With the lifesaving potential of a bone marrow transplant comes an anxious few weeks of waiting to see if the patient begins producing new cells. A hematology oncologist at OU Health Stephenson Cancer Center is the co-leader of a national clinical trial that could revolutionize the field with an imaging technique that provides an early look at a transplant’s likely success or failure.

The clinical trial represents more than 15 years of work by Jennifer Holter-Chakrabarty, M.D., a bone marrow transplant physician at Stephenson Cancer Center. Her research was launched in response to the tragic outcome of a patient with leukemia who received a bone marrow transplant. She cared for the patient until the point when laboratory and clinical diagnostic techniques available at the time were able to determine if the bone marrow had repopulated. The transplant failed and the patient eventually succumbed to an infection and died.
Holter-Chakrabarty was determined to find a way to see, soon after a transplant, whether the bone marrow is growing. “That was the state of the science at the time – we didn’t have the diagnostic capability of predicting if a transplant would be successful,” she said. “It was very upsetting to lose my patient because I couldn’t tell whether her cells where growing. I am hopeful that this clinical trial will let us know early on whether a transplant is working, so that we can take different steps to intervene if needed. Waiting four to six weeks is too long.”
Holter-Chakrabarty’s research trajectory began after reading a publication by scientists in the Netherlands who had used a new imaging agent called fluorothymidine (FLT) in positron emission tomography (PET) for solid tumors like breast and lung cancer. In that case, FLT imaging provided an excellent view of the bones but a poor look at the breasts and lungs. Holter-Chakrabarty realized that those researchers’ problem was her solution – an imaging agent that could light up the bones to reveal whether marrow was growing.
FLT’s potential is in how it differs from the current standard imaging agent, FDG (fluorodeoxyglucose). Because FDG is tied to glucose, when used for imaging, it recognizes any cell that is active, whether dividing or because of inflammation. However, the thymidine in FLT only distinguishes cells that that are dividing – the exact behavior of a bone marrow transplant that is working as intended.
Holter-Chakrabarty first tested FLT imaging in the laboratory, where it allowed her to see bone marrow repopulating in mice whose marrow had been irradiated. She then tested it in a small clinical trial in bone marrow transplant patients who were at low risk of failure because of the similarity of the donor’s marrow. Again, that trial demonstrated that FLT imaging could accurately predict early marrow growth, as well as the safety of FLT.
In the current trial, Holter-Chakrabarty is testing FLT imaging in patients whose type of bone marrow transplant puts them at a 10-12% chance of failure. In particular, the patients have undergone cord blood transplants, which use donated cells from a mother’s placenta, and haplo-identical transplants, which are matched by half, usually siblings or parents of the recipient. Patients will undergo imaging one day prior to transplant, at five to nine days after transplant, and again 28 days after. In another cohort, patients who are not producing new cells by day 24 will undergo a single FLT image to determine whether the transplant is delayed or has failed.
The trial also will allow Holter-Chakrabarty to study different biomarkers to learn more about why some transplant recipients are more at risk for failure than others.
“The more we know about the biology of the process, like understanding which proteins are in particular places and what types of modifications occur in the cells, the more we can be very direct and prescriptive about how we make changes to help the patient early on,” she said.
The clinical trial, funded by the National Institutes of Health, will enroll 50 patients at three centers: OU Health, Emory University and the University of Michigan. Holter-Chakrabarty’s colleagues at the two other sites lead the project with her. If successful, the trial will mark a major leap forward for bone marrow transplant physicians and the blood cancer patients they treat. Patients whose bone marrow transplants fail only have a 30% survival rate over three years. Moving closer to improving those odds is gratifying, Holter-Chakrabarty said.
“It has been very exciting to reach this point,” she said. “To be able to see bone marrow growing in a human while you’re doing the transplant is a first for our field. This trial is addressing the very problem I faced when I lost my patient all those years ago, and it will provide hope for our patients in the future.”

By Nick Thomas

Before “Grease,” the hit 1978 movie, there was “Grease” the musical theater production first performed in Chicago in 1971 before moving to Broadway a year later for over 3,000 performances.
Adrienne Barbeau, who played Rizzo during the first five months of the show’s run, helped commemorate the 50th anniversary of the production as a co-editor of the 2022 book: “Grease, Tell Me More, Tell Me More – Stories from the Broadway Phenomenon That Started It All.” It features personal anecdotes from the Broadway cast and crew.
“It stemmed from a Zoom meeting that the original cast had when the pandemic first shut everything down,” recalled Barbeau from her home in Los Angeles. “The stories everybody told were just so delightful and touching and funny and most of them all new to me because I left the show early on.” (STORY CONTINUES BELOW)

Barbeau and two others involved in the production began assembling the stories.
“We sent out a questionnaire to over 100 actors, musicians, and crew members who had been involved in the show asking them to write down their stories of working on the production,” said Barbeau. “We put it all together in a terrific tribute to the show.”
Despite her strong connection to “Grease” which opened on Valentine’s Day, 1972, to this day Barbeau still has not watched the popular 1978 movie version which has many differences, including some of the music, from the original play.
“I happened to hear one of the songs from the movie a long time back, which was one of my songs,” she recalled. “It was lovely what they had done with it, but it just was not what we had done. So, I decided never to watch the film so I could keep the memory of our show and not cloud it with another version.”
Though her career began in musical theater, Barbeau left “Grease” to co-star in the TV comedy “Maude” throughout the 70s. But in the early 80s, the actress starred in several horror/sci-fi films (“Swamp Thing,” “The Fog,” “Escape from New York,” “Creepshow”) forever cementing her movie status as a horror sex symbol (see www.abarbeau.com).
“I started out in musical theater and comedy, and the transition to more dramatic roles was never by design,” Barbeau explained. “It’s just that somebody offered me something I wanted to do or needed to do to pay bills. I ended up playing strong women who were not victims and they were often interesting and challenging roles.”
“People always say, oh you were a sex symbol,” she adds. “But I like to remind them my first love scene in film was with a swamp monster!”

Nick Thomas teaches at Auburn University at Montgomery, in Alabama, and has written features, columns, and interviews for numerous magazines and newspapers. See https://www.getnickt.org/.

Dr. Elise Brantley, M.D.

Practicing for almost 15 years, Brantley established Scissortail Dermatology in 2021.

Story by Van Mitchell, Staff Writer

Dr. Elise Brantley, M.D., owner of Scissortail Dermatology, 3030 NW 149th in Oklahoma City, says one of the biggest concerns her patients have this time of year is dry, itchy skin.
“To improve dry skin, it is important to focus on restoring the quality of the top layer of the skin,” she said. “Use soaps/body washes only in areas that need deep cleansing such as under the arms or in the groin. Moisturizers are most effective after a shower or bath. Pat dry, but leave the skin somewhat damp in the areas that are the driest. Apply the moisturizer to damp skin, being careful not to slip. Many patients find it safest to do this step while sitting down.”
She said creams like CeraVe and Cetaphil are great examples of effective and well-tolerated cream moisturizers.
“Creams are more effective than lotions in keeping the skin moisturized,” she said.
Scissortail Dermatology was established in 2021, but Dr Brantley has been practicing for almost 15 years, over 10 of which have been in the OKC metro area. Her clinic provides care to both North and South OKC. She has several hobbies including creating quilting patterns, which she has turned into an online business.
“My mom was a quilter,” she said. “I wasn’t really that interested in it until I saw this random sampler, crazy quilt that was just wild. It blew my mind.” She dove into the craft and now sells quilt patterns online.
Brantley’s other hobbies of long-distance running, reading, and playing piano keep her busy.
“I took piano (before), but quit in sixth grade,” she said. Now as an adult, her 12-year-old daughter Isabella is following her path in developing her own piano skills. After seeing how much she enjoyed watching her daughter perform in recitals, her husband encouraged her to start taking lessons again at the same time. She and Isabella now enthusiastically perform side by side.
Brantley said her husband Steven, an orthopedic sports medicine physician, and her Scissortail team are the key to her ability to pursue her endeavors.
“My husband’s very supportive.” The staff in the clinic are highly efficient and organized, which allows her time to develop her other interests on her days off.
Brantley is board-certified and has been practicing dermatology since 2009. Her practice focus is evaluation and treatment of growths of the skin with emphasis on skin cancer.
She is a native of Broken Arrow, graduated high school from the Oklahoma School of Science and Mathematics, and attended the University of Tulsa for undergraduate studies.
She received her medical degree from the University of Oklahoma and completed her residency training at the University of Cincinnati where she served as chief resident.
While her husband was completing additional training in orthopedics, she served on the faculty of both the University of Cincinnati and Emory University in Atlanta, Georgia before returning to Oklahoma.
Brantley initially went to school to become OBGYN, but then did a dermatology rotation and was blown away at how fun it was to make a diagnosis.
“It was cool,” she said. “It’s fun to use your own visual skills to make diagnoses where you don’t always have to rely on labs. It’s just really fun to figure it out with your brain. It’s really fascinating to me.”
Brantley said diagnosing is a learned skill.
“We spend years learning a method of how to look at something (on the skin) and know what it is,” she said. She likens it to car enthusiasts being able to instantly recognize the make model and year of a car. She explains that learning to recognize a car by its characteristics such as bumpers, taillights, hood ornaments can become second nature to someone who observes them on a regular basis. “You just know you, and you don’t even think through why you know it. You just know it.” Brantley named her clinic Scissortail Dermatology to suggest something recognizable.
“I wanted something that felt comfortable and familiar,” she said. “I have scissortails on my kitchen wall, and I was Facetiming with my brother.” Brainstorming together for a name for the new clinic, he noted the bird hanging in the background. He suggested the name Scissortail and it stuck
Brantley said building a doctor-patient trust is important to her.
“It’s important for them to trust me that I have their best interests in mind,” she said. “I talk a lot to my patients about what kind of things interest them. We talk about their grandkids, we talk about their hobbies, we talk about their sun exposure, of course, what they’re doing outside. We actually catch up, they ask me about my daughter, I ask them about whatever projects they’ve been working on. If they’re quilters, we swap quilt pictures. I truly believe that’s the magic of what makes a practice like this work. I know them and they know me, and that builds a trusting relationship where we can actually make good decisions together. The fact that you can take care of someone through their lifetime is really appealing.”
For more information about Scissortail Dermatology call (405) 562-6222 or visit
www.Scissortaildermatology.com

The Oklahoma History Center (OHC) is seeking performers and vendors for its upcoming Folklife Festival to be held October 16, 2021, from 9 a.m. to 2 p.m. This community-wide event will celebrate and recognize what the American Folklife Center at the Library of Congress has called “the everyday and intimate creativity that all of us share and pass on to the next generation.” The “creativity” mentioned will come in the form of dancing, singing, crafts, food and much more. The Folklife Festival will be open to the public and held predominantly outdoors at the OHC, located at 800 Nazih Zuhdi Drive in Oklahoma City.
Already scheduled to participate are: Oklahoma Farm Bureau; Angels Modeling and Dance Studio; Eterna Primavera Folklore Guatemalteco; Southwest Dairy; “Traditional Music of the Open Prairie” with Wayne Cantwell; 3J Farms; 145th Army Band; and Thick Descriptions. Also, the Oklahoma Pork Council will be giving away a new roaster/smoker.
If you are interested in participating in the OHC’s Folklife Festival as a performance act or vendor, please complete the application form found at www.okhistory.org/historycenter/folklifesignup.
The Oklahoma History Center is a division of the Oklahoma Historical Society and is an affiliate of the Smithsonian Institution, National Archives and is an accredited member of the American Alliance of Museums. The mission of the Oklahoma Historical Society is to collect, preserve and share the history and culture of the state of Oklahoma and its people. Founded in 1893 by members of the Territorial Press Association, the OHS maintains museums, historic sites and affiliates across the state. Through its research archives, exhibits, educational programs and publications the OHS chronicles the rich history of Oklahoma. For more information about the OHS, please visit www.okhistory.org.

Chronic pain can be quite common among older adults as they face conditions such as arthritis and neuropathy. Treating pain in older adults requires special considerations, however, especially when it comes to opioids.
The University of Oklahoma Health Sciences Center recently received a $2.5 million federal grant to tailor methods of treating chronic pain to the older adult population – with an emphasis on decreasing the use of opioids – and to disseminate those best practices to primary care clinics across Oklahoma. The grant is from the Agency for Healthcare Research and Quality, the lead federal agency charged with improving the safety and quality of America’s healthcare system.
In recent years, the OU Health Sciences Center has made significant contributions to the medical profession’s understanding of the risks and benefits of using opioids to treat chronic pain. However, much of that work has focused on the general population, rather than older adults specifically. This grant will allow physicians and researchers to concentrate solely on older adults, and to establish standards of pain management that prioritize non-opioid medications and treatments.
“The older population has a much different relationship with opioids than the younger population does,” said one of the grant’s three principal investigators, Zsolt Nagykaldi, Ph.D., Director of Research for the Department of Family and Preventive Medicine in the OU College of Medicine. “In the younger population, the No. 1 problem is typically misuse, while in the older population, the bigger problems are interactions between opioids and other medications and other health conditions, as well as a higher risk of falls.”
There are numerous reasons for limiting or avoiding opioid prescriptions in older adults, said co-principal investigator Steven Crawford, M.D., Senior Associate Dean for the OU College of Medicine. Metabolism slows as people age, which can increase the effects of opioids. Conditions like emphysema and sleep apnea complicate the use of opioids, Crawford said, and other medications may interact poorly with opioids. Opioids also cause constipation, which can affect the body’s systems and eventually lead to serious issues.
However, there are many alternatives to opioids. Non-opioid medications may be an option, although care must be exercised with anti-inflammatory drugs like ibuprofen, which can damage the kidneys and increase the risk of internal bleeding, among other complications, Crawford said. There are many non-pharmacologic possibilities, such as physical therapy, topical agents, acupuncture, massage, meditation and exercise. Those are also important options if patients are decreasing their opioid use slowly over time.
“Regular physical activity is very important for managing chronic pain because pain gets worse if people sit for a long time,” said geriatrician and co-principal investigator Lee Jennings, M.D., Chief of the Section of Geriatrics in the Department of Medicine, OU College of Medicine. Jennings is also director of the Oklahoma Healthy Aging Initiative (OHAI), which provides gentle exercise opportunities and falls prevention classes (including via Zoom) across Oklahoma. OHAI’s free programming will be emphasized as part of the overall program.
“It’s not easy to treat older adults with chronic pain, so this grant will allow us to help patients and their physicians to understand and have access to alternatives to opioids,” Jennings said. “It’s very important to have safe opioid prescribing practices and to make sure that patients understand the risks, but we have to think through other ways to manage pain. It’s not always possible to make someone totally pain-free, but we also don’t want to put someone at risk for a fall because they’re taking a medication that has a sedating effect. We want them to continue doing the activities that enrich their lives. We don’t want people to stop doing the things they enjoy because that can lead to social isolation and loneliness, which ultimately leads to poorer health.”
Because primary care clinics provide most of the care for older adults with chronic pain, the OU Health Sciences Center will be working with up to 50 clinics across Oklahoma. Community panels, comprised of both patients and clinicians, will provide insight into the needs specific to each area. The OU Health Sciences Center has an extensive network of relationships with rural clinics across the state to share best practices and provide hands-on assistance; this grant will enable further outreach on a topic that’s important to many Oklahomans.
“New medical guidelines, if they follow the natural course of things, can take years to become wedded into the practices of clinics,” Crawford said. “This type of program allows us to accelerate that process by working with clinics to improve the quality of life for their patients.”

by Steven Sibley, Ret Army, DAV

Memorial Day has just passed and I want to salute all those who took the time to commemorate those who gave the ultimate sacrifice for our country. Since 1775, records indicate that as many a 1.3 million lives have been lost by those who served in our country’s military. That is basically the population of Tulsa, Edmond, OKC, Moore and Norman combined. Imagine, almost half of them died in a senseless civil war that took nearly half those lives. The Civil War started because of uncompromising differences between the free and slave states over the power of the national government to prohibit slavery in the territories that had not yet become states. For those who fought for freedom for all, there was a familiar ring back to the words of Patrick Henry in March of 1775, “Why stand we here idle? What is it that gentlemen wish? What would they have? Is life so dear, or peace so sweet, as to be purchased at the price of chains and slavery? Forbid it, Almighty God! I know not what course others may take; but as for me, give me liberty or give me death!” The price of freedom for all is that great, that precious.
Our veterans have not only died, many have been wounded, maimed for life, and scarred both physically and emotionally. While complete statistics were difficult to find on this subject, it appears that on average, for every veteran killed, up to 10 were wounded. That is a significant number. It is why it’s so important for us to do the very best we can, to take care of our veterans. The heroic 1% of our population. This is one of the greatest needs we have as a country. It’s the greatest reason for those who are the top 1% of income earners in our country, to freely and responsibly give, in whatever way they can or must, to support these heroes, who have sacrificed so much for others to have the opportunity and freedom to succeed in our country at the highest levels.
Soon it will be Independence Day, 2021. This is my challenge to those who would seek to honor both those who have given their lives and those veterans who have been injured or disabled in the service of this country. Between July 4th this year and November 11th, Veterans Day, for those 5 months, would you purposely and proactively reach out to at least 1 veteran a month, and tell them you appreciate their service, and then serve them in some way. What ever you feel led to do, send them a card, buy them a meal, mow their lawn, take them to an appointment or just have a conversation with them. Imagine if everyone in Tulsa, Edmond, OKC, Moore and Norman reached out to just 5 veterans, that would be over 5 million times a veteran was talked to, recognized, appreciated and helped.
As a retired, disabled veteran myself, my wife and I do our part by helping veterans who transition into Medicare. We help them understand how those benefits work with their VA Benefits and Tricare Benefits. We provide support, advocacy and information about Medicare Plans offered by companies that have special plans for veterans, that offer additional benefits which they’ve earned and deserve. While healthcare issues and delivery of healthcare is confusing enough for seniors, it is even worse for veterans who have sacrificed their bodies and blood only to find red tape and bureaucracy standing in the way of the healthcare they desperately need. If you need our help, just call, there is never any charge, any pressure, just help. We are here to serve you at www.Sibleyinsures.com, (918) 404-0807.