Oklahoma Social Security Administration, the Oklahoma Department of Securities, the Oklahoma Attorney General’s Office, AARP Oklahoma and the National Insurance Crime Bureau to educate and empower Oklahomans in the fight against fraud targeting senior citizens.
“We’re excited to bring back these in-person events and continue to work with our partners to help Oklahomans protect themselves from fraud,” Director of the MAP division Ray Walker said. “Educational events like this will help individuals stay safe and protect the Medicare program for generations to come.”
The Summer Senior Fraud Live Events, funded in part by the SMP grant through the Administration for Community Living, will be held at the OID’s Oklahoma City office. These in-person events will consist of two one-day sessions led by speakers with diverse areas of expertise such as state agency directors, Medicare professionals and fraud prevention professionals. The topics include Medicare and healthcare fraud, contractor fraud, cyber scams, investment fraud and securities fraud. These events are free for senior adults and include breakfast. Registration is required because of limited capacity. To register, visit oid.ok.gov/summerseniorfraud/.
The Medicare Fraud Prevention Week, held June 5-11, kicks off on June 5, or “6-5,” because most people become eligible for Medicare when they turn 65 years old. Learn more about Medicare Fraud Prevention Week at www.smpresource.org
If you have questions about other insurance issues, please contact the Oklahoma Insurance Department at 1-800-522-0071 or visit our website at www.oid.ok.gov.

Oklahomans head for the hills…

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by Ron Hendricks

Oklahomans head for the hills, mountains actually, Salt Lake City for the annual Hearing Loss Association of America national convention. The HLAA convention is held every year in late June in various cities across the country. The Central Oklahoma Chapter (COCHLAA) sponsored the convention here in Oklahoma City in 2007, the One Hundredth birthday of Statehood. This year two members will receive national awards. Vernice Meade; Spirit of HLAA and Sharon Hendricks; Website. COCHLAA is a very active chapter and brings home national awards almost every year. The convention is an opportunity for members to meet and exchange ideas. There are speakers on all sorts of topics from the latest technical advances in hearing aid technology to well known motivational experts, and always, food and fun.
COCHLAA’s summer schedule is more relaxed. in early June we enjoyed a bingo and pizza night. July 21st we will hold a game night with sandwiches and August 5th is the annual Ice Cream Social where new chapter officers will be named and our two scholarship winners will be introduced. All meetings are held at the Lakeside United Methodist church, 2925 NW 66th St. The public is invited and there is no charge. September thru May meetings are a little more formal with a guest speaker and a business meeting. All are hearing friendly. For convenience sake, there are two group meetings monthly. Evening meetings are on the 2nd Monday at 6:30 PM and the day group meets on the 3rd Thursday at 1PM. For more information visit the website. WWW. OKCHearingLoss.org

OKC Hosts Free 2022 World Paddlesport Festival Festival

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Women compete in Stand Up Paddling World Cup Racing on the Oklahoma River last August.

Story by Darl DeVault, Contributing Editor

The men paddle in one of several preliminary heats in the Canoe Sprint Super Cup last August on the Oklahoma River.

World-class paddlers will compete August 26-28 at the 2022 World Paddlesport Festival at RIVERSPORT’s $100 million venue on the Oklahoma River for medals and prize money. The events are free for spectators and feature International Canoe Federation Canoe Sprint Super Cup and Stand Up Paddling World Cup Racing, along with first-in-America Red Bull Rapids- a wacky race in homemade boats down RIVERSPORT Rapids.
“We are so excited to welcome these athletes to Oklahoma City,” said Elizabeth Laurent, chief marketing officer for the organization. “Watching the Olympic and World Champion athletes on the water is an amazing experience – you really get that Olympic feeling when you see all of the country flags and watch the competition at this level. We hope everyone will come out and join us in welcoming these athletes to OKC.”
This marks the second straight August OKC will host prestigious ICF events after RIVERSPORT hosted the 2021 ICF Super Cup in its international television first night racing last year. Previously scheduled for Moscow, Russia, this year’s events were moved to OKC due to an International Olympic Committee directive after Russia invaded Ukraine.
The free three-day festival will also feature community dragon boat, kayak and SUP racing, plus full days of family fun and fireworks Saturday night.
Many competitors will be coming to compete in Oklahoma after competing in the world championships in their events August 3-7 in Halifax, Canada.
The international events play out before prime seating at the Boathouse District’s Finish Line Tower terrace as the centerpiece of the multi-day race event. The Sprint Cup racing runs August 26-27, and the Stand Up Paddling World Cup extends three days, August 26-28.
The Red Bull Rapids event Saturday, August 27, is all about fun, where the wildest whitewater race where showmanship and ingenuity take the top prize. This group challenge of 50 teams have made creative, wacky vessels to race down a 258-yard whitewater rapid course. The teams of 2-5 people 18 years and older are scored on the creativity of their vessel, along with how fast they descend and how far they stay afloat.
The top three placers earn exclusive Red Bull experiences. Judging is done by Red Bull athletes, coaches, and Oklahoma native Darci Lynne. Lynne is the season 12 winner of NBC’s “America’s Got Talent,” where she received the most votes for a final performance in the history of the show at age 12. Now 17, singer and ventriloquist Darci Lynne Farmer is touring America with show dates until November.
Oklahoma City’s Riversport is unique in offering all these events at one venue. It is the only city in the world to provide athletes with whitewater slalom, such as the Red Bull Rapids will use, and a venue for international-level flatwater sprinting. In its 16th year of making sports history, the venue is the only permanently lit flatwater course in the world. Completed in 2013, the permanent racecourse lighting along the river was integral to the MAPS 3 Oklahoma River improvements.
Canoe sprint takes place on a flatwater course, and races are contested by two types of boat, canoe (C) and kayak (K). In a canoe, the paddler competes in a striding position using a single-blade paddle, in contrast to the double-bladed paddle used in a sitting position in a kayak. International level, the discipline distances are from 200m to 5000m, individually and in teams of up to four. Each discipline is categorized by boat type, number of competitors per boat, gender, and race distance.
RIVERSPORT is known as an innovator in Olympic sports and outdoor recreation. The nonprofit RIVERSPORT Foundation has developed Oklahoma City’s Boathouse District. It has become one of the world’s premier urban outdoor adventure and water sports venues. It regularly hosts national and international races in both rowing and canoe/kayak. Located at America’s crossroads, the Boathouse District features iconic architecture, world-class adventure sports and recreation, and robust programming for all ages.
It is an official US Olympic and Paralympic Training Site and a model for other communities to embrace bold ideas and bolster outdoor culture.
The International Canoe Federation is the umbrella organization for all national canoe organizations worldwide. It is headquartered in Lausanne, Switzerland, and administers all aspects of canoe sport worldwide.
The full schedule for the weekend events is available online: 2022 ICF World Events (riversportokc.org)
Riversport is located at 800 RIVERSPORT Dr. Oklahoma City, OK 73129.

2022 World Paddlesport Festival – ICF World Events:

Saturday, August 27 • 10 a.m. to 10 p.m.

2022 ICF Canoe Sprint Super Cup Racing | Aug 26-27

2022 ICF Stand Up Paddling World Cup Racing | Aug 26-28

2022 Red Bull Rapids | Aug 27

Join RIVERSPORT for this incredible event featuring top paddlers from around the world competing in Super Cup and World Cup events, plus Red Bull Rapids – a wacky race in homemade boats down RIVERSPORT Rapids. We’ll also have community dragon boat, kayak and SUP racing plus a family fun and fireworks Saturday night. Plan to join us for a full day of fun, and read on to learn how Oklahoma City was invited to host the historic ICF Super Cup and World Cup events.

NRH building smoke – free families

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Nurse Manager Alyson Heeke, RN, Jerry Deming, TTS-CTS, and Director of Patient Care Services Susie Graves, RN have been instrumental in helping the health system create a Smoke-Free Families initiative.

by Bobby Anderson
Staff Writer

It’s the gamut of reactions that Jerry Deming, TTS-CTS, receives when she counsels patients in the Norman Regional Health System about their tobacco use.
In her tobacco cessation role she’s been screamed at. She’s been stared at, through and around.
She’s been shunned and she’s even been hugged.
But this year she’s been able to help Norman Regional’s nurses develop a new Smoke-Free Families campaign that is gaining traction.
Deming began working with the Women’s and Children’s unit after Norman Regional nurses and managers sought help.
“There was an understanding that there were a lot of women leaving the hospital to smoke,” Deming said. “This is a very common problem. I’m in contact with people worldwide and we all deal with this problem in our hospital and clinic settings.
“We all scratch our heads and think ‘what are we going to do to handle this.’ It’s a big problem. It comes up again and again.”
Staff understood that once a mother and her baby went home then it would be easier for the patient not only to smoke, but smoke around the child.
Deming brought forward the idea that it’s a population issue and not one of monitoring.
“We needed to drill down a little bit deeper and figure out how we can help these people get through a hospital visit staying away from tobacco use and even contemplating the idea of … even quitting to have a smoke-free family.”
When leaders got together to decide a plan of action they realized they were entering uncharted landscape. Nowhere could they find a comprehensive plan dealing with the in-hospital maternity population.
Hospital stays are often so short that no one had really figured a good way to approach the issue.
Planning meetings included physicians and nurses. A craving scale – much like a pain scale – was developed.
Nurse Manager Alyson Heeke, RN, saw an opportunity.
“Part of the reason we started this in the first place is we noticed there was an awful lot of times our babies were traveling back and forth to the nursery so their parents could go outside and smoke,” Heeke said. “That became a big concern for us just in the fact they were only with us 24 to 48 hours and a good portion of the time these folks who were really addicted the babies were in the nursery sometime 20 out of 24 hours.
“We couldn’t provide what we needed for our patients if they were always outside.”
Nursing became involved in the LEAN (Lean Education Academic Network) team project helping develop educational material including posters for the room and signage for outside.
“The nurses really did want it to be a successful process for the patient as much as possible and not to be the police officer,” Heeke said. “They wanted to help them understand this also impacts how well they bond with their baby, how they do with their breastfeeding issues and all those other things which are complicated by smoking.”
Director of Patient Care Services, Susie Graves, RN, said many women who are able to quit smoking for their pregnancy often will allow themselves to resume after they deliver.
“Part of what we wanted to do was help them through. Don’t have a start date. Let that continue,” Graves said. “They all know they shouldn’t smoke … but we’re just there not as judges but as support and giving them the resources they need.”
If the patient agrees, nurses are assessing each patient every shift regarding their tobacco usage and craving level.
“(Before) nurses felt pretty helpless,” Heeke said. “Their patients would come from a C-section and be begging for a wheelchair the second the baby was born to go outside and have a cigarette.
“At this stage, with all the things we’ve created it’s given our nurses an opportunity to have something to say to the patient beyond ‘don’t you think it would be a good idea to quit.’”
Deming travels through the halls of both Norman Regional hospital complexes visiting with patients who have indicated a history of tobacco use.
For nine years now she has worked with smokers. Some are just thinking about quitting. Others are desperately looking for a way out.
And some won’t even acknowledge she’s standing in front of them.
She terms her approach as “motivational interviewing.” She stresses to her patients that she’s not there to judge.
Nearly every person Deming visits understands that they need to quit tobacco. Many have tried multiple times on their own without success.
“When we look at this population it’s the most difficult population to approach,” Deming said. “Most people smoking during their pregnancy feel ashamed of it. They don’t like to talk about it. Of course, they are very addicted to tobacco at this point because they haven’t stopped smoking. Most people know there’s going to be a health issue related to that.”
And now Norman Regional nurses have even more to offer to help these patients quit.

A Yard Sale to benefit the Alzheimer’s Association

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Please bring any unwanted items to our office (between 8a-5p) and we will ensure to clean and price them accordingly! All items received will be sold in our Yard Sale on June 8th and June 9th between 8a-5p. ALL PROCEEDS GO TO BENEFIT THE ALZHEIMER”S ASSOCIATION! Please feel free to donate items AND attend the yard sale! We look forward to raising awareness with you!

OMRF Study Ties Autoimmune Disease to Aging

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Oklahoma Medical Research Foundation scientists Harini Bagavant, Ph.D. (Left), and Umesh Deshmukh, Ph.D. (Right)

Often the concept behind a scientific study is quite complex. But sometimes it’s simply a matter of proving an idea that seems like common sense.
And so it was for Oklahoma Medical Research Foundation scientists Harini Bagavant, Ph.D., and Umesh Deshmukh, Ph.D.
Their discovery partially answers a lingering mystery of Sjögren’s, an autoimmune disease that affects moisture-producing glands. The condition causes painful dry eyes and mouth and can result in irreversible tissue damage, neurological problems, lung disease and cancer. Up to 4 million Americans live with Sjögren’s.
Scientists have long wondered why age is a risk factor for Sjögren’s. The median age for diagnosis is 52, and women are nine times more likely than men to develop it.
The OMRF study determined that a particular white blood cell associated with aging proliferates and infiltrates the salivary glands in older mice, resulting in inflammation and loss of immune tolerance.
“We found that as normal mice age, many of them spontaneously get the same features we see in Sjögren’s disease in humans,” Bagavant said. “The aging process drives the inflammation in the glands.”
White blood cells generally circulate in the blood and lymph and create antibodies to protect our bodies against infection. In this study, the specific cell type also was found in various organs – a finding that raised more questions.
“The fact that we found them in the salivary gland, just spontaneously accumulating along with the presence of inflammation, tells us they must be doing something,” Bagavant said. “Figuring that out is our next step.”
Beyond their finding is a more universal idea for future research of Sjögren’s and perhaps other autoimmune diseases: Reliable results require age-appropriate research models.
In this case, this means using mice between 15 and 24 months old. Historically, scientists have used younger mice for drug testing.
“What our study suggests is that if you want to test a potential drug, and your target population is older humans, those drugs should be tested in age-matched animal models,” Deshmukh said. “As more research is done, I believe we’ll see a directive on this topic from the National Institutes of Health.” Their discovery was published recently in the journal Geroscience. The research was supported by grant No. DE032911 from the National Institute of Dental and Craniofacial Research, part of the NIH, and from Shared Instrumentation grant No. 1S10OD028479-01, also from the NIH, for the use of specialized equipment.

 

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