Last month, Sen. John McCain died from glioblastoma, a form of brain cancer. The same disease took the life of Sen. Edward Kennedy.
But here in Oklahoma, Norman’s Mike Schuster continues to live with the disease. As he nears the three-year anniversary of his diagnosis with the deadly cancer, he’s already doubled the life expectancy for patients with glioblastoma.
Doctors can’t say why Schuster has lived where others have succumbed to the disease. But they believe it may be because of an experimental drug he received—one that was developed by scientists at the Oklahoma Medical Research Foundation.
For Schuster, the first clue that something was awry came in the fall of 2015, just past his 50th birthday. While at work, he passed out with no warning.
He was rushed to the hospital, where an MRI revealed a brain tumor the size of a kiwi just above his right eye. “I’d been healthy all my life,” Schuster said. “No medical issues at all. I just couldn’t believe that this was happening.”
Of the more than 120 types of brain and central nervous system tumors, Schuster’s type, known as a glioblastoma, is the most aggressive. The standard treatment regimen involves surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy. Still, the tumor almost always grows back.
With treatment, the median survival—which means half of patients live longer, and half die sooner—is 12 to 18 months. Only 1 in 20 glioblastoma patients will live five years.
In a procedure that lasted six hours, doctors removed as much of Schuster’s tumor as they could. When Schuster regained consciousness, his surgeon explained that he’d succeeded in excising most of the tumor. But, he said, like most glioblastomas, this one had “tentacles.” Tiny arms of the tumor had grown into surrounding brain tissue and could not be removed.
Schuster began follow-up radiation treatment at the Stephenson Cancer Center at the University of Oklahoma. Even though Schuster couldn’t feel the electromagnetic waves pulsing through his brain, “you could smell it,” he said. He also started chemotherapy, taking a pill called temozolomide. Together, the treatments were intended to kill the tumor cells that remained in the fissures of his brain.
“If you leave even a single cancer cell in the brain, it can regrow,” said Dr. James Battiste, the neuro-oncologist who oversees Mike’s care at Stephenson. “The brain is fertile soil for these tumors. That’s why chemo and other therapies are so important.”
Following radiation—doctors limited his treatment to six weeks for fear of triggering a secondary cancer—Schuster stayed on temozolomide. But just after the one-year anniversary of his diagnosis, an MRI revealed a new tumor.
A second surgery once again removed the primary tumor. This time, doctors kept Mike awake throughout the procedure to ensure they didn’t damage crucial areas of his brain. Still, many glioblastoma tentacles had escaped surgeons’ reach, remaining lodged in Schuster’s brain.
Schuster knew those tentacles were, in essence, seeds that could sprout another full-blown tumor in a matter of weeks. He told Battiste he was willing to try anything to beat back the glioblastoma. He’d read about clinical trials of experimental medications. Was there one that might help him?
Battiste, in fact, was testing a new drug that, he said, “just seemed suited for Mike.” It was an investigational medication for glioblastoma that had been born just down the block from Stephenson, in the labs of the Oklahoma Medical Research Foundation.
Known as OKN-007, the experimental medication was discovered by OMRF scientists Drs. Rheal Towner and Robert Floyd. In pre-clinical glioblastoma experiments, the compound dramatically decreased cell proliferation (spread) and angiogenesis (formation of new blood vessels), and it turned on the process of removing damaged cells so they can’t become cancerous.
“Those are the three major factors needed in a cancer drug,” Towner said. “This compound seemed to do all of them.”
Oblato, Inc., a New Jersey subsidiary of Korean biotechnology company GTreeBNT, has acquired the rights to OKN-007 from OMRF. It will move ahead with further trials of the drug in glioblastoma.
At Stephenson, Battiste has been cautiously optimistic about the performance of OKN-007 in Schuster and his other patients. “We’ve gone to the highest dosage levels the FDA would allow, and we haven’t seen any negative effects from the drug.” Although evaluating the medication’s effectiveness at stopping the regrowth of tumors is not a primary focus of the early phases of the trial, “it’s helpful to see things looking good” on this front, too, he said.
In August, Schuster celebrated his 53rd birthday. When he sees other patients with brain tumors, he said, they appear thin and frail. He, on the other hand, has added 15 pounds since beginning OKN-007 infusions. “I’ve had no side effects at all,” he said. “I’ve also been able to get back to the gym and am doing some yard work. I feel really good.”
He continues to travel to Oklahoma City each week for infusion treatments with OKN-007. “I really appreciate all of the support we’ve received from Stephenson and from people at OMRF,” he said.
While fighting glioblastoma has brought numerous challenges, Schuster said the experience has also revealed silver linings. “My friends and family and their prayers for me have turned into blessings.”
Of course, neither Schuster nor his doctors can know for sure if the drug is responsible for keeping his cancer at bay. Nor can they say if, or when, the disease might recur. “I can’t worry about stuff,” Schuster said, “that’s out of my control.”
Still, he feels certain he made the right decision when he opted to participate in the clinical trial. “Let’s just say I’ve been very blessed. It’s pretty cool how this stuff is working.”

Travel through history and be entertained at the 2018 Oklahoma History Center Conference.

Photography and Text by Terry “Travels with Terry” Zinn t4z@aol.com

You don’t need to physically travel to a far away destination to be informed and entertained. This year the Oklahoma Historical Society offers its 125 th annual History Conference at the Oklahoma City location of the Oklahoma History Center, April 25, 26, and 27. The three day conference features three tours, two luncheons and one reception and one concert, of the musical, “Oklahoma.”
Headlining the presenters will be Ted Chapin, president of the Rodgers and Hammerstein organization in New York, and David Grann, author of “Killers of the Flower Moon: The Osage Murders and the Birth of the FBI.” Dick Pryor, general manager of KGOU will serve as emcee of the annual awards luncheon on Friday, April 27, at noon. The awards luncheon will celebrate accomplishment in Oklahoma history and induct four people into the Oklahoma Historians Hall of Fame.
The other presenters will speak during the course of 18 presentation sessions. The Thursday speakers include Mark Janzen, Edmond, Jonita Mullins, Muskogee, Jan Davis, Oklahoma City, Kitty Pittman, Oklahoma City, Michael Hightower, Oklahoma City, Christopher H. Owen, Tahlequah, Jeanetta Calhoun Mish, Oklahoma City, John Thomas Truden, Norman, and Mark Dolph, Tulsa.
Making presentations on Friday will be Rusty Willliams, Dallas, Texas, Sydney Stover, Cheyenne, Davis D. Joyce, Spavinaw, Kathryn Shurden, Henryetta, Craig Corgan, El Reno, Landry Brewer, Sayre, Chester Cowen, Norman, T. S. Akers, Oklahoma City, Bob Blackburn, Oklahoma City, John Bedford, Oklahoma City, Mark Parker, Oklahoma City, and Jo Rowan, Oklahoma City.

On Thursday, April 26, the Oklahoma Historical Society will partner with Oklahoma City University to celebrate the 75th anniversary of the Broadway debut of “Oklahoma!” OCU students will perform songs from the musical and the first iteration “Green Grow the Lilacs” written by Oklahoman Lynn Riggs. The event will feature a special video by Broken Arrow native Kristen Chenoweth, who participated in the 50th anniversary of “Oklahoma!” as an OCU student. This performance is open to the public and tickets can be purchased by calling 405-522-0317. 6:30–8:00 p.m. An additional program is being offered called, Celebrating Oklahoma! at 75, in celebration of the musical’s 75th anniversary, this program will trace the story of Oklahoma! and its influence on musical theater. The event will feature performances by students from the Oklahoma City University Wanda L. Bass School of Music.
Also, on Thursday, April 26, the OHS will sponsor a bus tour of ‘89er landmarks in Oklahoma City led by Chuck Wiggin. Other tours include a tour of the State Capitol restoration by Capitol Project Manager Trait Thompson and a Behind-the-scenes tour of the Oklahoma History Center.
On Wednesday April 25th the registered public is invited to a reception from 5 to 7 p.m.,at the Oklahoma Judicial Center, formerly the home of OHS.
Ted Chapin, the president of the Rogers and Hammerstein Organization, New York City will present, “The Legacy of Oklahoma!” at 9 am on April 26th.
At noon, at the Annual Conference Luncheon,Keynote speaker David Grann, author of “ Killers of the Flower Moon: The Osage Murders and the Birth of the FBI,”will present the background making of the popular book.
Sessions on Friday will include talks on, “ “The Red River Bridge War: When the Boundary between Oklahoma and Texas Became an Armed Camp, “The Art of War on the Washita,” and “The Origins of Freemasonry in Oklahoma,” by T. S. Akers, curator of collections, McAlester Valley of the Ancient and Accepted Scottish Rite, Oklahoma City, among others. A complete listing of topics and speakers are available at Okhistory.org.
The mission of the Oklahoma Historical Society is to collect, preserve and share the history and culture of the state of Oklahoma. Founded in 1893 by members of the Territorial Press Association, the OHS maintains 31 museums, historic sites and affiliates across the state. Through its research archives, exhibits, educational programs and publications the OHS chronicles the rich history of Oklahoma. For more information about the OHS, please visit www.okhistory.org.
To attend and hear your selection of nineteen different speakers, and tours and luncheons, you must register by April 20th, either on line at www.Okhistory.org, or by contacting Larry O’Dell at 405-522-6676 or lodell@okhistory.org or Shelly Crynes at 405-522-0317 or scrynes@okhistory.org.

by Tara Vreeland

Senior residents rom The Villages at Southern Hills, collected donations for Emergency Infant Services over the holiday season. The residents chose EIS because they wanted to give back to the community and thought it was a good idea after seeing a donation box at the facility. They collected new/gently used baby/toddler items like diapers, bassinets, wipes, clothes, toys, blankets, and strollers. A few of the residents, staff with Lifetime Wellness and social worker, Caitlyn Morgan paired with the Eastside Christian Church Youth Group to collect the times. They boarded a bus to deliver the items to EIS and were personally greeted by Executive Director, Tim Gowin.
Gowin says, “Our agency is pretty much 100% grassroots Tulsa. Donations like this are what make our agency tick. It is the way we are able to serve.”
The residents were able to visit with Gowin and he says they genuinely expressed interest in EIS and its mission. “I could feel the connection with them. And you could see it on their faces. They were very proud to be able to help. They should be proud.” One Villages at Southern Hills resident said, “I didn’t realize there was such a need for the items. I love the cause and am amazed it has no state or local grants behind it.”
Gowin says last year, they served 18,800 children between the ages of 0-5 thanks to generous donations from the community. He also says the items the residents donated were processed the next day and have already been distributed.
Gowin says right now, EIS is in need of volunteers to help serve families. He also says this time of year, there is a need for winter coats for kids 0-5… specifically the middle sizes 24 months 2T and 3T. For more information visit http://www.eistulsa.org/or contact volunteer coordinator Kimberly Deardorff directly at kimberly@eistulsa.org or call 918-582-2469 for any additional information or questions.

Mozart: From Salzburg to Vienna

The Brightmusic Chamber Ensemble will present its fifth and final regular-season concert, Mozart: From Salzburg to Vienna, Tuesday, April 16, at 7:30 p.m. This all-Mozart evening will feature his most popular work, Eine kleine Nachtmusik.
Mozart’s String Duo No. 1 in G (K. 423) for violin and viola was written when the child-genius was only 17 to help out a colleague—Joseph Haydn’s brother, Michael—who was unable to complete a commissioned work due to illness. By this time, Mozart had been composing for over a decade so, though it is a youthful work, it does not lack maturity. Like Eine kleine Nachtmusik, the Quintet for Clarinet and Strings in B-flat (K. Anh. 91), for two violins, viola, cello and clarinet, was published after the composer’s death at the early age of 35. The quintet, like a number of Mozart’s later works, was finished by another, in this case, the renowned Mozart scholar R.D. Levin. The program will include Mozart’s enchanting violin sonata No. 24 in B-flat (K. 378/317d), transcribed for clarinet quartet (violin, viola, cello and clarinet).
Capping the evening is a work that has long been considered Mozart’s best loved, his serenade Eine kleine Nachtmusik—literally “A Little Night Music” (K. 525) for two violins, viola, cello and double bass. This work was among a bundle of manuscripts that Mozart’s young widow took to a publisher hoping to generate some badly-needed cash. Though it is thought to be missing a movement, there is plenty of charm in the surviving four movements.
Musicians appearing in this concert are: Gregory Lee and Katrin Stamatis (violin), Samuel Formicola (viola), Meredith Blecha-Wells (cello), George Speed (double bass) and Chad Burrow (clarinet).
Brightmusic Chamber Ensemble, Oklahoma City’s own chamber ensemble, presents fine classical chamber music in the beautiful and acoustically-rich St. Paul’s Cathedral at 7th and N. Robinson near downtown Oklahoma City. Tickets are $20 at the door. Children, students and active-duty military personnel admitted free with ID. Free parking south of the cathedral. For more information, visit us at www.brightmusic.org

The Oklahoma City Community Foundation recently awarded $97,500 to six charitable organizations in central Oklahoma providing services for elderly citizens.
“Seniors are in need of programs that help them to live happy, healthy lives,” says Whitney Moore, development director for recent grant recipient Oklahoma City Ballet. “Remaining active as seniors age is very important in maintaining their independence and health.”
The Community Foundation’s Services for the Elderly iFund program supports organizations that provide direct services for our community’s older citizens who still live in their homes. By supporting wellness and exercise activities, this program helps to allow independent living to continue and provides positive social and recreational opportunities improving their quality of life.
“Oklahoma City is continually listed as one of the nation’s least healthy cities. The Oklahoma City Community Foundation is actively working to change this by creating a culture of health and wellness in central Oklahoma,” Oklahoma City Community Foundation President Nancy B. Anthony said. “We are pleased to work with charitable organizations that share our vision and provide creative solutions to improve the lives of citizens in our community.”
The following grants were awarded through the Services for the Elderly iFund:
American Red Cross of Central Oklahoma – $12,500 for a campaign to prevent home fires among elderly residents.
NewView Oklahoma – $20,000 for a medication management program for seniors who are vision-impaired.
Oklahoma City Ballet – $10,000 for the Golden Swans program providing ballet classes to help improve senior mobility.
Rebuilding Together OKC – $20,000 to provide critical heating, cooling and electrical repairs to low-income seniors allowing them to remain safe, warm and dry in their homes.
Regional Food Bank of Oklahoma – $20,000 to provide nutritious food and healthy living resources to low-income seniors.
The Salvation Army Central Oklahoma Area Command – $15,000 to support the Senior Watch program that provides immediate, short-term assistance for seniors in need of additional household, emotional or spiritual support.
An initiative of the Oklahoma City Community Foundation Trustees, the iFund program utilizes gifts from donors to support services for children and elderly, as well as provide access to health care. Since 2011, the iFund program has awarded more than $2.5 million to charitable organizations serving central Oklahoma. For more information, visit www.iFundokc.org.
Founded in 1969, the Oklahoma City Community Foundation is a 501(c)(3) public charity that works with donors to create charitable funds that will benefit our community both now and in the future. To learn more about the Oklahoma City Community Foundation, visit www.occf.org.