In the process of aging, many older adults bear the heavy burden of dementia and vascular cognitive impairment, conditions that can rob them of quality of life and put them at risk for falls and injuries. To explore a promising premise in aging research — that changes to the brain’s tiniest blood vessels may play an outsized role in cognitive decline — an OU College of Medicine researcher recently received a $1.7 million grant from the National Institutes of Health.
Shannon Conley, Ph.D., an assistant professor in the college’s Department of Cell Biology and a research member of the Oklahoma Center for Geroscience and Healthy Brain Aging, earned the five-year grant, which will allow her to further explore how damaged micro-vessels in the brain may contribute to cognitive decline.
“It has become increasingly evident over the past 10 to 15 years that the smallest blood vessels are important in terms of contributing to disease pathology,” Conley said. “In the brain, this is especially important with aging. Because the brain can’t store any extra oxygen, the loss or damage of even a few tiny blood vessels means there’s not enough oxygen being supplied. In this project, we want to understand what is causing the damage or loss of blood vessels in the brain of an older adult.”
Specifically, Conley is focusing on the relationship between IGF-1, a common growth hormone that promotes blood vessel health, and smooth muscle cells, which surround the outside of blood vessels and help regulate blood flow by contracting and dilating. Researchers know that a person’s IGF-1 levels decline with age and that a deficit of the hormone can lead to defects in blood vessels. However, much less is known about the role of smooth muscle cells in that process.
“The research community has not really looked at the role of IGF-1 deficiency on the smooth muscle cells, specifically in the brain and in the context of aging and age-related cognitive impairment,” Conley said.
For this project, Conley has created an animal model that does not have a receptor for IGF-1 in the smooth muscle cells, resulting in a research model that mimics accelerated aging. Her first aim is to chronicle what happens when the smooth muscle cells can’t respond to IGF-1. Potential effects include damage or loss of blood vessels and impairment of the blood-brain barrier. She will also monitor to see whether the smooth muscle cells become impaired in their ability to contract as they normally do.
“One of the things that is important about smooth muscle cells in the brain is that they contract to protect the small blood vessels from the effects of systemic hypertension,” she said. “If you have systemic high blood pressure, you don’t want the tiny blood vessels in the brain to experience that. They’re very fragile and could have small bleeds or hemorrhages. So we’ll be watching to see if the smooth muscle cells lose their ability to protect the small blood vessels.”
Conley’s study will also seek to determine what is happening on a molecular level when smooth muscle cells cannot respond to IGF-1. “For example, do we see changes in the genes that are associated with cell contraction? Do we see early death of smooth muscle cells?” she said.
Ultimately, one of her goals it to identify targets that might be suitable for a therapeutic intervention. Treating an IGF-1 deficiency isn’t as simple of giving someone a supplement of IGF-1; because it is a growth factor, it could promote abnormal growth in other tissues and cells. However, some of the changes that occur because of IGF-1 deficiency could be a target for future treatments, she said.
Conley’s research is a component of the growing discipline of geroscience research, the study of the biology of aging. Aging itself is one of the biggest risk factors for disease, and many of the cellular mechanisms of aging are common across a wide range of pathologies.
“The things that go wrong in the blood vessel cells in the brain that can lead to dementia are some of the same things that can go wrong in the retina and lead to age-related macular degeneration. And some of those same cellular mechanisms can contribute to the development of Alzheimer’s disease pathologies or Parkinson’s disease pathologies. Among geroscience researchers, there is a lot of interest in what we call the basic cellular mechanisms of aging. We’re not looking specifically at the disease, but how the cells change as we age, and how that increases our risk for a variety of pathologies.”
As people live longer, research like Conley’s is especially important. Medical advancements may be able to keep people alive longer, but many will be diagnosed with conditions that significantly decrease their quality of life.
“As we have longer life spans, it’s really important to identify ways to simultaneously promote increased health spans,” she said. “It’s very challenging when you have loved ones who have severe illness or cognitive impairment, yet they are not dying; they are physically able to keep living. We want to help people stay healthier longer.”
Research reported in this news release is supported by the National Institute on Aging, a component of the National Institutes of Health, under the award number 1R01AG070915-01A1. Federal funds were secured with the help of seed grants from the Presbyterian Health Foundation, the OU College of Medicine Alumni Association, and the Oklahoma Center for the Advancement of Science and Technology.

Connect with wildlife and friends during these one-of-a-kind events occurring every third Thursday, April through September. Sip and Stroll tickets on sale now.

Plan your Thursday nights around spectacular sunsets, cool cocktails and wondrous wildlife with the Oklahoma City Zoo and Botanical Garden’s third annual, adult-only evening event series, Sip and Stroll. Presented by COOP Ale Works, Sip and Stroll occurs every third Thursday beginning April 21 and continuing through September 15, from 6-10 p.m. Revelers 21 and older are invited to explore the majority of the Zoo to discover amazing animals and exclusive experiences while savoring delicious drinks inspired by exotic wildlife and wild places throughout the night.
Sip and Stoll features six watering holes with three brand-new locations that highlight the OKC Zoo’s conservation projects both locally and globally. Guests will discover custom cocktails such as The Long Neck and Spotted In Namibia at these wildly themed drink locations that focus on destinations including Madagascar, Tanzania and Namibia. While visiting each watering hole, guests will have an opportunity to learn more about what the Zoo is doing to protect and preserve the natural world through global conservation partnerships with the Wildlife Trafficking Alliance, Cheetah Conservation Fund and others.
“Sip and Stroll continues to grow in popularity and is becoming an event favorite among our adult patrons,” said Jenna Dodson, OKC Zoo’s events manager.
There are more things to see and do while sipping and strolling through the Zoo! Sip and Stroll admission provides attendees with access to a variety of exclusive Zoo attractions including a sea lion presentation, Stingray Bay, the Endangered Species Carousel, an elephant presentation, karaoke, lawn games and more. With each Sip and Stroll event, guests can also get up-close to the Zoo’s gentle giants and partake in the giraffe feeding experience for an additional $5/person. Capacity is limited for these attractions so guests are encouraged to plan accordingly.
The Zoo also has specially scheduled entertainment for select Sip and Stroll evenings with dueling pianos on April 21 and August 18; a drag show for PRIDE Night on June 16; a DJ on May 19 and July 21, and a special live entertainment set on September 15.
2022 Sip and Stroll dates: Thursday, April 21, Thursday, May 19, Thursday, June 16 (PRIDE night with special drag show), Thursday, July 21, Thursday, August 18 and Thursday, September 15.
Event admission to Sip and Stroll is $32/person for non-members or $27/person for ZOOfriends members and online reservations are required. Tickets are available now at www.okczoo.org/sipandstroll. Sip and Stroll Drink Passports will be available for purchase for an additional $27 per person, allowing pass holders to enjoy a 5 oz. sample of all 6 specialty drinks. Drinks will also be available a la carte. Additional beverages and food will be available for purchase during Sip and Stroll from Zoo restaurants and local food trucks. Sip and Stroll tickets are non-refundable and non-transferable. This event will occur rain or shine. To purchase tickets or learn more visit www.okczoo.org/sipandstroll.

by Greg Schwem

“Hello! Thank you for downloading our app, which is guaranteed to take up valuable memory on your phone and ensure that, if you ever have a problem with our company, you now have the tools to solve it yourself. Which is why, on our website, you will not find any kind of contact information; only the sentence, ‘Most issues can be solved by downloading our app.’”
“First, we need a user name. Sorry, that name is not available. Nor is that one. Or that one. ‘Bootyliciousgranddad’? As weird as it sounds, even that one has been taken. ‘Greg79450854’ is available. Congratulations.”
“Now, please enter a password. It must contain one capital letter, one number, one special character you never knew existed on your keyboard, and another special character you create simply by pressing, simultaneously, ‘control/option/shift/return/command/function/tab/CAPS LOCK/>/<.’”
“That password is weak. Please try something stronger. May we suggest, ‘Pwb8*)@?!sV’?”
“Now, please re-enter the password. Sorry, the passwords didn’t match. Please check the spelling and be reminded that certain characters do look alike, particularly the ones we suggested for you.”
“Success! If you have not yet thrown your phone against a wall in anger, you are ready to use our app. Almost. First, we need to verify that you are you and not some robot that is capable of completing the user name and password steps. Please retype the following characters: 0oO1liImnmmnmnnOo0.”
“Please click here to request another series of characters that look like they came from an eye chart at your optometrist’s office. You have four more attempts.”
“Whew. You did it on your last try. Way to go! Now you just need to click on every square containing the color white.”
“Try this one. Click on every square where you see a road.”
“Close enough. You have successfully installed our app. Now, please download the latest version, 15.0.7.3.2, which we released while you were trying to find the roads. Please close all other apps on your phone while the installation takes place. The new version will be installed in approximately 13 minutes. Or three hours. Or two days if your internet connection sucks.”
“Your app is now up to date. You may sign in.”
“First, we need your credit card information and a scanned government issued ID. This could be a passport, driver’s license, Social Security card or anything else that could make your life a living hell if hackers stumble across it. But that isn’t going to happen. Rest assured; we NEVER share your personal information with outside sources. And we’re serious. That’s why we capitalized ‘NEVER.’”
“Now it’s time to link your credit card information to your digital wallet. Click here to establish a digital wallet. You might want to walk away from your phone for a few minutes, because establishing a digital wallet means creating another user name, password and avatar. Spend this time away from your phone by going to another device and Googling, ‘What is an avatar?’ Or just beat your head against a wall.”
“Make sure you store your digital wallet login information separately from where you keep your other password information. If you cannot access your digital wallet, you will NEVER be able to retrieve the funds you placed there during a night of drinking with your friends because Steve told you it was time to start investing in cryptocurrency. By the way, Steve did not offer to pick up the check. What does that tell you about crypto?”
“Please check your inbox for a verification email. Simply click the link and you will be able to use our app. If the email does not appear between 30 seconds and 24 hours, please check your spam folder. If you do find the email in your spam folder, please add our address to your ‘contacts’ folder so we can send you periodic updates about changes to the app. If you have questions, our chat bot is here to help.”
“Please be advised that our chat bot only knows how to say, ‘Refer to your app.’”
(Greg Schwem is a corporate stand-up comedian and author of two books: “Text Me If You’re Breathing: Observations, Frustrations and Life Lessons From a Low-Tech Dad” and the recently released “The Road To Success Goes Through the Salad Bar: A Pile of BS From a Corporate Comedian,” available at Amazon.com. Visit Greg on the web at www.gregschwem.com.
You’ve enjoyed reading, and laughing at, Greg Schwem’s monthly humor columns in Senior Living News. But did you know Greg is also a nationally touring stand-up comedian? And he loves to make audiences laugh about the joys, and frustrations, of growing older. Watch the clip and, if you’d like Greg to perform at your senior center or senior event, contact him through his website at www.gregschwem.com)

After a national search, INTEGRIS Health is excited to share the selection of Brent Hubbard as the health care system’s new chief operating officer.
Hubbard comes to INTEGRIS Health most recently from Mercy Health System, Mercy Hospital Springfield Communities, where he serves as president and COO. Since 2016, his responsibilities were to lead the strategic direction of seven hospitals with administrative and operational oversight of 7,500 coworkers.
Prior to Hubbard’s current position, he served as the chief operating officer at Mercy Health System, Mercy Hospital Fort Smith Communities, and the chief operating officer at HCA, Medical Center of McKinney. Other roles he has held include associate administrator at HCA – Centennial Medical Center and executive director and director of marketing at Woodward Regional Hospital.
Hubbard received his Bachelor of Science in business administration from Oklahoma State University and his Master of Business Administration from Southwestern Oklahoma State University. He is an accomplished health care executive and brings to INTEGRIS Health a strong focus on performance metrics. He is a believer in continuous process improvement. Hubbard has extensive experience in improving physician and coworker engagement, quality measures and patient outcomes, and achieving operational excellence to include service line growth and expanding patient access to health care.
He and his wife, Hilary, were both raised in Oklahoma, Mooreland and Woodward respectively. They are excited to be moving, along with their three children, back to the great state of Oklahoma and joining the INTEGRIS Health team. Hubbard’s first day at INTEGRIS Health will be May 2.

Since 1951 the cannon used by William “Buffalo Bill” Cody and Gordon W. “Pawnee Bill” Lillie in their Wild West Show has been on display at the Oklahoma Historical Society (OHS) headquarters in Oklahoma City. It was first displayed outside the original OHS building at 2100 N. Lincoln Blvd., and then at the new Oklahoma History Center at 800 Nazih Zuhdi Drive. After more than 70 years in Oklahoma City, the cannon will return to the Pawnee Bill Ranch and Museum in Pawnee.
According to Ronny Brown, the Pawnee Bill Ranch and Museum director, the Model 1861, 3-inch ordnance rifle was cast in 1863 at the Phoenix Iron Company in Phoenixville, Penn. The gun reportedly saw service in several Civil War battles, including Missionary Ridge, before Pawnee Bill acquired it for use in the Wild West Show. After the Wild West Show, the gun found a home on the front lawn of Pawnee Bill and May Lillie’s mansion. Shortly before Pawnee Bill died in 1942, he gifted the gun to his longtime friend and publicist Frank Stuart. The carriage was in bad shape and continued to deteriorate as the gun sat in Stuart’s backyard in Oklahoma City for many years. Stuart died in 1950, and under his will the cannon was gifted to the OHS in 1951. The OHS had a new carriage built for the cannon, and has displayed it in Oklahoma City ever since. Now the gun is set to return home to the front lawn at the Pawnee mansion.
The OHS is providing $15,000 in matching funds toward the $30,000 needed to restore the carriage, build a suitable exhibit space, and move the cannon to Pawnee. “This has been a dream of the local community for many years, and we are so excited to be working on plans to make it happen,” said Mona Denney, president of the Pawnee Bill Ranch Association. “We are launching a fundraising drive to raise the $15,000 needed to complete the project. This will be a big attraction for the ranch, and we can’t wait to see it back home on the mansion lawn.”
“We are very pleased to be working with the community of Pawnee to bring the cannon back to the ranch,” said Trait Thompson, executive director of the OHS. “The project includes placing a flagpole near the cannon and lighting the front of the mansion and the cannon display. The cannon will be placed on a concrete pad with exhibit panels to tell the cannon’s story. Also included in the project is a new sidewalk to ensure the display is accessible to everyone,” continued Thompson.
“Come by for a visit and make a donation to the project to be a part of this opportunity,” said Denney. “If you can’t make it for a visit, give the ranch a call to make a donation at 918-762-2513.”
For more information about the Pawnee Bill Ranch and Museum or directions to the site, please visit www.okhistory.org/pawneebill or call the ranch at 918-762-2513. The Pawnee Bill Ranch and Museum is located at 1141 Pawnee Bill Road in Pawnee.

By Oklahoma Insurance Commissioner Glen Mulready

In Oklahoma, natural disasters are a tragic reality. Every year, disasters disrupt different parts of our state, leaving behind lasting effects on Oklahomans and property. After a disaster, many in our community need help and first responders may not be able to assist right away. That is why it’s important to Get Ready now. You and your family can take simple steps to Get Ready for emergencies and mitigate your risks. Here are some very easy but essential things you can do to Get Ready.
Document Your Property
One of the most important things you can do before a storm hits is to make a home inventory. Keep a detailed record of your valuable belongings to help you recover and file a claim more quickly. Take photos or videos to record your belongings and write down descriptions. Take photos or videos of the inside and outside of your home, including spaces like closets and cabinet interiors. Keep your inventory somewhere away from your home (i.e. safe deposit box, virtual cloud), where it can be accessed after a disaster.
Review Your Insurance
Disasters are a matter of when not if. Understand the risks you may face and talk to your agent to ensure that you have the insurance coverage you need for your property. For example, a standard homeowners policy does not cover floods, and you may need a separate wind and hail policy if you live in tornado-prone areas. It’s also important to prepare your property before the storm hits. Sometimes it is not the storm that directly causes the damage to your home but your possessions that are not secured in your yard. Cut down or trim trees that may be in danger of falling on your home. Secure outdoor objects that could blow away or cause damage.
Make a Plan
Lastly, having a plan in place and knowing how you will respond to the storm can make a significant impact. Be sure to have flashlights, food, water and a weather radio ready at all times. Know how you’ll contact one another and reconnect if separated. Establish a family meeting place that’s familiar and easy to find and practice that plan regularly. Sign up for your community’s alert and warning systems and make sure you understand what these alerts and warnings mean.
To help Oklahomans prepare for this storm season, we’re releasing the three-part column series—Mulready Says Get Ready: Before, During and After the Storm. This comprehensive series will provide you with detailed information on how best to prepare for disasters. In this series, I’ll explain general disaster preparedness tips for before, during and after disasters. Please follow #GetReadyOK and visit www.oid.ok.gov/getready for more information on how to Get Ready.
If you have questions about other insurance issues, please contact the Oklahoma Insurance Department at 1-800-522-0071 or visit our website at www.oid.ok.gov.

On March 22, 2022, at 10 a.m. the Oklahoma Historical Society (OHS) opened the Oklahoma State Capitol Museum, a state-of-the-art gallery space in the Oklahoma State Capitol. Created as part of the Oklahoma Capitol Restoration Project and located on the ground floor near the new primary public entrance on the south side of the Capitol, the Oklahoma State Capitol Museum contains 4,400 square feet of exhibit space and 13 exhibit cases, featuring more than 125 artifacts relating to the history of the Oklahoma State Capitol and the work of Oklahoma’s state government.
“The Oklahoma State Capitol Museum is a necessary addition to our Capitol Building,” said Lt. Gov. Pinnell. “No state can match our heritage and history, and these exhibits will provide Oklahomans and out-of-state visitors with a hands-on way to experience that history. I appreciate the hard work Trait Thompson and the rest of the Oklahoma Historical Society have put in to make this dream a reality.”
“The new Oklahoma State Capitol Museum provides a key educational component to our beautiful Capitol for visitors from around the world,” said Thompson. “The Oklahoma Historical Society has worked very hard to install exhibits that showcase the unique story of our Capitol and help people of all ages understand the important work that takes place within its walls. This museum is an integral part in making the Capitol a must-see destination when people come to Oklahoma City.”
Admission to the Oklahoma State Capitol Museum is free to all visitors. The museum will be open from Monday through Friday from 7 a.m. to 7 p.m., and Saturday and Sunday from 9 a.m. to 4 p.m.

HarborChase of South Oklahoma City

Visit: https://www.tealridge.com/

By Marty Coffin Evans, Columnist

Not long ago, I attended a party celebrating my friend, Diana. Caring Bridge entries likely caused this to happen. She became the hostess rather than our hosting her as we’d planned.
What a great time to celebrate with others who matter in our lives – family, colleagues from different work locations, service club members and more. Her parting gift to us – her Bucket List.
Introducing her list, Diana noted she had done some of the listed things and wished she could do them again. She included activities she never got to do.
What would such a list of 21 items encompass? Hers contained ones pertaining to people (9), places (6) and things (6). The “people” examples included being a grandparent (devoted, joyful, committed), reconnecting with someone not spoken to in a long time, asking for or forgiving someone needing forgiveness, and practicing gratitude every day for family (daughters in her case), friends, relatives and furry friends.
“Place” examples take us on cruises whether with Viking up a river or one through the Greek Islands, touring Ireland, canoeing the Quetico and hearing the loons again along with sitting on a beach and listening to an ocean.
Diana’s “thing” items stretch us a bit as they included volunteering somewhere, taking a class in something new, reading a book outside of what we’d usually select, mastering (not just studying) a second language and picking up/learning a new musical instrument or revisiting one previously played.
Tucked in the middle of her Bucket List: “Take time to notice the light outside, its changes throughout the day, how it modifies the look of trees, grass, sky, clouds, mountains, and how those differences make you feel.”
Diana hoped we’d do one or more from this list in her honor. How wonderful to remember and celebrate another this way!
Martha (Marty) Coffin Evans, Ed.D. is a freelance writer with MACE Associates, LLC. She can be reached at itsmemartee@aol.com.